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Journal of Integrative Agriculture  2017, Vol. 16 Issue (04): 753-761    DOI: 10.1016/S2095-3119(16)61530-7
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Recent advances in understanding the role of miRNAs in exosomes and their therapeutic potential
MIAO Xiang-yang

Institute of Animal Sciences, Chinese Academy of Agricultural Sciences, Beijing 100193, P.R.China

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Abstract  MicroRNAs (miRNAs) are small endogenous non-protein coding RNAs that range in size from 19–25 nucleotides.  Thousands of miRNA genes have been identified in a variety of organisms, suggesting genetic exchange and distribution among species.  miRNAs negatively regulate gene expression by binding to the 3´-untranslated regions (3´-UTRs) of their target genes and play an important role in growth, development and the occurrence of diseases.  In this review, we summarize the recent advances in the understanding of the role of miRNAs in exosomes and their therapeutic potential, as well as provide an overview of the basic characteristics of miRNAs.
Keywords:  miRNA      gene expression      gene regulation      gene transcription      exosomes      non-coding RNA  
Received: 13 April 2016   Accepted:

This work was supported by a grant from the Major Science and Technology Project of New Variety Breeding of Genetically Modified Organisms (2009ZX08008-004 and 2008ZX08008-003), the National High Technology Research Development Program of China (863 Program, 2008AA10Z140), the National Natural Science Foundation of China (30571339), the Agricultural Science and Technology Innovation Program (ASTIP-IAS05), the Innovation Research Foundation of Chinese Academy of Agricultural Sciences (2004-CAAS-1), and the Basic Research Fund for Central Public Research Institutes of Chinese Academy
of Agricultural Sciences (Y2016JC22, 2013ywf-zd-2).

Corresponding Authors:  MIAO Xiang-yang, Tel: +86-10-62895663, E-mail:    

Cite this article: 

MIAO Xiang-yang. 2017. Recent advances in understanding the role of miRNAs in exosomes and their therapeutic potential. Journal of Integrative Agriculture, 16(04): 753-761.

MicroRNAs (miRNAs) are small endogenous non-protein coding RNAs that range in size from 19–25 nucleotides.  Thousands of miRNA genes have been identified in a variety of organisms, suggesting genetic exchange and distribution among species.  miRNAs negatively regulate gene expression by binding to the 3´-untranslated regions (3´-UTRs) of their target genes and play an important role in growth, development and the occurrence of diseases.  In this review, we summarize the recent advances in the understanding of the role of miRNAs in exosomes and their therapeutic potential, as well as provide an overview of the basic characteristics of miRNAs. 
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