Scientia Agricultura Sinica ›› 2012, Vol. 45 ›› Issue (16): 3382-3390.doi: 10.3864/j.issn.0578-1752.2012.16.018

• ANIMAL SCIENCE·RESOURCE INSECT • Previous Articles     Next Articles

Effects of Feeding Purified Zearalenone Contaminated Diets with or Without Modified Montmorillonite on Immunological Measurements of Postweaning Piglets

 JIANG  Shu-Zhen, YANG  Wei-Ren, YANG  Zai-Bin, WANG  Shu-Jing, LIU  Fa-Xiao, Chi   

  1. 1.山东农业大学动物科技学院，山东泰安 271018，中国
    2.Amlan International, Chicago, Illinois, The United States
  • Received:2011-12-18 Online:2012-08-15 Published:2012-05-25

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Abstract: 【Objective】The aims of the present study were to investigate the toxicity of zearalenone (ZEA) on haematology, lymphocyte subset in peripheral blood, serum immunoglobulin and swine plague antibody titer production of piglets, and the efficacy of Calibrin-Z in preventing ZEA-induced adverse effects was also evaluated. 【Method】The piglets were randomly divided into 6 treatment groups and fed individually in a metabolic cage for 22 days after 7-d adaptation. Piglets in group 1 were fed with basal diet only (Control). Piglets in group 2 were fed with basal diet+1.0 g•kg-1 Calibrin-Z, that in group 3 were fed with basal diet+1.0 mg•kg-1 ZEA, that in group 4 were fed with basal diet + 1.0 mg•kg-1 ZEA + 1.0 g•kg-1 Calibrin-Z, that in group 5 were fed with basal diet + 1.0 mg•kg-1 ZEA + 2.0 g•kg-1 Calibrin-Z, and that in group 6 were fed with basal diet + 1.0 mg•kg-1 ZEA + 4.0 g•kg-1 Calibrin-Z. 【Result】Piglets fed ZEA contaminated diet without Calibrin-Z showed significant decreases in platelet, lymphocyte rato, hemoglobin, CD4+ and CD8+ in peripheral blood, serum IgG and swine plague antibody titer production at 21-d when compared with the control (P＜0.05). The evident improved effect was observed when addition of 2.0 to 4.0 g Calibrin-Z/kg diet in 1.0 mg•kg-1 ZEA contaminated diet. Platelet, lymphocyte rato, hemoglobin, and serum IgG (P＜0.05) showed a linear higher effect with increased Calibrin-Z (P＜0.05).【Conclusion】The above findings indicated that ZEA at a level of 1.0 mg•kg-1 was sufficient to induce immunotoxicity of piglets. Addition of 2.0 to 4.0 g Calibrin-Z/kg diet in 1.0 mg•kg-1 ZEA contaminated diet can effectively protect against the detrimental effects of the ZEA feeding. These results may have implications for humans health and animals production consuming ZEA-contaminated food or feed.

Key words: piglet, zearalenone, modified montmorillonite, haematology, lymphocyte subsets

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