Scientia Agricultura Sinica ›› 2010, Vol. 43 ›› Issue (9): 1919-1925 .doi: 10.3864/j.issn.0578-1752.2010.09.019

• STORAGE·FRESH-KEEPING·PROCESSING • Previous Articles     Next Articles

Effects of Water Soluble Extracts from Longan on Immune Regulation in Normal Mice

SU Dong-xiao, ZHANG Ming-wei, LIAO Sen-tai, HOU Fang-li, ZHANG Rui-fen, TANG Xiao-jun, WEI Zhen-cheng, ZHANG Yan, CHI Jian-wei, DENG Yuan-yuan
  

  1. (广东省农业科学院农业生物技术研究所/农业部功能食品重点开放实验室)
  • Received:2009-09-17 Revised:2010-01-31 Online:2010-05-01 Published:2010-05-01
  • Contact: ZHANG Ming-wei

Abstract:

【Objective】 The objective of this experiment is to study the effects of water soluble extracts from longan on immune regulation in normal mice. 【Method】 One hundred and twenty mice were randomly divided into five groups: the normal control group, low dose longan extracts (130 mg•d-1), high dose longan extracts (380 mg•d-1), low dose longan slurry (150 mg•d-1), and high dose longan slurry (450 mg•d-1). After mice were orally administered for 35 days, changes on weight, index of immune organs, indexes of spleen lymphocyte transformation, hemolysin value of blood serum, NK cell activity, plaque-forming cell response were assayed by dissolving CRBC. Besides, four anti- oxidation indicators serum malondialdehyde level, total antioxidant capacity, glutathione peroxidase and superoxide dismutase activity were also investigated. 【Result】 Compared to normal control group, both doses of longan extracts greatly improved hemolysin value of blood serum and indexes of spleen lymphocyte transformation(P<0.05) ,but the results showed no significant effect in the cases of longan slurry groups (P>0.05). And high dose longan extracts enhanced NK cell activity signifcantly (P<0.05), yet both doses of longan slurry groups showed on significant effects (P>0.05). High dose longan slurry reduced the MDA of blood serum (P<0.05), yet the longan extract groups did not show significant effects (P>0.05). T-AOC was increased by high dose longan slurry (P<0.01) and high dose longan extracts (P<0.05), respectively. 【Conclusion】It is concluded that longan extracts have a promoting effect on immune functions and antioxidation activity of normal mice, yet the anti- oxidation activity of longan is not the main mechanism for immune regulation actions.

Key words: longan, water soluble extracts, normal mice, immune regulation, anti-oxidation

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