苯并咪唑氨基甲酸酯类药物抗猪囊尾蚴的作用靶点

Scientia Agricultura Sinica ›› 2007, Vol. 40 ›› Issue (5): 1024-1032 .

• ANIMAL SCIENCE·VETERINARY SCIENCERE·SOURCE INSECT • Previous Articles Next Articles

Target Position and Effective Mechanism of benzimidazole carbamate against Cysticerci cellulosae

东北农业大学生命科学学院

Received:2006-03-23 Revised:1900-01-01 Online:2007-05-10 Published:2007-05-10

Abstract

Abstract: Using the technique to detect enzyme activity and metabolite content, the activity of key enzyme in pathway of energy metabolism was studied after drugs were applied. The target position of drug benzimidazole carbamate against Cysticerci cellulosae is fumaric reductase（FR）complex. The effective mechanism is the inhibition of uptaking glucose, noncompetitive inhibition of activity of fumaric reductase（FR）complex, at last disorder of energy metabolism, burnout of energy, and lead to death of Cysticerci cellulosae.

Key words: Cysticerci cellulosae, target position, effective mechanism, energy metabolism

. Target Position and Effective Mechanism of benzimidazole carbamate against Cysticerci cellulosae[J].Scientia Agricultura Sinica, 2007, 40(5): 1024-1032 .

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