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Review of the Development of Bi-combined Vaccines Against Viral Diarrhea of Swine

MA Si-qi   

  1. Division of Swine Infectious Diseases, Harbin Veterinary Research Institute of Chinese Academy of Agricultural Sciences, Harbin 150001
  • Online:2007-12-31 Published:2007-12-31

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Abstract: The project consistes of bi-combined killed vaccine against transmissible gastroenteritis virus (TGEV) and porcine epidemic diarrhea virus (PEDV), bi-combined attenuated vaccine against TGEV and PEDV. The protective rate of active immunization of two bi-combined vaccines were 96% and 97.6%, respectively, and the protective rate of passive immunization of two bi-combined vaccines were 84.7% and 98%, respectively. The immunity duration of active immunization lasted 6-7 months, the immunity duration of passive immunization of piglets was from feeding duration to one week post-weaning. The attenuated strains were successfully cultivated by cloning and screening method. A novel immune route was one inoculation at Hou Hai point. After field trial and regional trial, two bi-combined vaccines were widely applied in the country and brought out striking economic benefit, acquired the new veterinary drug certificate of Ministry of Agriculture in 1999 and 2003, respectively. The two bi-combined vaccines were patent products, which had autonomic intellectual property rights. The bi-combined attenuated vaccine gained Second Class Prize of National Science and Technology Award in 2004.

Key words: TGE , PED , Bi-combined vaccine

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