日粮添加维生素E对免疫抑制产蛋鸡经济性状下降的调控效应

doi:10.3864/j.issn.0578-1752.2011.24.014

Abstract

Abstract: 【Objective】The modulation of dietary vitamin E levels on immunosuppressed laying hens induced by cyclophosphamide (CTX) was studied. 【Method】Two hundred and seventy Nick Red laying hens were randomly divided into 5 groups and each group had 3 replications with 18 birds. Laying hens from group Ⅲ, Ⅳ, and Ⅴ(birds treated with vitamin E) were fed diets supplemented with 50, 100 and 200 mg•kg-1 vitamin E, respectively, whereas group Ⅰ and Ⅱ received only the corn-soybean meal basal diets with 44.59 mg•kg-1 of vitamin E. Laying hens in group Ⅱ-Ⅳ(birds challenged with CTX) were injected in the thigh muscle with CTX at 80 body weight for 3 days, and that in groupⅠ(control group) were injected with the same amount of sterile saline. 【Result】Supplemental vitamin E significantly increased egg production, feed efficiency and nutrient digestibility (P＜0.05). The relative weights of the spleen and thymus to the body weight, serum HI antibody titers to H5-AI, H9-AI and ND, plasma GSH-Px and SOD activities were greater in immunosuppressed birds fed supplemented vitamin E (P＜0.05), and the MDA concentration was least at 50 mg•kg-1 supplemental vitamin E, and further additions had negative effect (P＜0.05). Birds treated with CTX fed diets with supplemental 100 and 200 mg vitamin E/kg had greater plasma PGE2, IL-1, IL-6, and TNF-α levels (P＜0.05). 【Conclusion】The results showed that dietary vitamin E supplementation significantly attenuated immunosuppressive effect of CTX challenge in laying hens.

Key words: vitamin E, laying hens, immunosuppression, mechanism

PENG Bing-Yong, GAO Yu-Peng, WANG Chun-Jiang, ZHENG Hai-Zu, HUANG Fu-Yi-Fan, JI Jian-Xin. Modulation of Dietry Vitamin E on Economic Characterization of Immunosupressed Laying Hens[J].Scientia Agricultura Sinica, 2011, 44(24): 5083-5091.

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