Abramson J, Adler J, Dunger J, Evans R, Green T, Pritzel A, Ronneberger O, Willmore L, Ballard A J, Bambrick J, Bodenstein S W, Evans D A, Hung C C, O’Neill M, Reiman D, Tunyasuvunakool K, Wu Z, Zemgulyte A, Arvaniti E, Beattie C, et al. 2024. Accurate structure prediction of biomolecular interactions with AlphaFold 3. Nature, 630, 493–500.
Alabd A, Ahmad M, Zhang X, Gao Y H, Peng L, Zhang L, Ni J B, Bai S L, Teng Y W. 2022. Light-responsive transcription factor PpWRKY44 induces anthocyanin accumulation by regulating PpMYB10 expression in pear. Horticulture Research, 9, uhac199.
An J P, Wang X F, Zhang X W, Bi S Q, You C X, Hao Y J. 2019. MdBBX22 regulates UV-B-induced anthocyanin biosynthesis through regulating the function of MdHY5 and is targeted by MdBT2 for 26S proteasome-mediated degradation. Plant Biotechnology Journal, 17, 2223–2383.
An J P, Zhang X W, Bi S Q, You C M, Wang X F, Hao Y J. 2020. The ERF transcription factor MdERF38 promotes drought stress-induced anthocyanin biosynthesis in apple. The Plant Journal, 101, 573–589.
An X H, Tian Y, Chen K Q, Liu X J, Liu D D, Xie X B, Cheng C G, Cong P H, Hao Y J. 2015. MdMYB9 and MdMYB11 are involved in the regulation of the JA-induced biosynthesis of anthocyanin and proanthocyanidin in apples. Plant Cell Physiology, 56, 650–662.
Bai S L, Saito T, Honda C, Hatsuyama Y, Ito A, Moriguchi T. 2014. An apple B-box protein, MdCOL11, is involved in UV-B- and temperature-induced anthocyanin biosynthesis. Planta, 240, 1051–1062.
Bai S L, Tao R Y, Tang Y X, Yin L, Ma Y J, Ni J B, Yan X H, Yang Q S, Wu Z Y, Zeng Y L, Teng Y W. 2019a. BBX16, a B-box protein, positively regulates light-induced anthocyanin accumulation by activating MYB10 in red pear. Plant Biotechnology Journal, 17, 1985–1997.
Bai S L, Tao R Y, Yin L, Ni J B, Yang Q S, Yan X H, Yang F, Guo X P, Li H X, Teng Y W. 2019b. Two B-box proteins, PpBBX18 and PpBBX21, antagonistically regulate anthocyanin biosynthesis via competitive association with Pyrus pyrifolia ELONGATED HYPOCOTYL 5 in the peel of pear fruit. The Plant Journal, 100, 1208–1223.
Bao L, Chen K S, Zhang D, Lin X G, Teng Y W. 2008. An assessment of genetic variability and relationships within Asian pears based on AFLP (amplified fragment length polymorphism) markers. Scientia Horticulturae, 116, 374–380.
Bayer-Császár E, Haag S, Jörg A, Glass F, Hartel B, Obata T, Meyer H E, Brennicke A, Takenaka M. 2017. The conserved domain in MORF proteins has distinct affinities to the PPR and E elements in PPR RNA editing factors. Biochimica et Biophysica Acta (BBA)-Gene Regulatory Mechanisms, 8, 813–828.
Brusch K, Toledo-Ortiz G, Pireyre M, Lohr M, Braatz B, Johansson H. 2020. Identification of BBX proteins as rate-limiting cofactors of HY5. Nature Plants, 6, 921–928.
Castillejo C, Waurich V, Wagner H, Ramos R, Oiza N, Muñoz P, Triviño J C, Caruana J, Liu Z, Cobo N, Hardigan M A, Knapp S J, Vallarino J G, Osorio S, Martín-Pizarro C, Posé D, Toivainen T, Hytönen T, Oh Y, Barbey C R, et al. 2020. Allelic V ariation of MYB10 is the major force controlling natural V ariation of skin and flesh color in strawberry (Fragaria spp.) fruit. The Plant Cell, 32, 3723–3749.
Chagné D, Lin-Wang K, Espley R V, Volz R K, How N M, Rouse S, Brendolise C, Carlisle C M, Kumar S, De SilvaN, Micheletti D, McGhie T, Crowhurst R N, Storey R D, Velasco R, Hellens R P, Gardiner S E, Allan A C. 2013. An ancient duplication of apple MYB transcription factors is responsible for novel red fruit-flesh phenotypes. Plant Physiology, 161, 225–239.
Ding L, Wang S, Song Z T, Jiang Y P, Han J J, Lu S J, Li L, Liu J X. 2018. Two B-box domain proteins, BBX18 and BBX23, interact with ELF3 and regulate thermomorphogenesis in Arabidopsis. Cell Reports, 25, 1718–1728.
Espley R V, Hellens R P, Putterill J, Stevenson D E, Kutty-Amma S, Allan A C. 2017. Red colouration in apple fruit is due to the activity of the MYB transcription factor, MdMYB10. The Plant Journal, 49, 414–427.
Fang H C, Dong Y H, Yue X X, Chen X L, He N B, Hu J F, Jiang S H, Xu H F, Wang Y C, Su M Y, Zhang J, Zhang Z Y, Wang N, Chen X S. 2019a. MdCOL4 interaction mediates crosstalk between UV-B and high temperature to control fruit coloration in apple. Plant Cell Physiology, 60, 1055–1066.
Fang H C, Dong Y H, Yue X X, Hu J F, Jiang S H, Xu H F, Wang Y C, Su M Y, Zhang J, Zhang Z Y, Wang N, Chen X S. 2019b. The B-box zinc finger protein MdBBX20 integrates anthocyanin accumulation in response to ultraviolet radiation and low temperature. Plant Cell Environment, 42, 2090–2104.
Feng S Q, Sun S S, Chen X L, Wu S J, Wang D Y, Chen X S. 2015. PyMYB10 and PyMYB10.1 interact with bHLH to enhance anthocyanin accumulation in pears. PLoS ONE, 10, e0142112.
Feng S Q, Wang Y L, Song Y, Xu Y T, Chen X S. 2010. Anthocyanin biosynthesis in pears is regulated by a R2R3-MYB transcription factor PyMYB10. Planta, 232, 245–255.
Fu Z Z, Shang H Q, Jiang H, Gao J, Dong X Y, Wang H J, Li Y M, Wang L M, Zhang J, Shu Q Y, Chao Y C, Xu M L, Wang R, Wang L S, Zhang H C. 2020. Systematic identification of the light-quality responding anthocyanin synthesis-related transcripts in Petunia petals. Horticultural Plant Journal, 6, 428–438.
Gamble J, Jaeger S R, Harker F R. 2006. Preferences in pear appearance and response to novelty among Australian and New Zealand consumers. Postharvest Biology and Technology, 41, 38–47.
Gangappa S N, Crocco C D, Johansson H, Datta S, Hettiarachchi C, Holm M, Botto J F. 2013. The Arabidopsis B-BOX protein BBX25 interacts with HY5, negatively regulating BBX22 expression to suppress seedling photomorphogenesis. The Plant Cell, 25, 1243–1257.
Gao Y H, Li H X, Wang Z W, Xue H B, Li J Z, Yu W J, Zhang J B, Ni J B, Teng Y W, Bai S L. 2024. Genetic variations at BBX24 and MYB110a loci regulated anthocyanin accumulation in pear bud sports. Horticultural Plant Journal, https://doi.org/10.1016/j.hpj.2024.01.001
Hu Y J, Cheng H, Zhang Y, Zhang J, Niu S Q, Wang X S, Li W J, Zhang J, Yao Y C. 2021. The MdMYB16/MdMYB1-miR7125-MdCCR module regulates the homeostasis between anthocyanin and lignin biosynthesis during light induction in apple. New Phytologist, 231, 1105–1122.
Huang J Y, Zhao X B, Weng X Y, Wang L, Xie W B. 2012. The rice B-Box zinc finger gene family: Genomic identification, characterization, expression profiling and diurnal analysis. PLoS ONE, 7, e48242.
Jiang G X, Li Z W, Song Y B, Zhu H, Lin S, Huang R M, Jiang Y M, Duan X W. 2019. LcNAC13 physically interacts with LcR1MYB1 to coregulate anthocyanin biosynthesis-related genes during litchi fruit ripening. Biomolecules, 9, 135.
Job N, Yadukrishnan P, Bursch K, Datta S, Johansson H. 2018. Two B-Box proteins regulate photomorphogenesis by oppositely modulating HY5 through their diverse C-terminal domains. Plant Physiology, 176, 2963–2976.
Lee B J, Cansizoglu A E, Suel K E, Louis T H, Zhang Z C, Chook Y M. 2006. Rules for nuclear localization sequence recognition by karyopherinβ2. Cell, 126, 543–558.
Li S P, Deng B L, Tian S, Guo M X, Liu H X, Zhao X S. 2021. Metabolic and transcriptomic analyses reveal different metabolite biosynthesis profiles between leaf buds and mature leaves in Ziziphus jujuba mill. Food Chemistry, 347, 129005.
Li Y, Xu P B, Chen G Q, Wu J, Liu Z C, Lian H L. 2020. FvbHLH9 functions as a positive regulator of anthocyanin biosynthesis by forming a HY5-bHLH9 transcription complex in strawberry fruits. Plant and Cell Physiology, 61, 826–837.
Lin-Wang K, Bolitho K, Grafton K, Kortstee A, Karunairetnam S, McGhie T K, Espley R V, Hellens R P, Allan A C. 2010. An R2R3 MYB transcription factor associated with regulation of the anthocyanin biosynthetic pathway in Rosaceae. BMC Plant Biology, 10, 50.
Lippuner V, Cyert M S, Gasser C S. 1996. Two classes of plant cDNA clones differentially complement yeast calcineurin mutants and increase salt tolerance of wild-type yeast. Journal of Biological Chemistry, 271, 12859–12866.
Liu H N, Shu Q, Lin-Wang K, Allan A C, Espley R V, Su J, Pei M S, Wu J. 2021a. The PyPIF5-PymiR156a-PySPL9-PyMYB114/MYB10 module regulates light-induced anthocyanin biosynthesis in red pear. Molecular Horticulture, 1, 14.
Liu X, Li R, Dai Y Q, Chen X S, Wang X Y. 2018. Genome-wide identification and expression analysis of the B-box gene family in the Apple (Malus domestica Borkh.) genome. Molecular Genetics and Genomics, 293, 303–315.
Liu X F, Li S R, Feng X X, Li L L. 2021b. Study on cell wall composition, fruit quality and tissue structure of hardened ‘Suli’ pears (Pyrus bretschneideri Rehd). Journal of Plant Growth Regulation, 40, 5.
Lyu G Z, Li D B, Li S S. 2020. Bioinformatics analysis of BBX family genes and its response to UV-B in Arabidopsis thaliana. Plant Signaling & Behavior, 15, 1782647.
Mao W W, Han Y, Chen Y T, Sun M Z, Feng Q Q, Li L, Liu L P, Zhang K K, Wei L Z, Han Z H, Li B B. 2022. Low temperature inhibits anthocyanin accumulation in strawberry fruit by activating FvMAPK3-induced phosphorylation of FvMYB10 and degradation of Chalcone Synthase 1. The Plant Cell, 34, 1226–1249.
Martínez-Rivas F J, Blanco-Portales R, Pérez-Serratosa M, Ric-Varas P, Guerrero-Sánchez V, Medina-Puche L, Moyano L, Mercado J A, Alseekh S, Caballero J L, Fernie A R, Muñoz-Blanco J, Molina-Hidalgo F J. 2023. FaMYB123 interacts with FabHLH3 to regulate the late steps of anthocyanin and flavonol accumulation during ripening. The Plant Journal, 144, 683–698.
Ni J B, Bai S L, Zhao Y, Qian M J, Tao R Y, Yin L, Gao L, Teng W Y. 2019. Ethylene response factors Pp4ERF24 and Pp12ERF96 regulate blue light-induced anthocyanin biosynthesis in ‘Red Zaosu’ pear fruits by interacting with MYB114. Plant Molecular Biology, 99, 67–78.
Ni J B, Premathilake A T, Gao Y H, Yu W J, Tao R Y, Teng Y W, Bai S L. 2021. Ethylene-activated PpERF105 induces the expression of the repressor-type R2R3-MYB gene PpMYB140 to inhibit anthocyanin biosynthesis in red pear fruit. The Plant Journal, 105, 167–181.
Ou C Q, Zhang X L, Wang F, Zhang L Y, Zhang Y J, Fang M, Wang J H, Wang J X, Jiang S L, Zhang Z H. 2020. A 14 nucleotide deletion mutation in the coding region of the PpBBX24 gene is associated with the red skin of “Zaosu Red” pear (Pyrus pyrifolia White Pear Group): A deletion in the PpBBX24 gene is associated with the red skin of pear. Horticulture Research, 7, 39.
Premathilake A, Ni J B, Bai S L, Yao R Y, Ahmad M, Teng Y W. 2020. R2R3-MYB transcription factor PpMYB17 positively regulates flavonoid biosynthesis in pear fruit. Planta, 252, 59.
Qian M J, Sun Y W, Allan A C, Teng Y W, Zhang D. 2014. The red sport of ‘Zaosu’ pear and its red-striped pigmentation pattern are associated with demethylation of the PyMYB10 promoter. Phytochemistry, 107, 16–23.
Ren Y R, Zhao Q, Yang Y Y, Zhang T N, Wang X F, You C X, Hao Y J. 2021. The apple 14-3-3 protein MdGRF11 interacts with the BTB protein MdBT2 to regulate nitrate deficiency-induced anthocyanin accumulation. Horticulture Research, 8, 22.
Rosenberg O S, Deindl S, Sung R J, Nairn A C, Kuriyan J. 2006. Structure of the autoinhibited kinase domain of CaMKII and SAXS analysis of the holoenzyme. Cell, 123, 849–860.
Song L Y, Wang X L, Han W, Qu Y Y, Wang Z G, Zhai R, Yang C Q, Ma F W, Xu L F. 2020. PbMYB120 negatively regulates anthocyanin accumulation in pear. International Journal of Molecular Sciences, 21, 1528.
Su L, Qi M, Meng D, Yang Q, Wang Y M, Ren F S, Yang L Y, Chen Y C, Liu L Y, Tang M L, Song Y B, Gong L. 2023. Transcriptome analysis reveals the central role of the transcription factor MYB in regulating anthocyanin accumulation in economic grape species (Vitis vinifera). Forests, 14, 416.
Sun Y W, Qian M J, Wu R Y, Niu Q F, Teng Y W, Zhang D. 2014. Postharvest pigmentation in red Chinese sand pears (Pyrus pyrifolia Nakai) in response to optimum light and temperature. Postharvest Biology and Technology, 91, 64–71.
Tao R Y, Yu W J, Gao Y H, Ni J B, Yin L, Zhang X, Li H X, Wang D S, Bai S L, Teng Y W. 2020. Light-induced basic/helix-loop-helix 64 enhances anthocyanin biosynthesis and undergoes CONSTITUTIVELY PHOTOMORPHOGENIC 1-mediated degradation in pear. Plant Physiology, 184, 1684–1701.
Trofimov K, Ivanov R, Eutebach M, Acaroglu B, Mohr I, Bauer P, Brumbarova T. 2019. Mobility and localization of the iron deficiency-induced transcription factor bHLH039 change in the presence of FIT. Plant Direct, 3, e00190.
Tu M X, Fang J H, Zhao R K, Liu X Y, Yin W C, Wang Y, Wang X H, Wang X P, Fang Y L. 2022. CRISPR/Cas9-mediated mutagenesis of VvbZIP36 promotes anthocyanin accumulation in grapevine (Vitis vinifera). Horticulture Research, 9, uhac022.
Vimolmangkang S, Han Y P, Wei G C, Korban S S. 2013. An apple MYB transcription factor, MdMYB3, is involved in regulation of anthocyanin biosynthesis and flower development. BMC Plant Biology, 13, 176.
Wang C Q, Sarmast M K, Jiang J, Dehesh K. 2015. The transcriptional regulator BBX19 promotes hypocotyl growth by facilitating COP1-mediated EARLY FLOWERING3 degradation in Arabidopsis. The Plant Cell, 27, 1128–1139.
Wang F, Chen L, Chen H P, Chen S W, Liu Y P. 2019. Analysis of flavonoid metabolites in citrus peels (Citrus reticulata ‘Dahongpao’) using UPLC-ESI-MS/MS. Molecules, 24, 2680.
Wang M L, Wang Y R, Ding T Y, Yan Z L, Zhou Z, Li C Y, Yao J, Zhang H T. 2023a. Red-TE homozygous alleles of MdMYB10 confer full-red apple fruit skin in a high-temperature region. Horticulturae, 9, 270.
Wang R J, Wang R X, Liu M M, Yuan W W, Zhao Z Y, Liu X Q, Peng Y M, Yang X R, Sun Y, Tang W Q. 2021. Nucleocytoplasmic trafficking and turnover mechanisms of BRASSINAZOLE RESISTANT1 in Arabidopsis thaliana. Proceedings of the National Academy of Sciences of the United States of America, 118, e2101838118.
Wang X F, Shao D N, Liang Q, Feng X K, Zhu Q H, Yang Y L, Liu F, Zhang X Y, Li YJ, Sun J, Xue F. 2023b. A 2-bp frameshift deletion at GhDR encoding a B-BOX protein co-segregatiing with dwarf-red phenotype in Gossypium hirsutum L. Journal of Integrative Agriculture, 22, 2000–2014.
Wang Y C, Xu H F, Wang N, Jiang S H, Liu J X, Wang D Y, Zuo W F, Chen X S. 2017. Molecular cloning and expression analysis of an auxin signaling related gene MdARF3 in red flesh apple. Acta Horticulturae Sinica, 44, 633–643. (in Chinese)
Wang Y Y, Zhang X D, Zhao Y R, Yang J, He Y Y, Li G C, Ma W R, Huang X L, Su J. 2020. Transcription factor PyHY5 binds to the promoters of PyWD40 and PyMYB10 and regulates its expression in red pear ‘Yunhongli No. 1’. Plant Physiology and Biochemistry, 154, 665–674.
Xing Y F, Sun W J, Sun Y Y, Li J L, Zhang J, Wu T, Song T T, Yao Y C, Tian J. 2023. MPK6-mediated HY5 phosphorylation regulates light-induced anthocyanin accumulation in apple fruit. Plant Biotechnology Journal, 21, 283–301.
Yan H, Marquardt K, Indorf M, Jutt D, Kircher S, Neuhaus G, Rodríguez-Franco M. 2011. Nuclear localization and interaction with COP1 are required for STO/BBX24 function during photomorphogenesis. Plant Physiology, 156, 1772–1782.
Yang G Y, Sun M Y, Brewer L, Tang Z K, Nieuwenhuizen N, Cooney J, Xu S Z, Sheng J W, Andre C, Xue C, Rebstock R, Yang B, Chang W J, Liu Y Y, Li J M, Wang R Z, Qin M F, Brendolise C, Allan A C, Espley R V, et al. 2024. Allelic variation of BBX24 is a dominant determinant controlling red coloration and dwarfism in pear. Plant Biotechnology Journal, https://doi.org/10.1111/pbi.14280
Yang S, Liu H D, Wang H B, Zhang H J, Liu F Z. 2019. Molecular cloning and functional characterization of VcNAC072 reveals its involvement in anthocyanin accumulation in blueberry. Scientia Agricultura Sinica, 52, 503–511. (in Chinese)
Yao G F, Gou S S, Zhong T Y, Wei S W, An X, Sun H Y, Sun C, Hu K D, Zhang H. 2023. Persulfidation of transcription factor MYB10 inhibits anthocyanin synthesis in red-skinned pear. Plant Physiology, 192, 2185–2202.
Yin X J, Wang T T, Zhang M, Zhang Y B, Irfan M, Chen L J, Zhang L. 2021. Role of core structural genes for flavonoid biosynthesis and transcriptional factors in flower color of plants. Biotechnology & Biotechnological Equipment, 35, 1214–1229.
Zhai R, Zhao Y X, Wu M, Yang J, Li X Y, Liu H T, Wu T, Liang F F, Yang C Q, Wang Z G, Ma F W, Xu L F. 2019. The MYB transcription factor PbMYB12b positively regulates flavonol biosynthesis in pear fruit. BMC Plant Biology, 19, 85.
Zhang S H, Wang H, Wang T, Liu W J, Zhang J, Fang H C, Zhang Z Y, Peng F T, Chen X S, Wang N. 2023. MdMYB305-MdbHLH33-MdMYB10 regulates sugar and anthocyanin balance in red-fleshed apple fruits. The Plant Journal, 133, 1062–1079.
Zhang X Y, Huai J L, Shang F F, Xu G, Tang W J, Jing Y J, Lin R C. 2017. A PIF1/PIF3-HY5-BBX23 transcription factor cascade affects photomorphogenesis. Plant Physiology, 174, 2487–2500.
Zhang Y Z, Xu S Z, Cheng Y W, Wang J, Wang X X, Liu R X, Han J M. 2020. Functional identification of PsMYB57 involved in anthocyanin regulation of tree peony. BMC Genetics, 21, 124.
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