肌肉发育相关LncRNA的研究进展

doi:10.3864/j.issn.0578-1752.2014.20.016

Abstract

Abstract: It is well known that the growth traits are complex traits which are jointly or mutually affected by genetic and environmental factors. Although the genome-wide association analyses can be used to analyze all genes on the genome and screen out SNPs associated with certain traits, it is hardly and comprehensively to evaluat the exact role of one gene. One of the goals of breeders is to find the precise gene associated with growth and development, the researches on gene expression and regulation in the past were mainly through the regulation of gene transcription which are mediated by transcription factors, and the protein-coding genes were of the biggest concern, and so the RNA once thought to be transition between proteins and DNA , but the role of RNA in the process of life is far more than people imagine, especially long noncoding RNA (LncRNA) which was recently discovered. LncRNA played a key role in almost all important life events, such as cell proliferation and differentiation, ontogeny, signal transduction, stem cell maintenance and metabolism and so on. It also could regulate the expression of genes on the epigenetic level, the level of transcription and post-transcriptional level, etc., and closely related to the occurrence of many major human diseases. The long noncoding RNA is longer than 200 nt and does not show the potential of coding protein. LncRNA exerts its biological function through multiple mechanisms, which participates in X chromosome silencing, genomic imprinting, chromatin modification, transcriptional activation, transcriptional interference, nuclear transport and other important regulatory process. And LncRNA relates to epigenetic regulation, transcriptional regulation and post-transcriptional regulation. Through in-depth understanding of LncRNA function to adjust the depth LncRNA new molecular pathways regulating muscle development and differentiation through myogenic factor, a new perspective to examine and explain the molecular events mammalian myogenic, and to find new LncRNA molecules in muscle tissue related to growth and development, and to find the LncRNA molecular which are closely related to growth and development and biological function of the target gene in-depth study, and to clarify the molecular mechanisms of LncRNA regulation in muscle growth and development, and it’s the main contents of the genetic breeding researches in terms of muscle development. This article focused the research progress on LncRNA’ s role in mammalian development, cell growth, differentiation and proliferation.

Key words: LncRNA, mammals, muscular growth and development, cells, proliferation, differentiation

WEI Cai-hong, WU Ming-ming, LIU Rui-zao, ZHAO Fu-ping, ZHANG Li, DU Li-xin. Research Progress in Muscular Growth and Development of Long Noncoding RNAs[J].Scientia Agricultura Sinica, 2014, 47(20): 4078-4085.

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