Scientia Agricultura Sinica ›› 2008, Vol. 41 ›› Issue (1): 182-187 .doi: 10.3864/j.issn.0578-1752.2008.01.024

• STORAGE·FRESH-KEEPING·PROCESSING • Previous Articles     Next Articles

Effect of Pollen Polysaccharide on Production and mRNA Expression of IL-2 and TNF-α in Spleen Cells of Mice with Tumor-bearing

  

  1. 华中农业大学园艺林学学院/园艺植物生物学教育部重点实验室
  • Received:2006-05-10 Revised:1900-01-01 Online:2008-01-10 Published:2008-01-10

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Abstract: 【Objective】The effects of LBPP (polysaccharide of pollen of Brassica napus L.)on the production and mRNA expression of IL-2 and TNF-α in spleen cells of mice with tumor-bearing were investigated.【Method】Through transplantable animal tumor, two-antibody-sandwich ELISA was used to detect the activity of IL-2 and TNF-α, and RT-PCR (revrse transcription-polymerase chain reaction) was used to detect the mRNA expression of IL-2 and TNF-α.【Result】LBPP could significantly inhibit the growth of tumor, and significantly improve the production of IL-2 and TNF-α and its mRNA expression (p<0.01).【Conclusion】The anti-tumor activity of LBPP was due to enhance IL-2 and TNF-α mRNA expression.

Key words: Pollen, Polysaccharide, IL-2, TNF-α, mRNA

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