植物病原黄单胞菌DSF信号依赖的群体感应机制及调控网络

doi:10.3864/j.issn.0578-1752.2013.14.007

Abstract

Abstract: It is now clear that quorum sensing (QS) is one of the most important cell-cell communications in bacteria and this community-wide genetic regulatory mechanism is involved in the regulation of many important biological activities. Since the 1980s, several types of QS signals have been identified. The diffusible signal factor (DSF)，which was originally identified in Xanthomonas campestris pv. campestris (Xcc), represents another interesting type of QS signals found in Gram-negative bacteria. The rapid progress over the last 10 years has identified the chemical structures of the QS signal DSF, established the DSF regulon, and unveiled the general signaling pathways and mechanisms. RpfF is a key enzyme for DSF biosynthesis, which is modulated by a novel autoinduction mechanism involving protein-protein interaction between the DSF synthase RpfF and the sensor RpfC. DSF signal is sensed by RpfC/RpfG two component system and the signal sensing is coupled to intracellular regulatory networks through a second messenger cyclic di-GMP and a global regulator Clp. Genomic and genetic analyses show that the DSF signal regulates diverse biological functions including virulence, biofilm dispersal, and ecological competence. Evidence is emerging that the DSF QS system is conserved in a range of plant and human bacterial pathogens.

Key words: Xanthomonas , quorum sensing , DSF

ZHOU Lian, WANG Xing-Yu, HE Ya-Wen. DSF Signal-Dependent Quorum Sensing in Plant Pathogenic Bacteria Xanthomonas[J].Scientia Agricultura Sinica, 2013, 46(14): 2910-2922.

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