小麦抗病机制研究进展与抗性创新利用策略

doi:10.3864/j.issn.0578-1752.2026.16.007

Abstract

Abstract:

Wheat (Triticum aestivum) remains vital to global food security, yet diverse pathogens constantly threaten its stable production. To address these threats, the identification and utilization of resistant genetic resources is the most effective and eco-friendly approach to manage disease epidemics. Based on a systematic review of the molecular mechanisms of wheat immunity, this paper compares the infection strategies of biotrophic and necrotrophic pathogens and elucidates the evolutionary arms race between wheat and its pathogens. Particular emphasis is placed on key immune regulatory mechanisms, including resistosome assembly and allele-specific evolution, modular cooperation mediated by kinase-integrated immune receptors, and host physiological homeostasis reprogramming driven by non-canonical resistance genes. In addition, the molecular basis by which pathogen effectors promote susceptibility through hijacking host immune pathways or exploiting hypersensitive response-associated cell death is discussed. Building upon these mechanistic insights, we summarize current strategies for resistance resource discovery and precision improvement, including the construction of panoramic resistance-gene atlases, the exploitation of novel resistance resources from wild relatives, and receptor optimization through targeted editing of key genetic loci. In response to the continuing evolution of pathogen populations and the increasing prevalence of multiple concurrent diseases, we further propose several emerging directions for resistance improvement, including the decoupling of immune activation from cell death, the evolution-guided design of universal immune receptors, and the establishment of multi-kingdom immune ecological barriers. These concepts provide a theoretical framework and technical foundation for the rational design of broad-spectrum and durable disease resistance in wheat.

Key words: wheat, disease resistance gene, resistance and susceptibility mechanism, improvement of disease resistance

WU JianHui, ZENG QingDong, LIU ShengJie, WANG XiaoJie, HAN DeJun, KANG ZhenSheng. Advances in Mechanisms and Innovative Improvement Strategies for Wheat Disease Resistance[J].Scientia Agricultura Sinica, 2026, 59(16): 3556-3576.

Figures/Tables 5

Fig. 1

Fig. 2

Table 1

Cloned disease resistance genes in wheat"

基因Gene	蛋白Protein	位点Loci	供体Donor	病害Disease
Yr5a/b/x	BED-NLR	2BL	斯贝尔脱小麦T. spelta；普通小麦T. aestivum	条锈病Stripe rust (Pst)
Yr6¹	CNL pair	7BL	普通小麦T. aestivum	条锈病Stripe rust (Pst)
Yr7	BED-NLR	2BL	普通小麦T. aestivum	条锈病Stripe rust (Pst)
Yr9	CNL	1RS	黑麦S. cereale	条锈病Stripe rust (Pst)
YrNAM (Yr10)	NAM-ZnF-BED	1BS	普通小麦T. aestivum	条锈病Stripe rust (Pst)
Yr15 (WTK1)	KD-PKD	1BS	野生二粒小麦T. dicoccoides	条锈病Stripe rust (Pst)
Yr26	DTMP	1BL	硬粒小麦T. durum	条锈病Stripe rust (Pst)
Yr27²	CNL	2BS	普通小麦T. aestivum	条锈病Stripe rust (Pst)
Yr28/AS2388R; YrAet672	CNL	4DS	山羊草Ae. tauschii	条锈病Stripe rust (Pst)
Yr36 (WKS1)	KD-START	6BS	野生二粒小麦T. dicoccoides	条锈病Stripe rust (Pst)
Yr84/TD121	CNL and NL pair	1BS	野生二粒小麦T. dicoccoides	条锈病Stripe rust (Pst)
YrKB	PH-START-EDR2	7BL	普通小麦T. aestivum	条锈病Stripe rust (Pst)
YrU1	ANK-NLR-WRKY	5AL	乌拉尔图小麦T. urartu	条锈病Stripe rust (Pst)
Lr1	CNL	5DL	普通小麦T. aestivum	叶锈病Leaf rust (Pt)
Lr10-Rga2	CNL and CNL pair	1AS	普通小麦T. aestivum	叶锈病Leaf rust (Pt)
Lr13 (Ne2)²	CNL	2BS	普通小麦T. aestivum	叶锈病Leaf rust (Pt)
Lr14a	Ankyrin TM protein	7BL	普通小麦T. aestivum	叶锈病Leaf rust (Pt)
Lr21	CNL	1DS	山羊草Ae. tauschii	叶锈病Leaf rust (Pt)
Lr22a	CNL	2DS	山羊草Ae. tauschii	叶锈病Leaf rust (Pt)
Lr30	CNL	4AS	硬粒小麦T. durum	叶锈病Leaf rust (Pt)
Lr39	KD-KD-MSP-WD40	2DS	山羊草Ae. tauschii	叶锈病Leaf rust (Pt)
Lr42	CNL	1DS	山羊草Ae. tauschii	叶锈病Leaf rust (Pt)
Lr47	CNL	7S#1S	斯贝尔脱山羊草Ae. speltoides	叶锈病Leaf rust (Pt)
Lr9/Lr58 (WTK6)³	KD-PKD-vWA	6BL	小伞山羊草Ae. umbellulata	叶锈病Leaf rust (Pt)
Rga2	NLR-ID	1DS	普通小麦T. aestivum	叶锈病Leaf rust (Pt)
AcRLK2P-1	LRR-RK	2PL	冰草Ag. cristatum	叶锈病Leaf rust (Pt)
Sr6	BED-NLR	2DS	普通小麦T. aestivum	秆锈病Stem rust (Pgt)
Sr9	CNL	2BL	硬粒小麦T. durum	秆锈病Stem rust (Pgt)
Sr13	CNL	6AL	硬粒小麦T. durum	秆锈病Stem rust (Pgt)
Sr21	CNL	2A^mL	一粒小麦T. monococcum	秆锈病Stem rust (Pgt)
Sr22a/b⁴	CNL	7A^bL; 7A^mL	野生一粒小麦T. boeoticum；一粒小麦T. monococcum	秆锈病Stem rust (Pgt)
Sr26	CNL	6Ae#1L	十倍体长穗偃麦草Th. ponticum	秆锈病Stem rust (Pgt)
Sr27	CNL	3RS	黑麦S. cereale	秆锈病Stem rust (Pgt)
Sr33	CNL	1DS	山羊草Ae. tauschii	秆锈病Stem rust (Pgt)
Sr35	CNL	3A^mL	一粒小麦T. monococcum	秆锈病Stem rust (Pgt)
Sr43	KD-DUFs	7EL	二倍体长穗偃麦草Th. elongatum	秆锈病Stem rust (Pgt)
Sr45	CNL	1DS	山羊草Ae. tauschii	秆锈病Stem rust (Pgt)
Sr46	CNL	2DS	山羊草Ae. tauschii	秆锈病Stem rust (Pgt)
Sr50	CNL	1RS	黑麦S. cereale	秆锈病Stem rust (Pgt)
Sr60 (WTK2)	KD-KD	5A^mS	一粒小麦T. monococcum	秆锈病Stem rust (Pgt)
Sr61	CNL	6Ae#3L	十倍体长穗偃麦草Th. ponticum	秆锈病Stem rust (Pgt)
Sr62 (WTK5)	KD-PKD	1S^shS	沙融山羊草Ae. sharonensis	秆锈病Stem rust (Pgt)
Sr66 (TA1662)	CNL	1DS	山羊草Ae. tauschii	秆锈病Stem rust (Pgt)
Sr8155B1	CNL	6AS	硬粒小麦T. durum	秆锈病Stem rust (Pgt)
Pm1a	CNL	7AL	普通小麦T. aestivum	白粉病Powdery mildew (Bgt)
Pm2	CNL	5DS	山羊草Ae. tauschii	白粉病Powdery mildew (Bgt)
Pm3a/b/d	CNL	1AS	普通小麦T. aestivum	白粉病Powdery mildew (Bgt)
Pm4b⁵	KD-MCTP	2AL	波斯小麦T. carthlicum	白粉病Powdery mildew (Bgt)
Pm5e¹	CNL pair	7BL	普通小麦T. aestivum	白粉病Powdery mildew (Bgt)
Pm6/52	CNL	2GL	提莫菲维小麦T. timopheevii	白粉病Powdery mildew (Bgt)
Pm8, Pm17	CNL	1RS	黑麦S. cereale	白粉病Powdery mildew (Bgt)
Pm12	CNL	6SS	斯贝尔脱山羊草Ae. speltoides	白粉病Powdery mildew (Bgt)
Pm13	HeLo-KD	3S^lS	高大山羊草Ae. longissima	白粉病Powdery mildew (Bgt)
Pm21	CNL	6VS	簇毛麦D. villosum	白粉病Powdery mildew (Bgt)
Pm24 (WTK3)⁶	KD-PKD	1DS	普通小麦T. aestivum	白粉病Powdery mildew (Bgt)
Pm26	CNL pair	3BL	野生二粒小麦T. dicoccoides	白粉病Powdery mildew (Bgt)
Pm36 (WTK7)	KD-KD-TM	5BL	野生二粒小麦T. dicoccoides	白粉病Powdery mildew (Bgt)
Pm37⁴	CNL	7AL	普通小麦T. aestivum	白粉病Powdery mildew (Bgt)
Pm41	CNL	3BL	野生二粒小麦T. dicoccoides	白粉病Powdery mildew (Bgt)
SuPm55-Pm55a/b	CNL	5VS	簇毛麦D. villosum	白粉病Powdery mildew (Bgt)
Pm57 (WTK6b)³	KD-PKD-vWA	2SL	西尔斯山羊草Ae. searsii	白粉病Powdery mildew (Bgt)
Pm60a/b; MlIW18/172	CNL	7AL	乌拉尔图小麦T. urartu；野生二粒小麦T. dicoccoides	白粉病Powdery mildew (Bgt)
Pm68/WR183/MlIW39	CNL pair	6BL	野生二粒小麦T. dicoccoides	白粉病Powdery mildew (Bgt)
Pm69	CNL	6BL	野生二粒小麦T. dicoccoides	白粉病Powdery mildew (Bgt)
Pm6Sl	BED-NLR	6S^lL	高大山羊草Ae. longissima	白粉病Powdery mildew (Bgt)
PmAeu1	CNL	2UL	小伞山羊草Ae. umbellulata	白粉病Powdery mildew (Bgt)
PmTR1, PmTR3	CNL	6RS	黑麦S. cereale	白粉病Powdery mildew (Bgt)
WTK4	KD-PKD	7DS	山羊草Ae. tauschii	白粉病Powdery mildew (Bgt)
Yr18/Lr34/Sr57/Pm38	ABC transporter	7DS	普通小麦T. aestivum	兼抗Multiple diseases resistance (Pt/Pst/Pgt/Bgt)
Yr46/Lr67/Sr55/Pm46	Hexose-proton symporter	4DL	普通小麦T. aestivum	兼抗Multiple diseases resistance (Pt/Pst/Pgt/Bgt)
Lr85/Yr87	CNL	6S^shS/6S^lS	沙融山羊草Ae. sharonensis；高大山羊草Ae. longissima	兼抗Multiple diseases resistance (Pt/Pst)
Fhb1	His	3BS	普通小麦T. aestivum	赤霉病Fusarium head blight (Fg)
Fhb7	GST	7EL	二倍体长穗偃麦草Th. elongatum	赤霉病Fusarium head blight (Fg)
Stb15	LecRK	6AS	普通小麦T. aestivum	叶枯病Septoria tritici blotch (Zt)
Stb16q	CRK	3DS	山羊草Ae. tauschii	叶枯病Septoria tritici blotch (Zt)
Stb6	WAK	3AS	普通小麦T. aestivum	叶枯病Septoria tritici blotch (Zt)
Snn1	WAK	1BS	普通小麦T. aestivum	颖枯病Septoria nodorum blotch (Pn)
Snn3	KD-MSP	5DS	山羊草Ae. tauschii	颖枯病Septoria nodorum blotch (Pn)
Tsn1	KD-NBS-LRR	5BL	普通小麦T. aestivum	褐斑病Tan spot (Bs)
Rmg7⁵	KD-MCTP	2AL	栽培二粒小麦T. dicoccum	麦瘟病Wheat blast (Po)
Rmg8	KD-MCTP	2BL	普通小麦T. aestivum	麦瘟病Wheat blast (Po)
Rwt3	CNL	1DS	普通小麦T. aestivum	麦瘟病Wheat blast (Po)
RWT4⁶	KD-PKD	1DS	山羊草Ae. tauschii	麦瘟病Wheat blast (Po)

Table 1

Fig. 3

Fig. 4

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