围产期日粮添加姜黄素对山羊生产性能、血液指标及炎症因子基因表达的影响

doi:10.3864/j.issn.0578-1752.2024.12.016

Abstract

Abstract:

【Background】 The reproductive capacity of goat has a direct impact on the mutton sheep industry, and the perinatal period is a special physiological period in the goat breeding process. During this stage, the feed intake and energy intake decreases, and the nutritional needs of the offspring increase sharply. Goats are prone to enter a state of negative energy balance, which can induce a series of adverse reactions, such as metabolic diseases, inflammatory reactions, immune suppression, and even miscarriage.【Objective】 This study aimed to investigate the alleviation role of curcumin in the perinatal diet on negative energy balance state of goats, by evaluating goat production performance, blood indicators and inflammatory factor gene expression, to improve the health of perinatal goats. 【Method】 Eighteen Subai goats with 122 days of gestation (i.e. 28 days before delivery) were divided into Con group (no supplement) and Cur group (supplemented with curcumin 800 mg·kg^-1 DMI). Blood sample was collected on 21 days (d-₂₁) before delivery and 0 (d₀) and 21 days (d₂₁) after delivery. Goat production performance, blood indicators and inflammatory factor gene expression were measured. 【Result】 Cur treatment did not affect goat feed intake, birth weight or daily gain of lambs. The goat feed intake of both groups before and after delivery tended to decrease and then increase, with the lowest feed intake on the day of delivery (P=0.097). Cur treatment tended to increase serum Glu concentration (P=0.075). Cur treatment significantly reduced serum NEFA content on d₀ and d₂₁ (P<0.05), but did not affect serum low-density lipoprotein, high-density lipoprotein, total cholesterol, or triglyceride content (P>0.05). Cur treatment tended to increase serum total T-AOC level on d₂₁ (P=0.073), and significantly reduced serum MDA content on d₀, but did not affect serum SOD or GSH-Px level (P>0.05). Cur treatment did not affect serum IgA, IgG or IgM content (P>0.05). Cur treatment significantly increased the expression of Nrf2 in whole blood on d₂₁ (P<0.05) and decreased the expression of TNFα on d₀ (P<0.05), but did not affect the gene expression of IL-1, IL-6 and IFNγ (P>0.05). 【Conclusion】 Adding curcumin to peripartum diets could reduce serum NEFA level, enhance antioxidant properties, and reduce inflammatory responses to a certain extent in goats.

Key words: periparturient goat, production performance, lipid metabolism, immunity, inflammatory, anti-oxidation

CHEN HengGuang, PEI XiaoMeng, XIA YuTing, LIU Jing, MAO DaGan. Effects of Adding Curcumin to Perinatal Diets on Production Performance, Blood Indexes and Gene Expression of Inflammatory Factors in Goats[J].Scientia Agricultura Sinica, 2024, 57(12): 2483-2496.

0
/ / Recommend

Add to citation manager EndNote|Reference Manager|ProCite|BibTeX|RefWorks

URL: https://www.chinaagrisci.com/EN/10.3864/j.issn.0578-1752.2024.12.016

https://www.chinaagrisci.com/EN/Y2024/V57/I12/2483

Figures/Tables 9

Table 1

Table 2

Table 3

Table 4

Table 5

Fig. 1

Fig. 2

Fig. 3

Fig. 4

References 67

[1]	ABDELLATIF M A, ELGOHARY E, AA G, ELHAWARY A F, SA A, EBRAHIM S A, FATHALA M. Impact of supplementing propylene glycol and calcium propionate to primiparous buffalo cows during the late gestation and early lactation period on reproductive performance and metabolic parameters. Alexandria Journal of Veterinary Sciences, 2016, 51(1): 114.
[2]	TAYLOR V J, BEEVER D E, WATHES D C. Physiological adaptations to milk production that affect the fertility of high yielding dairy cows. BSAP Occasional Publication, 2004, 29: 37-71.
[3]	BERNABUCCI U, RONCHI B, LACETERA N, NARDONE A. Influence of body condition score on relationships between metabolic status and oxidative stress in periparturient dairy cows. Journal of Dairy Science, 2005, 88(6): 2017-2026. doi: 10.3168/jds.S0022-0302(05)72878-2 pmid: 15905432
[4]	赵春蕊. 规模化奶山羊养殖场分娩过渡期、围产期和哺乳期管理技术试验示范与应用[D]. 杨凌: 西北农林科技大学, 2022.
	ZHAO C R. Experimental demonstration and application of delivery transition period, perinatal period and lactation period management technology in large-scale dairy goat farm[D]. Yangling: Northwest A & F University, 2022. (in Chinese)
[5]	孙菲菲, 曹阳春, 李生祥, 韩金涛, 姚军虎. 胆碱对奶牛围产期代谢的调控. 动物营养学报, 2014, 26(1): 26-33. doi: 10.3969/j.issn.1006-267x.2014.01.004
	SUN F F, CAO Y C, LI S X, HAN J T, YAO J H. Regulation of choline on nutrient metabolism in periparturient dairy cows: a review. Chinese Journal of Animal Nutrition, 2014, 26(1): 26-33. (in Chinese)
[6]	魏筱诗. 烟酰胺对围产期奶畜糖脂代谢及其子代肠道发育的影响和机制[D]. 杨凌: 西北农林科技大学, 2019.
	WEI X S. Nicotinamide regulates glucose and lipid metabolism of transition dairy andintestinal development of offspring: effects and potential mechanisms[D]. Yangling: Northwest A & F University, 2019. (in Chinese)
[7]	田超. 围产期奶牛亚临床酮病的临床特征及甘草酸单铵盐的预防效果[D]. 扬州: 扬州大学, 2021.
	TIAN C. Clinical features of subclinical ketosis in perinatal dairy cows and the preventive effect of monoammonium glycyrrhizinate[D]. Yangzhou: Yangzhou University, 2021. (in Chinese)
[8]	张昕乐, 王智博, 陈培勇, 王远孝, 张艳丽, 王锋, 尤佩华, 樊懿萱. 围产期湖羊能量负平衡下添加三丁酸甘油酯对羔羊瘤胃发酵指标及微生物多样性的影响. 南京农业大学学报, 2023, 46(5): 933-938.
	ZHANG X L, WANG Z B, CHEN P Y, WANG Y X, ZHANG Y L, WANG F, YOU P H, FAN Y X. Effects of tributyrin supplementation on rumen fermentation indexes and microbial diversity of lambs under negative energy balance in perinatal Hu sheep. Journal of Nanjing Agricultural University, 2023, 46(5): 933-938. (in Chinese)
[9]	熊程坤. 芦丁对围产期湖羊瘤胃代谢、微生物区系和抗氧化性能的影响[D]. 合肥: 安徽农业大学, 2023.
	XIONG C K. Effects of rutin on rumen metabolism, microflora and antioxidant properties of perinatal Hu sheep[D]. Hefei: Anhui Agricultural University, 2023. (in Chinese)
[10]	张赛伟. 甘露寡糖对围产期湖羊养分消化、血清指标、瘤胃发酵及微生物区系的影响[D]. 保定: 河北农业大学, 2023.
	ZHANG S W. Effects of mannan oligosaccharides on nutrient digestion, serum biochemical indicators, rumen fermentation and microflora in perinatal period of Hu sheep[D]. Baoding: Hebei Agricultural University, 2023. (in Chinese)
[11]	MAHDAVI H, HADADI Z, AHMADI M. A review of the anti-oxidation, anti-inflammatory and anti-tumor properties of curcumin. Traditional and Integrative Medicine, 2017: 188-195.
[12]	MONIRUZZAMAN M, MIN T. Curcumin, curcumin nanoparticles and curcumin nanospheres: a review on their pharmacodynamics based on monogastric farm animal, poultry and fish nutrition. Pharmaceutics, 2020, 12(5): 447.
[13]	XIE Z L, SHEN G Z, WANG Y, WU C B. Curcumin supplementation regulates lipid metabolism in broiler chickens. Poultry Science, 2019, 98(1): 422-429. doi: 10.3382/ps/pey315 pmid: 30053224
[14]	田久林. 围产期补饲海带水解物对荷斯坦奶牛泌乳性能和血液指标的影响[D]. 泰安: 山东农业大学, 2023.
	TIAN J L. Effects of periparturient supplementation with Laminaria japonica hydrolysate on lactation performance and blood parameters in Holstein cows[D]. Taian: Shandong Agricultural University, 2023. (in Chinese)
[15]	王一臻. 地顶孢霉培养物对奶牛瘤胃发酵及围产期奶牛的影响[D]. 哈尔滨: 东北农业大学, 2017.
	WANG Y Z. Effects of Acremonium terricola culture on ruminal fermentation and transition dairy cows[D]. Harbin:Northeast Agricultural University, 2017. (in Chinese)
[16]	李涛. 植物源饲料对鸡生产性能、抗氧化能力及槲皮素对卵泡发育的影响研究[D]. 镇江: 江苏科技大学, 2022.
	LI T. Study on the effect of the phytogenic feed additives on chicken reproduction performance, antioxidant capacity and functional role of quercetin on follicle development[D]. Zhenjiang: Jiangsu University of Science and Technology, 2022. (in Chinese)
[17]	ILSLEY S E, MILLER H M, KAMEL C. Effects of dietary quillaja saponin and curcumin on the performance and immune status of weaned piglets. Journal of Animal Science, 2005, 83(1): 82-88. pmid: 15583046
[18]	ASARIAN L, GEARY N. Modulation of appetite by gonadal steroid hormones. Philosophical Transactions of the Royal Society of London Series B, Biological Sciences, 2006, 361(1471): 1251-1263.
[19]	毛鑫智. 分娩前后母绵羊及其胎儿的血液组成以及母羊采食量的变化. 中国应用生理学杂志, 1987, 3(2): 156-160.
	MAO X Z. Changes of blood compositions in ewes and their fetuses and food intake of ewes during 10 days before and after parturition. Chinese Journal of Applied Physiology, 1987, 3(2): 156-160. (in Chinese)
[20]	BERTICS S J, GRUMMER R R, CADORNIGA-VALINO C, STODDARD E E. Effect of prepartum dry matter intake on liver triglyceride concentration and early lactation. Journal of Dairy Science, 1992, 75(7): 1914-1922. pmid: 1500587
[21]	WU Z L, HOU Y Q, HU S D, BAZER F W, MEININGER C J, MCNEAL C J, WU G Y. Catabolism and safety of supplemental l-arginine in animals. Amino Acids, 2016, 48(7): 1541-1552. doi: 10.1007/s00726-016-2245-9 pmid: 27156062
[22]	GLUCKMAN P D, CUTFIELD W, HOFMAN P, HANSON M A. The fetal, neonatal, and infant environments-the long-term consequences for disease risk. Early Human Development, 2005, 81(1): 51-59. pmid: 15707715
[23]	VAN EMON M L, SCHAUER C S, ECKERMAN S R, MADDOCK CARLIN K R, VONNAHME K A. Supplementing metabolizable protein to ewes during late gestation: II. Effects on ewe lamb performance and reproductive efficiency. Journal of Animal Science, 2015, 93(3): 1332-1339. doi: 10.2527/jas.2014-7609 pmid: 26020910
[24]	高峰, 侯先志. 妊娠后期不同营养水平对蒙古绵羊胎儿生长发育的影响. 中国农业科学, 2007, 40(6): 1260-1264.
	GAO F, HOU X Z. Effect of maternal undernutrition during late pregnancy on ovine fetal growth and development. Scientia Agricultura Sinica, 2007, 40(6): 1260-1264. (in Chinese)
[25]	张春艳. 山羊繁殖性状的影响因素和遗传规律及分子调控机制研究[D]. 武汉: 华中农业大学, 2010.
	ZHANG C Y. The factors and hereditary rule as well as molecular regulation mechanism of fertility traits in the goat[D]. Wuhan: Huazhong Agricultural University, 2010. (in Chinese)
[26]	张剑搏, 袁超, 岳耀敬, 郭健, 牛春娥, 王喜军, 王丽娟, 吕会芹, 杨博辉. 不同动物模型对高山美利奴羊早期生长性状遗传参数估计的比较. 中国农业科学, 2018, 51(6): 1202-1212. doi: 10.3864/j.issn.0578-1752.2018.06.018.
	ZHANG J B, YUAN C, YUE Y J, GUO J, NIU C E, WANG X J, WANG L J, LÜ H Q, YANG B H. Comparison and analysis of genetic parameters estimation of early growth traits of alpine merino sheep by different animal models. Scientia Agricultura Sinica, 2018, 51(6): 1202-1212. doi: 10.3864/j.issn.0578-1752.2018.06.018. (in Chinese)
[27]	GARDNER D S, BUTTERY P J, DANIEL Z, SYMONDS M E. Factors affecting birth weight in sheep: maternal environment. Reproduction, 2007, 133(1): 297-307.
[28]	BYRAM K W, OESER A M, LINTON M F, FAZIO S, STEIN C M, ORMSETH M J. Exercise is associated with increased small HDL particle concentration and decreased vascular stiffness in rheumatoid arthritis. Journal of Clinical Rheumatology: Practical Reports on Rheumatic & Musculoskeletal Diseases, 2018, 24(8): 417-421.
[29]	左之才. 不同能量水平对围产期奶牛生产性能、血液生化及内分泌因子影响的研究[D]. 雅安: 四川农业大学, 2004.
	ZUO Z C. Peripartum performance, blood-biochemistry index and endocrine factors of dairy cows in response to prepartum energy intake[D]. Yaan: Sichuan Agricultural University, 2004. (in Chinese)
[30]	JIANG Z Y, WAN Y J, LI P, XUE Y, CUI W W, CHEN Q, CHEN J Q, WANG F, MAO D G. Effect of curcumin supplement in summer diet on blood metabolites, antioxidant status, immune response, and testicular gene expression in hu sheep. Animals: an Open Access Journal from MDPI, 2019, 9(10): 720.
[31]	骆伟. 过瘤胃营养添加剂对围产期及泌乳早期奶牛生产性能和血液生化指标的影响研究[D]. 合肥: 安徽农业大学, 2010.
	LUO W. Study on effect of rumen bypass-nutritional additive on performance and plasma metabolites of dairy cows in peripartum and early lactation period[D]. Hefei: Anhui Agricultural University, 2010. (in Chinese)
[32]	熊桂林, 付志新, 曹随忠, 顾建红, 陈大伟, 刘宗平. 奶牛围产期血清脂肪代谢、肝脏功能和氧化指标的变化. 畜牧兽医学报, 2010, 41(8): 1039-1045.
	XIONG G L, FU Z X, CAO S Z, GU J H, CHEN D W, LIU Z P. Changes in serum fat metabolism, liver function and lipid peroxidation of the transition cow. Chinese Journal of Animal and Veterinary Sciences, 2010, 41(8): 1039-1045. (in Chinese)
[33]	王家晶. 奶牛围产期血清脂肪代谢及肝脏功能相关指标变化的研究[D]. 扬州: 扬州大学, 2014.
	WANG J J. Study on the changes of serum lipid metabolism and liver function related indicators in peripartum dairy cow[D]. Yangzhou: Yangzhou University, 2014. (in Chinese)
[34]	Committee on Technological Options to Improve the Nutritional Attributes of Animal Products. Designing foods: animal product options in the marketplace. Washington, D.C.: National Academy Press, 1988.
[35]	张萌, 刘国林, 李向龙, 陈永宏, 白玲荣, 罗芳, 李亚超, 陶金忠. 运动对围产期奶牛血液生化指标及免疫指标的影响. 中国兽医学报, 2020, 40(1): 153-161.
	ZHANG M, LIU G L, LI X L, CHEN Y H, BAI L R, LUO F, LI Y C, TAO J Z. Effects of exercise on blood biochemical indexes and immune indexes of dairy cows during perinatal period. Chinese Journal of Veterinary Science, 2020, 40(1): 153-161. (in Chinese)
[36]	KEHLENBRINK S, KOPPAKA S, MARTIN M, RELWANI R, CUI M H, HWANG J H, LI Y, BASU R, HAWKINS M, KISHORE P. Elevated NEFA levels impair glucose effectiveness by increasing net hepatic glycogenolysis. Diabetologia, 2012, 55(11): 3021-3028. doi: 10.1007/s00125-012-2662-6 pmid: 22847060
[37]	周明, 张靖, 申书婷, 王欢, 李泽阳, 陈征义. 姜黄素在育肥猪中应用效果的研究. 中国粮油学报, 2014, 29(3): 67-73.
	ZHOU M, ZHANG J, SHEN S T, WANG H, LI Z Y, CHEN Z Y. The applied effects of curcumin in finishing swine. Journal of the Chinese Cereals and Oils Association, 2014, 29(3): 67-73. (in Chinese)
[38]	桑丹, 娜美日嘎, 孙海洲, 金鹿, 张崇志, 张春华, 王双锁, 刘拥军, 敖长金. 5-羟色胺前体物对围产期母羊泌乳性能及血浆生化指标的影响. 动物营养学报, 2019, 31(12): 5601-5612. doi: 10.3969/j.issn.1006-267x.2019.12.026
	SANGDAN, NAMEIRIGA, SUN H Z, JIN L, ZHANG C Z, ZHANG C H, WANG S S, LIU Y J, AO C J. Effects of 5-hydroxytryptamine precursor on lactation performance and plasma biochemical indexes of perinatal ewes. Chinese Journal of Animal Nutrition, 2019, 31(12): 5601-5612. (in Chinese)
[39]	关文怡, 乔立东, 张凡建. 围产期奶牛血清代谢物和相关激素水平的变化规律研究. 中国畜牧杂志, 2019, 55(6): 128-130.
	GUAN W Y, QIAO L D, ZHANG F J. Study on changes of serum metabolites and related hormones in dairy cows during transition period. Chinese Journal of Animal Science, 2019, 55(6): 128-130. (in Chinese)
[40]	CELI P. Biomarkers of oxidative stress in ruminant medicine. Immunopharmacology and Immunotoxicology, 2011, 33(2): 233-240.
[41]	TIAN G Y, ZHANG X Z, HAO X Y, ZHANG J X. Effects of curcumin on growth performance, ruminal fermentation, rumen microbial protein synthesis, and serum antioxidant capacity in housed growing lambs. Animals: an Open Access Journal from MDPI, 2023, 13(9): 1439.
[42]	ODERINWALE O A, OLUWATOSIN B O, ONAGBESAN M O, ADEKUNLE E O, SHUAIBU A Y, AMOSU S D, ADEYEMO A J, KUYE O M, OLALERE J O, AJEWOLE I T. Effects of dietary inclusion of turmeric (Curcuma longa L.) powder on oxidative stress and cortisol concentration in goats during pregnancy and onset of postpartum. Nigerian Journal of Animal Production, 2022, 48(6): 374-390.
[43]	张春刚, 苏效双, 刘光磊, 吴天佑, 占今舜, 赵国琦. 复方中草药添加剂对荷斯坦奶牛免疫和泌乳性能的影响. 草业学报, 2017, 26(11): 104-112. doi: 10.11686/cyxb2017050
	ZHANG C G, SU X S, LIU G L, WU T Y, ZHAN J S, ZHAO G Q. Effects of feeding compound herbal additives on immunity status and lactation performance in Holstein cows. Acta Prataculturae Sinica, 2017, 26(11): 104-112. (in Chinese)
[44]	熊桂林. 硫辛酸对围产期奶牛的抗氧化作用研究[D]. 扬州: 扬州大学, 2009.
	XIONG G L. Studies on antioxidation of α-lipoic acid in the transition cow[D]. Yangzhou: Yangzhou University, 2009. (in Chinese)
[45]	GLOMBOWSKY P, VOLPATO A, CAMPIGOTTO G, SOLDÁ N M, DA S DOS SANTO D, BOTTARI N B, SCHETINGER M R C, MORSCH V M, RIGON F, SCHOGOR A L B, DA SILVA A S. Dietary addition of curcumin favors weight gain and has antioxidant, antiinflammatory and anticoccidial action in dairy calves. Revista Colombiana De Ciencias Pecuarias, 2020, 33(1): 16-31.
[46]	邓卉, 杨加豹, 陈瑾, 朱淋, 邹成义. 姜黄素对川藏黑仔猪生长性能、机体抗氧化及免疫功能的影响. 中国饲料, 2018(12): 31-35.
	DENG H, YANG J B, CHEN J, ZHU L, ZOU C Y. Effects of curcumin on growth performance, antioxidant and immunology function of Chuanzang black piglets. China Feed, 2018(12): 31-35. (in Chinese)
[47]	赵洁, 陈恒光, 裴晓蒙, 于昊, 徐银莹, 茆达干. 围产期日粮添加白藜芦醇对山羊生产性能、血液指标及炎症因子基因表达的影响. 草业学报, 2024: 1-11.
	ZHAO J, CHEN H G, PEI X M, YU H, XU Y Y, MAO D G. Effects of resveratrol supplementation in the perinatal diet on production performance, blood indexes, and transcript abundance of genes encoding inflammatory factors in goats. Acta Prataculturae Sinica, 2024: 1-11. (in Chinese)
[48]	HALLIWELL B, CHIRICO S. Lipid peroxidation: its mechanism, measurement, and significance. The American Journal of Clinical Nutrition, 1993, 57(5 Suppl.): 715S-725S.
[49]	孙菲菲. 胆碱和蛋氨酸对奶牛围产期营养平衡和机体健康的影响及机制[D]. 杨凌: 西北农林科技大学, 2017.
	SUN F F. Choline and methionine regulate nutrient balance and health of transition dairy cows: responses and potential mechanisms[D]. Yangling: Northwest A & F University, 2017. (in Chinese)
[50]	仇凡. 姜黄素对绵羊生产性能、奶品质和健康的影响. 中国饲料, 2019(14): 71-75.
	QIU F. Effects of curcumin on performance, milk quality and health of sheep. China Feed, 2019(14): 71-75. (in Chinese)
[51]	王金飞, 杨国义, 樊子菡, 刘旗, 张鹏程, 任有蛇, 杨春合, 张春香. 饲粮中全株玉米青贮比例对杜湖杂交母羔生长性能、瘤胃发酵、养分消化率及血清学指标的影响. 中国农业科学, 2021, 54(4): 831-844. doi: 10.3864/j.issn.0578-1752.2021.04.014.
	WANG J F, YANG G Y, FAN Z H, LIU Q, ZHANG P C, REN Y S, YANG C H, ZHANG C X. Effects of whole plant corn silage ratio in diet on growth performance, rumen fermentation, nutrient digestibility and serological parameters of Dorper × Hu crossbred female lambs. Scientia Agricultura Sinica, 2021, 54(4): 831-844. doi: 10.3864/j.issn.0578-1752.2021.04.014. (in Chinese)
[52]	JOHNSON B A, HOFFMANN L G. Effect of reduction and alkylation on structure and function of rabbit IgG antibody-I. Effect on ability to activate complement depends on conditions of reduction. Molecular Immunology, 1981, 18(3): 181-188. pmid: 7266486
[53]	刘国林, 陶金忠, 白玲荣, 李向龙, 陈永宏, 张萌, 罗芳, 李亚超, 郭延生. 山楂和黄芪对围产期奶牛血液生化指标和免疫指标的影响. 河南农业科学, 2020, 49(2): 150-158.
	LIU G L, TAO J Z, BAI L R, LI X L, CHEN Y H, ZHANG M, LUO F, LI Y C, GUO Y S. Effects of hawthorn and Astragalus on blood biochemical and immunological indexes of dairy cows during perinatal period. Journal of Henan Agricultural Sciences, 2020, 49(2): 150-158. (in Chinese)
[54]	李刚诗, 王晓艳, 袁听, 周紫峣, 唐天亮, 石先鹏, 谷武阳, 解冰冰, 王方园, 李魏, 刘长松, 彭广能, 钟志军. 围产期健康奶牛血清和初乳中免疫球蛋白含量的变化. 中国兽医学报, 2015, 35(2): 273-277.
	LI G S, WANG X Y, YUAN T, ZHOU Z Y, TANG T L, SHI X P, GU W Y, XIE B B, WANG F Y, LI W, LIU C S, PENG G N, ZHONG Z J. Changes of immunoglobulin protein content in serum and colostrum during healthy periparturient dairy cows. Chinese Journal of Veterinary Science, 2015, 35(2): 273-277. (in Chinese)
[55]	范春玲, 兰明慧, 周玉龙, 张旭, 李淑静, 王恒根, 孙斌. 酵母铬对围产后期奶牛免疫功能和泌乳性能的影响. 中国畜牧杂志, 2013, 49(23): 36-40.
	FAN C L, LAN M H, ZHOU Y L, ZHANG X, LI S J, WANG H G, SUN B. Effects of dietary Cr-yeast supplementation on immune function and milk performance in postpartum dairy cows. Chinese Journal of Animal Science, 2013, 49(23): 36-40. (in Chinese)
[56]	王建东, 马吉锋, 侯鹏霞, 于洋, 梁小军. 枸杞多糖对围产期奶牛抗体水平和细胞因子分泌的影响. 动物医学进展, 2018, 39(4): 68-71.
	WANG J D, MA J F, HOU P X, YU Y, LIANG X J. The study of effect of Lycium barbarum polysaccharide immune synergist on immunity of dairy cows. Progress in Veterinary Medicine, 2018, 39(4): 68-71. (in Chinese)
[57]	BOURNE F J, CURTIS J. The transfer of immunoglobins IgG, IgA and IgM from serum to colostrum and milk in the sow. Immunology, 1973, 24(1): 157-162. pmid: 4685370
[58]	SORDILLO L M, RAPHAEL W. Significance of metabolic stress, lipid mobilization, and inflammation on transition cow disorders. The Veterinary Clinics of North America Food Animal Practice, 2013, 29(2): 267-278.
[59]	CHEN L L, DENG H D, CUI H M, FANG J, ZUO Z C, DENG J L, LI Y L, WANG X, ZHAO L. Inflammatory responses and inflammation-associated diseases in organs. Oncotarget, 2018, 9(6): 7204-7218. doi: 10.18632/oncotarget.23208 pmid: 29467962
[60]	JANG D I, LEE A H, SHIN H Y, SONG H R, PARK J H, KANG T B, LEE S R, YANG S H. The role of tumor necrosis factor alpha (TNF-α) in autoimmune disease and current TNF-α inhibitors in therapeutics. International Journal of Molecular Sciences, 2021, 22(5): 2719.
[61]	刘鹏. 围产期血清中炎性细胞因子变化规律及产后泌乳性能的关联研究[D]. 泰安: 山东农业大学, 2017.
	LIU P. Association of inflammatory cytokines in perinatal serum and postpartum lactation performance[D]. Taian: Shandong Agricultural University, 2017. (in Chinese)
[62]	SINGH U, BARIK A, SINGH B G, PRIYADARSINI K I. Reactions of reactive oxygen species (ROS) with curcumin analogues: structure- activity relationship. Free Radical Research, 2011, 45(3): 317-325.
[63]	LIU M, ZHOU X, WANG X J, WANG Y S, YANG S J, DING Z M, ZHANG S X, ZHANG L D, DUAN Z Q, LIANG A X, HUO L J. Curcumin alleviates bisphenol AF-induced oxidative stress and apoptosis in caprine endometrial epithelial cells via the Nrf2 signaling pathway. Environmental Toxicology, 2023, 38(12): 2904-2914. doi: 10.1002/tox.23925 pmid: 37555465
[64]	荀文娟, 周汉林, 侯冠彧, 曹婷, 施力光, 赵春萍. 姜黄素对早期断奶仔猪回肠黏膜形态、紧密连接蛋白和炎性因子基因表达以及血清免疫球蛋白水平的影响. 动物营养学报, 2016, 28(3): 826-833.
	XUN W J, ZHOU H L, HOU G Y, CAO T, SHI L G, ZHAO C P. Effects of curcumin on ileum mucosal morphology, gene expression of tight junction proteins and inflammatory cytokines, and serum immunoglobulin levels of early weaning piglets. Chinese Journal of Animal Nutrition, 2016, 28(3): 826-833. (in Chinese)
[65]	ZHANG L G, ZHANG J Q, YAN E F, HE J T, ZHONG X, ZHANG L L, WANG C, WANG T. Dietary supplemented curcumin improves meat quality and antioxidant status of intrauterine growth retardation growing pigs via Nrf2 signal pathway. Animals: an Open Access Journal from MDPI, 2020, 10(3): 539.
[66]	李慧, 杨林. Nrf2抗氧化的分子调控机制. 生物信息学, 2018, 16(1): 1-6.
	LI H, YANG L. Molecular regulatory mechanism of Nrf2 antioxidant. Chinese Journal of Bioinformatics, 2018, 16(1): 1-6. (in Chinese)
[67]	KOBAYASHI E H, SUZUKI T, FUNAYAMA R, NAGASHIMA T, HAYASHI M, SEKINE H, TANAKA N, MORIGUCHI T, MOTOHASHI H, NAKAYAMA K, YAMAMOTO M. Nrf2 suppresses macrophage inflammatory response by blocking proinflammatory cytokine transcription. Nature Communications, 2016, 7: 11624. doi: 10.1038/ncomms11624 pmid: 27211851

Metrics

Viewed

Full text

Abstract

Cited

Shared

Discussed

Comments

Recommended 0

No Suggested Reading articles found!

原料组成 Diet ingredient (%)	产前日粮 Prepartum diet	产后日粮 Postpartum diet	营养水平 Nutrition level	产前日粮 Prepartum diet	产后日粮 Postpartum diet
玉米 Corn grain	27.78	30.50	消化能DE (MJ·kg^-1)	14.17	14.66
麸皮 Wheat bran	16.67	5.00	粗蛋白 CP (%)	14.89	17.69
豆粕 Soybean meal	5.56	10.0	酸性洗涤纤维 ADF (%)	24.22	21.93
预混料 Premix	2.78	2.50	中性洗涤纤维 NDF (%)	31.03	36.25
食盐 NaCl	0.56	0.25	粗脂肪 EE (%)	3.79	3.88
蒙脱石 Montmorillonite	0.11	0.50	粗灰分 Ash (%)	4.84	5.26
鱼肝油 Cod liver oil	0.28	0.13	钙 Ca (%)	0.50	0.65
磷酸氢钙 CaHPO₄	0.44	0.50	磷 P (%)	0.38	0.39
小苏打 NaHCO₃	1.11	0.50
维生素E VE	0.28	0.13
玉米青贮 Silage corn	35.56	40.00
花生秧 Peanut grass	8.89	10.00
合计 Total	100	100

基因 Gene	序列号 Genbank number	引物序列 Sequence of nucleotide (5’-3’)		产物长度 Product length (bp)
IL-1β	XM_013967700.2	F	AATGAGCCGAGAAGTGGTGTT	80
IL-1β	XM_013967700.2	R	TACCCAAGGCCACAGGAATCT	80
TNFα	NM_001286442.1	F	CTGGTTCAGACACTCAGGTCA	120
TNFα	NM_001286442.1	R	GAGGGCATTGGCATACGAG	120
HO-1	NM_001285567.1	F	AGCAAGGCACAAGACTCGG	142
HO-1	NM_001285567.1	R	ACATTGCGTAAAGGCCCACA	142
IFNγ	NM_001285682.1	F	GCAGATCCAGCGCAAAGCCAT	119
IFNγ	NM_001285682.1	R	TTGATGCTCTCCGGCCTCGAA	119
IL-6	NM_001285640.1	F	CAGCAAGGAGACACTGGCAGAA	95
IL-6	NM_001285640.1	R	AGCAAATCGCCTGATTGAACCC	95
Nrf2	NM_001314327.1	F	TGACAATGAGGTTTCTTCG	129
Nrf2	NM_001314327.1	R	GTGGCTACCTGAACGAACA	129
GAPDH	XM-005680968.3	F	CCGTTCGACAGATAGCCGTAA	296
GAPDH	XM-005680968.3	R	AGGATCTCGCTCCTGGAAGAT	296

	d_-21	d ₀	d ₂₁	P
	d_-21	d ₀	d ₂₁	组别 Group	时间 Time	组别×时间 Group ×Time
对照组Con	1.49±0.13	1.44±0.14	1.51±0.11	0.523	0.097	0.694
姜黄素组Cur	1.50±0.13	1.41±0.10	1.53±0.07	0.523	0.097	0.694

项目 Item	对照组 Con	姜黄素组 Cur	P
项目 Item	对照组 Con	姜黄素组 Cur	组别Group	协方差<BOLD>C</BOLD>ovariate
初生重 Birth weight (kg)	2.86±0.61	2.76±0.62	0.24	0.006
21日龄体重 Body weight at d21 (kg)	6.25±1.20	5.82±0.63	0.22	0.001
平均日增重 Average daily gain (kg)	0.16±0.03	0.15±0.03	0.23	0.160
体长 Body length (cm)	29.40±4.34	29.68±3.46	0.19	0.430
体高 Body height (cm)	34.0±4.47	33.09±3.29	0.20	0.810
胸围 Bust (cm)	40.0±2.83	38.55±3.61	0.15	0.160
胸深 Chest depth (cm)	15.60±1.52	14.77±1.93	0.20	0.240
胸宽 Chest width (cm)	10.40±1.14	10.05±1.17	0.85	0.190
管围 Calf circumference (cm)	6.90±0.82	7.27±0.67	0.51	0.070

项目 Item	时间 Time	对照组 Con (μmol·mL^-1)	姜黄素组 Cur (μmol·mL^-1)	P
项目 Item	时间 Time	对照组 Con (μmol·mL^-1)	姜黄素组 Cur (μmol·mL^-1)	组别Group	时间 Time	组别×时间Group ×Time
低密度脂蛋白 LDL	d-21	0.57±0.23	0.44±0.26	0.304	0.088	0.871
	d0	0.40±0.19	0.36±0.12
	d21	0.46±0.16	0.38±0.12
高密度脂蛋白 HDL	d-21	2.38±1.48b	1.95±0.72b	0.312	0.013	0.302
	d0	3.12±0.2a	3.72±0.5a
	d21	1.54±0.48b	2.05±0.81b
游离脂肪酸 NEFA	d-21	0.72±0.09	0.83±0.17a	0.041	0.083	0.082
	d0	0.79±0.07	0.66±0.04b^*
	d21	0.73±0.09	0.56±0.12b^*
总胆固醇 TC	d-21	2.24±0.29a	2.32±0.41a	0.220	0.048	0.511
	d0	1.84±0.51b	1.68±0.46b
	d21	2.49±0.51a	2.05±0.47a
甘油三酯 TG	d-21	0.90±0.27Aa	0.84±0.23Aa	0.149	0.001	0.200
	d 0	0.48±0.17Bb	0.45±0.08Bb
	d21	0.75±0.20a	0.46±0.05b
葡萄糖Glu	d-21	2.31±0.7	2.92±0.83b	0.075	0.048	0.305
	d0	3.05±1.39	4.8±2.17a
	d21	2.68±0.32	2.76±0.4b

Effects of Adding Curcumin to Perinatal Diets on Production Performance, Blood Indexes and Gene Expression of Inflammatory Factors in Goats

RichHTML

PDF

Abstract

Cite this article

share this article

Figures/Tables 9

References 67

Related Articles 15

Metrics

Comments

Recommended 0

[1]	XIAO LiuHua, KANG NaiHui, LI ShuCheng, ZHENG ZhiYuan, LUO RaoRao, CHEN JinYin, CHEN Ming, XIANG MiaoLian. Effect of Methyl Jasmonate on Energy Metabolism and Membrane Lipid Metabolism During Resistance to Botryosphaeria dothidea in Kiwifruit [J]. Scientia Agricultura Sinica, 2024, 57(7): 1377-1393.
[2]	WANG XiaoJun, WANG JinLan, JU ZeLiang, LIANG GuoLing, JIA ZhiFeng, LIU WenHui, MA Xiang, MA JinXiu, LI Wen. Comprehensive Evaluation on Production Performance and Nutritional Quality of Different Varieties of Forage Oat in the Qinghai Lake Area [J]. Scientia Agricultura Sinica, 2024, 57(19): 3730-3742.
[3]	WANG HaiYan, ZHANG ZhenZhen, NI Bo, LIU BeiBei, FENG ZhiXin. Mycoplasma Hyopneumoniae Destroyed the Inflammatory Balance of Respiratory Tract Through Suppressing the Function of SPLUNC1 [J]. Scientia Agricultura Sinica, 2024, 57(1): 216-226.
[4]	LUO WanZhen, WANG Dan, QI HongYue, WANG Tong, LIU Zheng, TIAN Li, DAI XiaoFeng, CHEN JinYin, MIJITI Maihemuti. Identification of Antagonistic Bacterium Strain KRS022 and Its Inhibition Effect on Verticillium dahliae [J]. Scientia Agricultura Sinica, 2023, 56(4): 649-664.
[5]	TAO WenJing, ZHANG ZiTing, LIU Yuan, SONG Dan, LI XiangChen. Inhibitory Effect of N-acetylcysteine on Bisphenol A-Induced Apoptosis and Inflammatory Response in Porcine Kidney Cells [J]. Scientia Agricultura Sinica, 2023, 56(3): 549-558.
[6]	FANG HaoYuan, YANG Liang, WANG HongZhuang, CAO JinCheng, REN WanPing, WEI ShengJuan, YAN PeiShi. Effects of Cross-Ventilation System on Physiology and Production Performance of Beef Cattle in Summer [J]. Scientia Agricultura Sinica, 2022, 55(5): 1025-1036.
[7]	XIAO GuiHua,WEN Kang,HAN Jian,HAO ChenXing,YE RongChun,ZHU YiChi,XIAO ShunYuan,DENG ZiNiu,MA XianFeng. Effects of Calcium on Growth and Development of Poncirus trifoliata and Resistance to Citrus Canker [J]. Scientia Agricultura Sinica, 2022, 55(19): 3767-3778.
[8]	YAN DuoZi,CAI Ni,WANG Feng,NONG XiangQun,WANG GuangJun,TU XiongBing,ZHANG ZeHua. Expression in vitro of Metarhizium anisopliae Adhesin MAD1 and Its Effect on Inducing Response in Peanut [J]. Scientia Agricultura Sinica, 2021, 54(4): 744-753.
[9]	YANG NingZhi,LI Ting,WANG Yan,CHEN Zhuo,MA YiCheng,REN QiangLin,LIU JiaJia,YANG HuiGuo,YAO Gang. Comparison of Growth Physiology and Gut Microbiota Between Healthy and Diarrheic Lambs in Pre- and Post-Weaning Period [J]. Scientia Agricultura Sinica, 2021, 54(2): 422-434.
[10]	MIAO JianJun,PENG ZhongLi,GAO YanHua,BAI Xue,XIE XinTing. Effects of Dietary Small Peptides on Production Performance and Expression of PepT1 mRNA in Digestive Tract of Fattening Yaks [J]. Scientia Agricultura Sinica, 2020, 53(23): 4950-4960.
[11]	CHEN LiJing,CHEN Zhuo,LI Na,SUN YaWei,LI HongBo,SONG WenWen,ZHANG Yang,YAO Gang. Comparison of the Carcass and Beef Quality Traits with the Expression of the Lipid Metabolism Related Genes Between Xinjiang Brown Cattle and Angus Beef Cattle [J]. Scientia Agricultura Sinica, 2020, 53(22): 4700-4709.
[12]	XIAO ZhiXin,WANG Yang,LIU GuoFu,GONG Hao,LI DanDan,GONG Lin,BAI ZhenJian,CUI GuoWen. Effects of Fertilizing Time in Early Spring on Alfalfa (Medicago sativa) Production Performance and Nutritional Quality in Mollisol Area in Cold Region [J]. Scientia Agricultura Sinica, 2020, 53(13): 2668-2677.
[13]	WANG Bei,CHANG HuaSong,SU SongKun,SUN LiPing,WANG Kai. Antioxidative and Anti-inflammatory Activities of Ethanol Extract of Geopropolis from Stingless Bees [J]. Scientia Agricultura Sinica, 2019, 52(5): 939-948.
[14]	ZHANG Chen, TAN XiuWen, WEI Chen, ZHANG XiangLun, JIN Qing, LIU GuiFen, LIU XiaoMu, WAN FaChun. Protective Effect of Astaxanthin on Inflammatory Injury of Endometrial Cells in Bovine [J]. Scientia Agricultura Sinica, 2019, 52(17): 3049-3058.
[15]	LI Zhen,LIU ZhiYong,JIANG WuJun,HE XuJiang,YAN WeiYu,ZHANG LiZhen,ZENG ZhiJiang. Effects of Natural Bee Bread on Blood Lipid, Antioxidation and Immune Function in Rats with Hyperlipidemia [J]. Scientia Agricultura Sinica, 2019, 52(16): 2912-2920.