【Objective】 The effects of hot air-vacuum freeze combined with drying (HA-VFCD) on the physical properties and prebiotic activities of high-quality brittle dried longan were investigated in the present study, so as to provide a theoretical basis for the optimal industrialized energy-saving drying mode. 【Method】 In present study, the effect of HA-VFCD on the physicochemical and nutritional characteristics, such as moisture content, water activity, shrinkage rate, water rehydration ratio, total sugar and polysaccharide contents of brittle dried longan, were compared with that of individual hot air drying (HAD) and vacuum freeze drying (VFD) longan samples. The flavor substance changes and the energy consumption were also evaluated by GC-MS and ammeter, respectively. Furthermore, the dried longan was fermented by Lactobacillus plantarum and Lactobacillus acidophilus to investigate the content changes of viable bacteria, total sugar, reducing sugar and short-chain fatty acid, thus evaluating the effect of HA-VFCD on the in vitro prebiotic activities of longan. 【Result】 Longan dried by HA-VFCD showed significantly lower moisture content, water activity and shrinkage rate, but higher rehydration ratio, compared with the HAD counterparts. The content of total sugar, polysaccharide, and the types and amounts of volatile flavor of longan dried by HA-VFCD were lower than those of VFD samples, but higher than that of HAD counterparts. In addition, HA-VFCD process could save 12.16% of drying time and 25.40% of unit energy consumption, compared with VFD process. Both Lactobacillus plantarum and Lactobacillus acidophilus could increase the number of viable bacteria through fermentation of dried longan, which were used the total sugar in dried longan to produce short-chain fatty acids and to reduce the pH of fermentation broth. And the prebiotic activities of dried longan after fermentation were remarkably affected by the drying methods and the strain types of bacteria. After fermentation by the Lactobacillus plantarumfor 48 hours, the viable bacteria number of longan dried by HA-VFCD achieved the highest value of 12.40 lg cfu/mL, which was higher than that of HAD, VFD and fresh longan samples. After fermentation by the Lactobacillus acidophilus for 48 hours, the viable bacteria number of longan dried by HA-VFCD reached 11.84 lg cfu/mL, which was close to that of VFD samples, lower than HAD samples but higher than that of fresh longan. 【Conclusion】 The HA-VFCD process combined both the advantages of HAD and VFD, which could remarkably shorten the drying time, lower the energy consumption, and improve the drying efficiency and quality of dried longan.