Scientia Agricultura Sinica ›› 2011, Vol. 44 ›› Issue (23): 4874-4881.doi: 10.3864/j.issn.0578-1752.2011.23.014

• ANIMAL SCIENCE·RESOURCE INSECT • Previous Articles     Next Articles

Effects of Diets Supplemented with Nano-CuO and High Level of Zinc Sulfate on Copper and Zinc Contents of Visceral Tissues of Chickens

 PAN  Na, ZHU  Feng-Hua, WANG  You-Ling, CHEN  Fu, ZHAO  Cai-Bing, ZHU  Lian-Qin   

  1. 1.青岛农业大学动物科技学院，山东青岛 266109
    2.山东省农业科学院家禽研究所，济南250100
  • Received:2010-11-19 Online:2011-12-01 Published:2011-05-30

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Abstract: 【Objective】 In order to discover the interaction between Zn2+ and nano-CuO in the digestive tract of chickens, an experiment was conducted to determine the effect of high zinc (ZnSO4•7H2O) and normal copper (nano-CuO) diets on copper and zinc contents of visceral tissues in chickens.【Method】One hundred and twenty one-day-old White Leghorn SPF chickens were divided into 4 groups randomly, and five replicates for each group. The basal diet was supplemented with nano-CuO to supply the copper level ats 8 mg•kg-1. The chickens of control group were fed with basal diet. The chickens of trial groups were fed with diets supplemented with ZnSO4•7H2O to supply the zinc level at 250 mg•kg-1, 500 mg•kg-1 and 1 000 mg•kg-1, respectively.【Result】The results showed that when the chickens were fed with diets containing zinc at 250 mg•kg-1, 500 mg•kg-1 and 1 000 mg•kg-1, the zinc and metallotionein contents of liver, proventriculus, duodenum and jejunum were significantly higher than the control group (P＜0.01 or P＜0.05), and the copper contents of duodenum were significantly higher than the control group (P＜0.01). When the diets containing zinc at 1 000 mg•kg-1 were fed to chickens, the copper contents of jejunum were significantly higher than the control group and when the diets containing zinc at 250 mg•mg-1 and 500 mg•mg-1 were fed to chickens (P＜0.01). On 42nd day, when the chickens were fed with diets containing zinc at 500 mg•kg-1 and 1 000 mg•kg-1, the copper contents of liver were significantly higher than the control group and when the chickens were fed with diets containing zinc at 250 mg•mg-1 (P＜0.01). The zinc levels of the diets had a remarkable positive correlation with zinc contents of liver, proventriculus, duodenum and jejunum (P＜0.05), had a remarkable positive correlation with copper contents of duodenum and jejunum (P＜0.05), and had a positive correlation with copper contents of liver (P＞0.05). There was a positive correlation between zinc levels of the diets and the metallothionein contents of duodenum, jejunum and proventriculus (P＞0.05), a significant positive correlation between metallothionein and copper contents of the liver (P＜0.01), and a positive correlation between metallothionein and copper content of duodenum and jejunum (P＞0.05).【Conclusion】It is concluded that the absorption of nano-CuO is not antagonized by high level of zinc of diets supplemented with ZnSO4•7H2O in the intestines of chickens, the nano-Cuo can be absorbed in the form of nanoparticle.

Key words: nano-CuO, SPF chicken, copper, zinc, metallothionein

[1]Zhang X Q, Zhang K Y, Ding X M, Bai S P. Effects of dietary supplementation with copper sulfate or tribasic copper chloride on carcass characteristics, tissular nutrients deposition and oxidation in broilers. Journal of Nutrition, 2009, 8(8): 1114-1119.

[2]Stansbury W F, Tribble L F, Jr Orrjr D E. Effect of chelated copper sources on performance of nursery and growing pigs. Journal of Animal Science, 1990, 68(5): 1381-1387.

[3]Coffey R D, Cromwell G L, Monegue H J. Efficacy of a copper-lysine chelate as growth promotant in weanling swine. Journal of Animal Science, 1992, 72(Suppl.): 2880-2886.

[4]田相迪, 朱风华, 孙金全, 李曙明, 朱连勤. 不同剂量纳米氧化铜对肉鸡生长性能的影响. 饲料研究, 2007, 7: 41-44.

Tian X D, Zhu F H, Sun J Q, Li S M, Zhu L Q. Effects of different dose nano-CuO on the growth performance of broiler chickens. Feed Research, 2007, 7: 41-44. (in Chinese)

[5]田相迪, 朱风华, 孙金全, 李曙明, 朱连勤. 不同剂量纳米氧化铜对肉鸡血清和组织中铜含量的影响. 微量元素与健康研究, 2007, 24(6): 3-7.

Tian X D, Zhu F H, Sun J Q, Li S M, Zhu L Q. Effects of different dose nano-CuO on the contents of copper in serum and tissue of broiler chickens. Studies of Trace Elements and Health, 2007, 24(6): 3-7. (in Chinese)

[6]Kuzuya T, Hasegawa T, Ogura Y, Nabeshima T. The effects of transmucosal fluid movement on zinc and copper absorption from rat small intestine. Clinical Experimental Pharmacology Physiology, 1998, 25(6): 412-416.

[7]L’abbé M Y, Fischer P W F. The effects of high dietary zinc and copper deficiency on the activity of copper-requiring metalloenzymes in the growing rat. The Journal of Nutrition, 1984, 14: 813-822.

[8]朱赓伯. 金属硫蛋白的生物学特性及生理作用. 生命的化学, l995, 15(l): 23-26.

Zhu G B. The biological characteristics and physiological action of metallothionein. Chemistry of Life, l995, 15(l): 23-26. (in Chinese)

[9]金少华, 吴训贤. 饲料补锌对大鼠铁、铜代谢的影响. 营养学报, 1997, 19(l): 94-96.

Jin S H, Wu X X. Effect of zinc supplementation in feed on metabolism of iron and copper in rats. Acta Nutrimenta Sinica, 1997, 19(l): 94-96. (in Chinese)

[10]Underwood E J. Trace Elements in Human and Animal Nutrition: 4 ed. New York: Academic Press, 1977.

[11]Murthy L, Klevay L M, Petering H G. Interrelationships between zinc and copper nutrition in the rat. The Journal of Nutrition, 1974, 104: 1458-1465.

[12]Oestreicher P, Cousins R J. Copper and zinc absorption in the rat: mechanism of mutual antagonism. The Journal of Nutrition, 1985, 115: 159-166.

[13]隋菲菲, 朱连勤, 朱风华, 常顺华, 王友令, 杨澄峰. 纳米氧化铜对SPF鸡组织中铜和锌沉积的影响. 饲料研究, 2010, 5: 43-45.

Sui F F, Zhu L Q, Zhu F H, Chang S H, Wang Y L, Yang C F. Effects of nano-CuO on the contents of copper and zinc in tissue of SPF Chickens. Feed Research, 2010, 5: 43-45. (in Chinese)

[14]Cerovic A I, Miletic D, Blagojevic D, Sobajic S, Vasiljevska M, Poznanic M, Radusinovic M. Effects of low, adeqate and high dietary zinc intake on metabolic interactions between zinc copper and iron in different mongolian gerbil tissues. Acta Veterinaria Brunesis, 2008, 77: 17-23.

[15]Park S Y, Birkhold S G, Kubena L F, Nisbet D J, Ricke S C. Effects of high zinc diets using zinc propionate on molt induction, organs, and postmolt egg production and quality in laying hens. Poultry Science, 2004, 83: 24-23.

[16]Buff C E, Bollinger D W, Ellersieck M R, Brommelsiek W A, Veum T L. Comparison of growth performance and zinc absorption, retention and excretion in weanling pigs fed diets supplemented with zinc-polysacharide or zinc oxide. Journal of Animmal Science, 2005, 83: 2380-2386.

[17]Magee A C, Matione G. Studies on growth, copper metabolism and iron metabolism of rats fed high levels of zinc. The Journal the Nutrition, 1960, 72: 233-242.

[18]Barone A, Ebesh O, Harper R G, Wapnir R A. Placental copper transport in rats: effects of elevated dietary zinc on fetal copper,iron and metallothionein. The Journal of Nutrition, 1998, 128: 1037-1041.

[19]Storey M L, Greger J L. Iron, zinc and copper interactions: chronic versus acute responses of rats. The Journal of Nutrition, 1987, 117: 1434-1442.

[20]Willis M S, Monaghan S A, Miller M L, McKenna R W, Perkins W D, Levinson B S, Bhushan V, Kroft S H. Zinc-induced copper deficiency: a report of three cases initially recognized on bone marrow examination. American Journal of Clinical Pathology, 2005, 123: 125-131.

[21]Horvath J, Beris P, Giostra E, Martin P Y, Burkhard P R. Zinc-induced copper deficiency in Wilson disease. Journal of Neurol Neruosurg Psychiatry, 2010, 81: 1410-1411.

[22]Fischer P W F, Campbell J S, Giroux A. Effects of low copper and high zinc intakes and related changes in Cu, Zn-superoxide dismutase activity on DMBA-induced mammary tumor genesis. Biological Trace Element Research, 1991, 30(1): 65-79.

[23]van Campen D R, Scaife P U. Znic interference with copper absorption in rats. The Journal of Nutrition, 1967, 91: 473-476.

[24]van Campen D R. Copper interference with the intestinal absorption of znic-65 by rats. The Journal of Nutrtrition, 1969, 97: 104-108.

[25]Fischer P W F, Giroux A, L’Abbe M R. The effect of dietary zinc on intestinal copper absorption. American Journal of Clinical Nutrition, 1981, 34: 1670-1675.

[26]Chen W Q, Cheng Y Y, Zhao X L, Li S T, Hou Y, Hong Y. Effects   of zinc on the induction of metallothionein isoforms in hippocampus in stress rats. Experimental Biology and Medicine, 2006, 231: 1564-1568.

[27]Cousins R J, Lee-Ambrose L M. Nuclear zinc uptake and interactions and metallothionein gene expression are influenced by dietary zinc in rats. The Journal of Nutrition, 1992, 122: 56-64.

[28]董菊红, 朱连勤, 朱风华, 孙金全, 杨澄峰. 不同剂量纳米氧化铜对小鼠全血及组织中铜和锌含量的影响. 微量元素与健康研究, 2009, 26(5): 1-5.

Dong J H, Zhu L Q, Zhu F H, Sun J Q, Yang C F. Effects of different dose nano-CuO on the contents of copper and zinc in blood and tissues in mice. Studies of Trace Elements and Health, 2009, 26(5): 1-5. (in Chinese)
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