中国猪流行性腹泻病毒分子流行病学研究进展

doi:10.3864/j.issn.0578-1752.2013.20.020

Abstract

Abstract: Porcine epidemic diarrhea (PED) caused heavy economic losses to Chinese pig industry in 2010 and 2011. It was postulated that new variants of porcine epidemic diarrhea virus (PEDV) had played a major role because the vaccine made from previous strains failed to provide efficient protection for infected piglets. This review summarized the investigations on molecular epidemics of PEDV in this period of time in China and made a phylogenetic analysis with published complete genomic sequences. The analysis provided further evidence for the existence a novel genotype PEDV, which was not clustered with Chinese 1986 strains and European CV777 strain. The growing genetic difference between prevailing and vaccine strains should be the cause of vaccination failure as well as high death rate of piglets. Complete genomic sequence analysis showed the length difference of their polymerase (1ab) as well as their spike (S) genes. S gene had the highest mutation rate among the subgenomes, especially within a relatively short period of time. The analysis also implied that the new strains could evolve from domestic strains. Severe PED problem was reported early in 2006, therefore the 2010 to 2012 outbreak of PED could be the result of accumulation of pathogen mutations and adaptation, which also suggested, the importance of evolution surveillance of pathogens by national network.

Key words: porcine epidemic diarrhea , virus , molecular epidemiology

SHI Biao-2, DONG Shi-Juan-1, ZHU Yu-Min-1, YU Rui-Song-1, LI Zhen-1. Advances in Study of Molecular Epidemiology of Porcine Epidemic Diarrhea Virus in China[J].Scientia Agricultura Sinica, 2013, 46(20): 4362-4369.

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