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| Creatine Pyruvate Enhances Lipolysis and Protein Synthesis in Broiler Chicken |
| CHEN Juan, MA Hai-tian, WANG Man, KONG Yi-li , ZOU Si-xiang |
| 1.Key Laboratory of Animal Physiology & Biochemistry, College of Veterinary Medicine, Nanjing Agricultural University, Nanjing 210095,P.R.China |
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摘要 To assess the effects of creatine pyruvate (Cr-Pyr) on lipid and protein metabolism in broiler chickens, a total of 400 1-day-old male birds (Aconred) were randomly allocated to four groups, with each group replicating four times and each replicate involving 25 birds. The broilers were provided with a commercial diet supplemented with Cr-Pyr at 0, 1, 5, or 10% of the diet, respectively, for a period of 3 wk ad libitum (from 22 to 42 d). In the present study, body weight (BW) and average daily gain (ADG) of broilers decreased in 10% Cr-Pyr group (P<0.01), whereas the relative leg and pectoral muscle weights were significantly higher than they were in the control group (P<0.05). 5 or 10% Cr-Pyr of diets decreased the abdominal fat rate (AFR, abdominal fat/live weight) of the broilers. The serum or hepatic triglyceride (TG) concentrations were significantly lower in the 5 and 10% groups (P<0.01). In contrast, Cr-Pyr caused a marked increase in the serum nonesterified fatty acid (NEFA), high-density lipoprotein cholesterol (HDL-C) and creatine kinase (CK) concentrations (P<0.01). Supplementation with Cr-Pyr (5 and 10%) in the diet also increased glucagons (GLU), insulin (INS) or leptin (LEP) contents (P<0.01). The expression of hepatic peroxisomal proliferators-activated receptor α (PPAR-α) and carnitine palmitoyl transferase-I (CPT-I), muscle insulin-like growth factor I (IGF-I) were significantly elevated and myostatin mRNA level was reduced in the 5 and 10% groups (P<0.05). It was found that supplementation with 5% Cr-Pyr improves both lipid and protein metabolism by regulating various metabolic parameters of broilers, while not adversely affects growth performance in broiler chickens.
Abstract To assess the effects of creatine pyruvate (Cr-Pyr) on lipid and protein metabolism in broiler chickens, a total of 400 1-day-old male birds (Aconred) were randomly allocated to four groups, with each group replicating four times and each replicate involving 25 birds. The broilers were provided with a commercial diet supplemented with Cr-Pyr at 0, 1, 5, or 10% of the diet, respectively, for a period of 3 wk ad libitum (from 22 to 42 d). In the present study, body weight (BW) and average daily gain (ADG) of broilers decreased in 10% Cr-Pyr group (P<0.01), whereas the relative leg and pectoral muscle weights were significantly higher than they were in the control group (P<0.05). 5 or 10% Cr-Pyr of diets decreased the abdominal fat rate (AFR, abdominal fat/live weight) of the broilers. The serum or hepatic triglyceride (TG) concentrations were significantly lower in the 5 and 10% groups (P<0.01). In contrast, Cr-Pyr caused a marked increase in the serum nonesterified fatty acid (NEFA), high-density lipoprotein cholesterol (HDL-C) and creatine kinase (CK) concentrations (P<0.01). Supplementation with Cr-Pyr (5 and 10%) in the diet also increased glucagons (GLU), insulin (INS) or leptin (LEP) contents (P<0.01). The expression of hepatic peroxisomal proliferators-activated receptor α (PPAR-α) and carnitine palmitoyl transferase-I (CPT-I), muscle insulin-like growth factor I (IGF-I) were significantly elevated and myostatin mRNA level was reduced in the 5 and 10% groups (P<0.05). It was found that supplementation with 5% Cr-Pyr improves both lipid and protein metabolism by regulating various metabolic parameters of broilers, while not adversely affects growth performance in broiler chickens.
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Received: 16 November 2010
Accepted:
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| Fund: This research was supported by the the National Natural Science Foundation of China (30600439). |
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Corresponding Authors:
Correspondence ZOU Si-xiang, Tel: +86-25-84396763, Fax: +86-25-84398669, E-mail:sixiangzou@njau.edu.cn
E-mail: sixiangzou@njau.edu.cn
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| About author: CHEN Juan, Mobile: 13221008997, E-mail: 2008207014@njau.edu.cn |
Cite this article:
CHEN Juan, MA Hai-tian, WANG Man, KONG Yi-li , ZOU Si-xiang.
2011.
Creatine Pyruvate Enhances Lipolysis and Protein Synthesis in Broiler Chicken. Journal of Integrative Agriculture, 10(12): 1977-1985.
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