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Journal of Integrative Agriculture  2019, Vol. 18 Issue (4): 729-747    DOI: 10.1016/S2095-3119(18)61976-8
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Progress and prospects of noncoding RNAs in insects
LI Mei-zhen1, XIAO Hua-mei2, HE Kang1, LI Fei1 
1 Ministry of Agriculture Key Lab of Molecular Biology of Crop Pathogens and Insects, Institute of Insect Sciences, College of Agriculture and Biotechnology, Zhejiang University, Hangzhou 310058, P.R.China
2 College of Life Sciences and Resource Environment, Yichun University, Yichun 336000, P.R.China
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With the rapid development of high-throughput sequencing technology and bioinformatics algorithms, great progress has been made in the field of noncoding RNA (ncRNA) in the last decade.  RNA molecules have been regarded only as a messenger between DNA and protein for decades, but now they have new roles in the biological process as ncRNAs.  A growing number of ncRNAs have been identified in insects from the RNA-Seq data of small RNA libraries or transcriptomes.  ncRNAs have varied regulatory functions at the epigenetic, transcriptional, or post-transcriptional levels, and participate in almost all types of biological processes.  Here, we review the research progress of four kinds of ncRNAs, including microRNA (miRNA), Piwi-interacting RNA (piRNA), circular RNA (circRNA), and long noncoding RNA (lncRNA) in insects.  The discovery, biogenesis mechanisms, and regulatory functions of these ncRNAs are presented here to provide a comprehensive understanding of insect ncRNAs and to promote the application of ncRNAs in insect pest control. 
Keywords:  miRNA        piRNA        circRNA        lncRNA        biogenesis        prediction        regulatory functions  
Received: 25 December 2017   Accepted: 01 April 2019
Fund: The study was supported by the National Key Research and Development Program (2017YFD0200900, 2017YFD0200904, 2017YFC1200602 and 2016YFC1200600), and the National Natural Science Foundation of China (31772238, 31760514 and 31701785).
Corresponding Authors:  Correspondence XIAO Hua-mei, E-mail:; LI Fei, E-mail:   
About author:  LI Mei-zhen, E-mail:;

Cite this article: 

LI Mei-zhen, XIAO Hua-mei, HE Kang, LI Fei. 2019. Progress and prospects of noncoding RNAs in insects. Journal of Integrative Agriculture, 18(4): 729-747.

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