果品主要真菌毒素污染检测、风险评估与控制研究进展

doi:10.3864/j.issn.0578-1752.2017.02.012

Abstract

Abstract: Fungi are major pathogens to fruit spoilage in the production, storage and transportation, and also are responsible for significant financial losses. In addition to their ability to cause fruit spoilage, some fungi may produce mycotoxins with potential harm to human health. Mycotoxins are a diverse group of toxic secondary metabolites produced by filamentous fungi under appropriate conditions. Followed by pesticide and heavy metal, the mycotoxins are considered as another important risk factor which can directly affect the quality and safety of fruits and fruit products. Numerous studies show that the mycotoxins can cause DNA damage and are harmful to human and animal health even at low concentrations. They caused liver, kidneys and gastrointestinal tract lesions or may be carcinogenic, teratogenic and mutagenic. Therefore, it is important to investigate the occurrence, accurate detection, risk assessment and control technology of mycotoxins in fruit and fruit products. The most common mycotoxins associated with fruits are patulin (PAT), aflatoxins (AF), alternaria toxins and ochratoxin A (OTA) which are respectively classified into 3, 1, 2B and 2B carcinogen by the International Agency for Research on Cancer (IARC). Usually, equipments with high standard configurations are needed for mycotoxin detection due to the extremely low concentrations in fruits and their products. Currently the main detection methods for mycotoxins include thin-layer chromatography, high performance liquid chromatography and mass spectrometry, gas chromatography and mass spectrometry, capillary electrophoresis technology, and so on. However, because of the different chemical structure and properties of special mycotoxin, it is incapable to use a standard method for the simultaneous quantitative determination of all mycotoxins. Therefore, it is a research hotspot to screen accurate, efficient and rapid detection methods for mycotoxins. To date, a total of 80 countries and regions have set the mycotoxin limits in fruits and fruit products to protect the health of consumers. It is to be regretted that there were no regulations for Alternaria toxins yet. Risk assessment results based on toxicological data in many countries were shown that dietary intakes of the mycotoxins from fruits and their products were very low in most cases and may not threaten the human health. Although the mycotoxins in fruits and their products could be prevented and degraded by chemical, physical or biological methods, there has not been an effective technology to complete detoxification in infected products. Hence, it is crucial to prevent mycotoxin production in fruits rather than remove. This review summarized the main mycotoxin types, occurrence, toxicities, detection methods, limit standards, risk assessments and control technologies in fruit and fruit products. And finally, the future research directions of fruit mycotoxins were prospected in order to provide a reference for researchers in this field.

Key words: fruit and fruit products, mycotoxin; patulin, aflatoxin, alternaria toxin, ochratoxin A, risk assessment

LI ZhiXia, NIE JiYun, YAN Zhen, ZHANG XiaoNan, GUAN DiKai, SHEN YouMing, CHENG Yang. Progress in Research of Detection, Risk Assessment and Control of the Mycotoxins in Fruits and Fruit Products[J].Scientia Agricultura Sinica, 2017, 50(2): 332-347.

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References

[1] Food and Agriculture Organization of the United Nations (FAO). [2017-1-6]. Production Crop[EB/OL]. http://www.fao.org/faostat/en/ #data/QC

[2] 李培武, 张奇, 丁小霞, 白艺珍. 食用植物性农产品质量安全研究进展. 中国农业科学, 2014, 47(18): 3618-3632.

LI P W, ZHANG Q, DING X X, BAI Y Z. A review of studies on quality and safety of edible vegetable agro-products. Scientia Agricultura Sinica, 2014, 47(18): 3618-3632. (in Chinese)

[3] YANG J Y, LI J, JIANG Y M, DUAN X W, QU H X, YANG B, CHEN F, SIVAKUMAR D. Natural occurrence, analysis, and prevention of mycotoxins in fruits and their processed products. Critical Reviews in Food Science and Nutrition, 2014, 54: 64-83.

[4] BHAT R, SRIDHAR K R, KARIM A A. Microbial quality evaluation and effective decontamination of nutraceutically valued lotus seeds by electron beams and gamma irradiation. Radiation Physics and Chemistry, 2010, 79: 976-981.

[5] FERNÁNDEZ-CRUZ M L, MANSILLA M L, TADEO J L. Mycotoxins in fruits and their processed products: Analysis, occurrence and health implications. Journal of Advanced Research, 2010, 1: 113-122.

[6] BARKAI-GOLAN R, PASTER N. Mycotoxins in Fruits and Vegetables. New York: Academic Press, 2008.

[7] FUNG F, CLARK R F. Health effects of mycotoxins: A toxicological overview. Journal of Toxicology. Clinical Toxicology, 2004, 42(2): 217-234.

[8] SHEPHARD G S. Impact of mycotoxins on human health in developing countries. Food Additives and Contaminants: Part A, 2008, 25(2): 146-151.

[9] ZAIN M E. Impact of mycotoxins on humans and animals. Journal of Saudi Chemical Society, 2011, 15: 129-144.

[10] MEDINA Á, MATEO R, VALLE-ALGARRA F M, MATEO E M, JIMÉNEZ M. Effect of carbendazim and physicochemical factors on the growth and ochratoxin A production of Aspergillus carbonarius isolated from grapes. International Journal of Food Microbiology, 2007, 119(3): 230-235.

[11] TRUCKSESS M W, SCOTT P M. Mycotoxins in botanicals and dried fruits: A review. Food Additives and Contaminants: Part A, 2008, 25(2): 181-192.

[12] GNONLONFIN G J B, ADJOVI Y C, TOKPO A F, AGBEKPONOU E D, AMEYAPOH Y, DE SOUZA C, BRIMER L, SANNI A. Mycobiota and identification of aflatoxin gene cluster in marketed spices in West Africa. Food Control, 2013, 34: 115-120.

[13] VACLAVIKOVA M, DZUMAN Z, LACINA O, FENCLOVA M, VEPRIKOVA Z, ZACHARIASOVA M, HAJSLOVA J. Monitoring survey of patulin in a variety of fruit-based products using a sensitive UHPLC-MS/MS analytical procedure. Food Control, 2015, 47: 577-584.

[14] NTASIOU P, MYRESIOTIS C, KONSTANTINOU S, PAPADOPOULOU-MOURKIDOU E, KARAOGLANIDIS G S. Identification, characterization and mycotoxigenic ability of Alternaria spp. causing core rot of apple fruit in Greece. International Journal of Food Microbiology, 2015, 197: 22-29.

[15] WANG M, JIANG N, XIAN H, WEI D Z, SHI L, FENG X Y. A single-step solid phase extraction for the simultaneous determination of 8 mycotoxins in fruits by ultra-high performance liquid chromatography tandem mass spectrometry. Journal of Chromatography A, 2016, 1429: 22-29.

[16] 王督, 张文, 李培武, 张奇, 张兆威, 丁小霞, 姜俊. 胶体金免疫层析法快速定量分析粮油农产品中黄曲霉毒素B₁. 中国油料作物学报, 2014, 36(4): 529-532.

WANG D, ZHANG W, LI P W, ZHANG Q, ZHANG Z W, DING X X, JIANG J. Rapid and quantitative detection of aflatoxin B₁ in plant grain and oilseeds products using colloid golden immuno- chromatographic method. Chinese Journal of Oil Crop Sciences, 2014, 36(4): 529-532. (in Chinese)

[17] 孙娟, 李为喜, 张妍, 孙丽娟, 董晓丽, 胡学旭, 王步军. 用超高效液相色谱串联质谱法同时测定谷物中12种真菌毒素. 作物学报, 2014, 40(4): 691-701.

SUN J, Li W X, Zhang Y, Sun L J, Dong X L, Hu X X, Wang B J. Simultaneous determination of twelve mycotoxins in cereals by Ultra-high performance liquid chromatography-tendem mass spectrometry. Acta Agronomica Sinica, 2014, 40(4): 691-701. (in Chinese)

[18] 王战辉, 米铁军, 沈建忠. 荧光偏振免疫分析检测粮食及其制品中的真菌毒素研究进展. 中国农业科学, 2012, 45(23): 4862-4872.

Wang Z H, Mi T J, Shen J Z. Advance in fluorescence polarization immunoassay for the determination of mycotoxins in cereals and related products. Scientia Agricultura Sinica, 2012, 45(23): 4862-4872. (in Chinese)

[19] 张小平, 李元瑞, 师俊玲, 岳田利. 苹果汁中棒曲霉素控制技术研究进展. 中国农业科学, 2004, 37(11): 1672-1676.

Zhang X P, Li Y R, Shi J L, Yue T L. A Review on the Control of Patulin in Apple Juice. Scientia Agricultura Sinica, 2004, 37(11): 1672-1676. (in Chinese)

[20] 李卫华, 杜利君, 宋欢. 高效液相色谱法测定浓缩苹果汁中棒曲霉毒素. 食品科学, 2007, 28(08): 408- 410.

Li W H, Du L J, Song H. Determination of patulin in apple juice concentrated by high performance liquid chromatography. Food Science, 2007, 28(08): 408- 410. (in Chinese)

[21] 何强, 李建华, 孔祥虹, 乐爱山, 吴双民. 超高效液相色谱-串联质谱法同时测定浓缩苹果汁中的4种链格孢霉毒素. 色谱, 2010, 28(12): 1128-1131.

He Q, Li J H, Kong X H, Yue A S, Wu S M. Simultaneous determ ination of fourAlternariatoxins in apple juice concentrate by ultra performance liquid chromatography-electrospray ionization tandem mass spectrometry. Chinese Journal of Chromatography, 2010, 28(12): 1128-1131. (in Chinese)

[22] 侯建波, 谢文, 李杰, 沈炜锋, 何建敏. 液相色谱-串联质谱法测定葡萄酒中赭曲霉毒素A. 中国酿造, 2014, 33(5): 146-149.

HOU J B, XIE W, LI J, SHEN W F, HE J M. Determination of ochratoxin A in wine by LC-MS/MS. China Brewing, 2014, 33(5): 146-149. (in Chinese)

[23] Paster N, Barkai-Golan R. Mouldy fruits and vegetables as a source of mycotoxins: part 2. World Mycotoxin Journal, 2008, 4: 385-396.

[24] Ostry V, Skarkova J, Ruprich J. Occurrence of Penicillium expansum and patulin in apples as raw materials for processing of foods-case study. Mycotoxin Research, 2004, 20(1): 24-28.

[25] Soliman S, Li X Z, Shao S, Behar M, Svircev A M, Tsao R, Zhou T. Potential mycotoxin contamination risks of apple products associated with fungal flora of apple core. Food Control, 2015, 47: 585-591.

[26] Frizzell C, Elliott C T, Connolly L. Effects of the mycotoxin patulin at the level of nuclear receptor transcriptional activity and steroidogenesis in vitro. Toxicology Letters, 2014, 229: 366-373.

[27] Sarubbi F, Formisano G, Auriemma G, Arrichiello A, Palomba R. Patulin in homogenized fruit's and tomato products. Food Control, 2016, 59: 420-423.

[28] Moake M, Padilla-Zakour O, Worobo R W. Comprehensive review of patulin control methods in foods. Comprehensive Reviews in Food Science and Food Safety, 2005, 4(1): 8-21.

[29] Puel O, Galtier P, Oswald I P. Biosynthesis and toxicological effects of patulin. Toxins, 2010, 2(4): 613-631.

[30] Piqué E, Vargas-Murga L, Gómez-Catalán J, Lapuente J, Llobet J M. Occurrence of patulin in organic and conventional apple-based food marketed in Catalonia and exposure assessment. Food and Chemical Toxicology, 2013, 60: 199-204.

[31] Zhou S M, Jiang L P, Geng C Y, Cao J, Zhong L F. Patulin induced oxidative DNA damage and p53 modulation in HepG2 cells. Toxicon, 2010, 55: 390-395.

[32] Asao T, Büchi G, Abdel K M M, Chang S B, Wick E L, Wogan G N. Structures of aflatoxins B and G₁. Journal of the American Chemical Society, 1965, 87(4): 882-886.

[33] Juan C, Zinedine A , J C Moltó, Idrissi L, Mañes J. Aflatoxins levels in dried fruits and nuts from Rabat-Salé area, Morocco. Food Control, 2008, 19: 849-853.

[34] Iqbal S Z, Asi M R, Jinap S. Aflatoxins in dates and dates products. Food Control, 2014, 43: 163-166.

[35] Bamba R, Sumbali G. Co-occurrence of aflatoxin B₁ and cyclopiazonic acid in sour lime (Citrus aurantifolia Swingle) during post-harvest pathogenesis by Aspergillus flavus. Mycopathologia, 2005, 159: 407-411.

[36] International Agency for Research on Cancer (IARC). IARC Monographs on the Evaluation of Carcinogenic Risks to Humans, Some Naturally Occurring Substances, Food Items and Constituents, Heterocyclic Aromatic Amines and Mycotoxins. Lyon, France: IARC, 1993: 56.

[37] International Agency for Research on Cancer (IARC). IARC Monographs on the Evaluation of Carcinogenic Risks to Humans. Lyon, France: IARC, 2002: 82.

[38] Stark A A. Mechanisms of action of aflatoxin B₁ at the biochemical and molecular levels In Microbial Food Contamination (C.L. Wilson and S. Droby, eds). Boca Raton, FL: CRC Press, 2001.

[39] Li P W, Zhang Q, Zhang W. Immunoassays for aflatoxins. Trends in Analytical Chemistry, 2009, 28(9): 1115-1126.

[40] Andersen B, Kroger E, Roberts R G. Chemical and morphological segregation of Alternaria arborescens, A. infectoria and A. tenuissima species-groups. Mycological Research, 2002, 106: 170-182.

[41] Perre E V, Deschuyffeleer N, Jacxsens L, Vekeman F, Hauwaert W V D, Asam S, Rychlik M, Devlieghere F, Meulenaer B D. Screening of moulds and mycotoxins in tomatoes, bell peppers, onions, soft red fruits and derived tomato products. Food Control, 2014, 37: 165-170.

[42] Greco M, Patriarca A, Terminiello L, Pinto V F, Pose G. Toxigenic Alternaria species from Argentinean blueberries. International Journal of Food Microbiology, 2012, 154: 187-191.

[43] Andersen B, J Smedsgaard, Jørring I, Skouboe P, Pedersen L H. Real-time PCR quantification of the AM-toxin gene and HPLC qualification of toxigenic metabolites from Alternaria species from apples. International Journal of Food Microbiology, 2006, 111: 105-111.

[44] Logrieco A, Bottalico A, Mule G, Moretti A, Perrone G. Epidemiology of toxigenic fungi and their associated mycotoxins for some Mediterranean crops. European Journal of Plant Pathology, 2003, 109: 645-667.

[45] Visconti A, Logrieco A, Bottalico A. Natural occurrence of Alternaria mycotoxins in olives: Production and possible transfer into oil. Food Additives and Contaminants, 1986, 4: 323-330.

[46] López P, Venema D, de Rijk T, de Kok A, Scholten J M, Mol H G J, de Nijs M. Occurrence of Alternaria toxins in food products in the Netherlands. Food Control, 2016, 60: 196-204.

[47] Scott P, Lawrence B, Lau B. Analysis of wines, grape juices and cranberry juices for Alternaria toxins. Mycotoxin Research, 2006, 22: 142-147.

[48] Prelle A, Spadaro D, Garibaldi A, Gullino M L. A new method for detection of five alternaria toxins in food matrices based on LC-APCI-MS. Food Chemistry, 2013, 140: 161-167.

[49] Panigrahi S, Dallin S. Toxicity of the Alternaria spp metabolites, tenuazonic acid, alternariol, altertoxin-I, and alternariol monomethyl ether to brine shrimp (Artemia salina L) larvae. Journal of the Science of Food and Agriculture, 1994, 66(4): 493-496.

[50] Liu G T, Qian Y Z, Zhang P, Dong W H, Qi Y M, Guo H T. Etiologic role of alternaria-alternata in human esophageal cancer. Chinese Medical Journal Peking, 1992, 105: 394-400.

[51] Zhou B, Qiang S. Environmental, genetic and cellular toxicity of tenuazonic acid isolated from Alternaria alternata. African Journal of Biotechnology, 2008, 7: 1151-1156.

[52] Ostry V. Alternaria mycotoxins: an overview of chemical characterization, producers, toxicity, analysis and occurrence in foodstuffs. World Mycotoxin Journal, 2008, 1: 175-188.

[53] Battilani P, Pietri A. Ochratoxin A in grape and wine. European Journal of Plant Pathology. 2002,108: 639-643.

[54] Jiang C M, Shi J L, Zhu C Y. Fruit spoilage and ochratoxin a production by Aspergillus carbonarius in the berries of different grape cultivars. Food Control, 2013, 30: 93-100.

[55] Chulze S N, Magnoli C E, Dalcero A M. Occurrence of ochratoxin A in wine and ochratoxigenic mycoflora in grapes and dried vine fruits in South America. International Journal of Food Microbiology, 2006, 111: S5-S9.

[56] Perre E V, Jacxsens L, Lachat C, Tahan F E, Meulenaer B. Impact of maximum levels in European legislation on exposure of mycotoxins in dried products: Case of aflatoxin B₁ and ochratoxin A in nuts and dried fruits. Food and Chemical Toxicology, 2015, 75: 112-117.

[57] Engelhardt G, Ruhland M, Wallnöfer P R. Occurrence of ochratoxin A in moldy vegetables and fruits analysed after removal of rotten tissue parts. Advances in food sciences, 1999, 21(3-4): 88-92.

[58] Andreana Marino, Antonia Nostro, Caterina Fiorentino. Ochratoxin A production by Aspergillus westerdijkiae in orange fruit and juice. International Journal of Food Microbiology, 2009, 132: 185-189.

[59] Clark H A, Snedeker S M. Ochratoxin A: its cancer risk and potential for exposure. Journal of Toxicology and Environmental Health, Part B, 2006, 9(3): 265-296.

[60] Stoev S D. Foodborne mycotoxicoses, risk assessment and underestimated hazard of masked mycotoxins and joint mycotoxin effects or interaction. Environmental Toxicology and Pharmacology, 2015, 39(2): 794-809.

[61] European Food Safety Authority (EFSA). Opinion of the Scientific Panel on Contaminants in the Food Chain Related. Statement on Recent Scientific Information on the Toxicity of Ochratoxin A. Parma, Italy. 2010.

[62] Leszkowiezy A P, BoeharovaT P, Chemozemsky I N, Castegnaro M. Balkan endemic nephropathy and associated urinary tract tumours: A review on aetiological causes and the potential role of myeotoxins. Food Additives and Contaminants: Part A, 2002, 19(3): 282-302.

[63] Rucevic M, Rosenquist T, Breen L, Cao L L, Clifton J, Hixson D, JOSIC D. Proteome alterations in response to aristolochic acids in experimental animal model. Journal of Proteomics, 2012, 76: 79-90.

[64] Turner N W, Subrahmanyam S, Piletsky S A. Analytical methods for determination of mycotoxins: A review. Analytica Chimica Acta, 2009, 632(2): 168-180.

[65] Welke J E, Hoeltz M, Dottori H A, Noll I B. Quantitative analysis of patulin in apple juice by thin-layer chromatography using a charge coupled device detector. Food Additives and Contaminants: Part A, 2009, 26(5): 754-758.

[66] Elhariry H, Bahobial A A, Gherbawy Y. Genotypic identification of Penicillium expansum and the role of processing on patulin presence in juice. Food and Chemical Toxicology, 2011, 49(4): 941-946.

[67] Santos E A, Vargas E A. Immunoaffinity column clean-up and thin layer chromatography for determination of ochratoxin A in green coffee. Food Additives and Contaminants, 2002, 19(5): 447-458.

[68] Myresiotis C K, Testempasis S, Vryzas Z, Karaoglanidis G S, Papadopoulou-Mourkidou E. Determination of mycotoxins in pomegranate fruits and juices using a QuEChERS-based method. Food Chemistry, 2015, 182: 81-88.

[69] Sulyok M, Krska R, Schuhmacher R. Application of an LC-MS/MS based multi-mycotoxin method for the semi-quantitative determination of mycotoxins occurring in different types of food infected by moulds. Food Chemistry, 2010, 119: 408-416.

[70] Zwickel T, Klaffke H, Richards K, Rychlik M. Development of a high performance liquid chromatography tandem mass spectrometry based analysis for the simultaneous quantification of various Alternaria toxins in wine, vegetable juices and fruit juices. Journal of Chromatography A, 2016, http://dx.doi.org/doi:10.1016/ j.chroma.2016.04.066.

[71] 史文景, 赵其阳, 焦必宁. UPLC-ESI-MS-MS结合QuEChERS同时测定柑橘中的4种真菌毒素. 食品科学, 2014, 35(20): 170-174.

Shi W J, Zhao Q Y, Jiao B N. Simultaneous determination of four mycotoxins in citrus fruits by ultra performance liquid chromatography- electrospray ionization tandem mass spectrometry combined with modified QuEChERS. Food Science, 2014, 35(20): 170-174. (in Chinese)

[72] Kharandi N, Babri M, Azad J. A novel method for determination of patulin in apple juices by GC–MS. Food Chemistry, 2013, 141(3): 1619-1623.

[73] Jiménez M, Mateo R. Determination of mycotoxins produced by Fusarium isolates from banana fruits by capillary gas chromatography and high-performance liquid chromatography. Journal of Chromatography A, 1997, 778: 363-372.

[74] Murillo-Arbizu M, González-Peñas E, Hansen S H, Amézqueta S, Østergaard J. Development and validation of a microemulsion electrokinetic chromatography method for patulin quantification in commercial apple juice. Food and Chemical Toxicology, 2008, 46(6): 2251-2257.

[75] Murillo-Arbizu M, González-Peñas E, Amézqueta S. Determination of patulin in commercial apple juice by micellar electrokinetic chromatography. Food and Chemical Toxicology, 2008, 46(1): 57-64.

[76] González-Peñas E, Leache C, Cerain A L, Lizarraga E. Comparison between capillary electrophoresis and HPLC-FL for ochratoxin A quantification in wine. Food Chemistry, 2006, 97(2): 349-354.

[77] Luque M I, Córdoba J J, Rodríguez A, Núñez F, Andrade M J. Development of a PCR protocol to detect ochratoxin A producing moulds in food products. Food Control, 2013, 29(1): 270-278.

[78] Schuller P L, Van Egmond H P, Stoloff L. Limits and regulations on mycotoxins In Proceedings of the International Symposium on Mycotoxins, 6-8 September 1981 (NaguibK, Naguib M M, Park D L, Pohland A E. eds). Cairo, Egypt: General Organization for Government Printing Offices, 1983.

[79] van Egmond H. Current situation on regulations for mycotoxins. Overview of tolerances and status of standard methods of sampling and analysis. Food Additives and Contaminants, 1989, 6: 139-188.

[80] Food and Agriculture Organization (FAO). Worldwide regulations for mycotoxins in food and feed in 1995. A Compendium. FAO Food and Nutrition Paper, 64, Food and Agriculture Organization of the United Nations, Rome, Italy. 1997.

[81] Food and Agriculture Organization (FAO). Worldwide regulations for mycotoxins in food and feed in 2003. FAO Food and Nutrition Paper, 81, Food and Agriculture Organization of the United Nations, Rome, Italy. 2004.

[82] 中华人民共和国卫生部. 食品安全国家标准: 食品中真菌毒素限量（GB 2761—2011）. 北京: 中国标准出版社, 2011.

Ministry of Health, People’s Republic of China. National food safety standard: Limits for mycotoxins in food (GB 2761—2011). Beijing: Standards Press of China, 2011. (in Chinese)

[83] Anukul N, Vangnai K, Mahakarnchanakul W. Significance of regulation limits in mycotoxin contamination in Asia and risk management programs at the national level. Journal of Food and Drug Analysis, 2013, 21(3): 227-241.

[84] Sirot V, Fremy J-M, Leblanc J-C. Dietary exposure to mycotoxins and health risk assessment in the second French total diet study. Food and Chemical Toxicology, 2013, 5: 1-11.

[85] Han Z, Nie D X, Yang X L, Wang J H, Peng S J, Wu A B. Quantitative assessment of risk associated with dietary intake of mycotoxin ochratoxin A on the adult inhabitants in Shanghai city of P.R. China. Food Control, 2013, 32: 490-495.

[86] Raad F, Nasreddine L, Hilan C, Bartosik M, Parent-Massin D. Dietary exposure to aflatoxins, ochratoxin A and deoxynivalenol from a total diet study in an adult urban Lebanese population. Food and Chemical Toxicology, 2014, 73: 35-43.

[87] Serrano A B, Font G, Ruiz M J, Ferrer E. Co-occurrence and risk assessment of mycotoxins in food and diet from Mediterranean area. Food Chemistry, 2012, 135(2): 423-429.

[88] Cano-Sancho G, Marin S, Ramos A J, Sanchis V. Occurrence of zearalenone, an oestrogenic mycotoxin, in Catalonia (Spain) and exposure assessment. Food and Chemical Toxicology, 2012, 50: 835-839.

[89] Guo Y D, Zhou Z K, Yuan Y H, Yue T L. Survey of patulin in apple juice concentrates in Shaanxi (China) and its dietary intake. Food Control, 2013, 34: 570-573.

[90] Piemontese L, Solfrizzo M, Visconti A. Occurrence of patulin in conventional and organic fruit products in Italy and subsequent exposure assessment. Food Additives and Contaminants, 2005, 22: 437-442.

[91] Azaiez I, Font G, Mañes J, Fernández-Franzón M. Survey of mycotoxins in dates and dried fruits from Tunisian and Spanish markets. Food Control, 2015, 51: 340-346.

[92] The Scientific Committee for Food European Commission (SCF). [2016-4-16]. Assessment of dietary intake of Ochratoxin A by the population of EU Member States. [EB/OL]. http://ec.europa.eu/food/ fs/scoop/3.2.7_en.pdf.

[93] Kuiper-Goodman T. Food safety: mycotoxins and phycotoxins in perspective. In: Miraglia M, van Egmond H P, Brera C, Gilbert J (Eds.), Mycotoxins and Phycotoxins: Developments in Chemistry, Toxicology and Food Safety. Alakens, Fort Collins, 1998.

[94] World Health Organization (WHO). Evaluation of certain food additives and contaminants. 44th Report of the Joint Food and Agriculture Organization/World Health Organization Expert Committee on Food Additives, In: Technical Report Series 859. WHO, Geneva, Switzerland, 1995.

[95] Kuiper-Goodman T, Hilts C, Billiard S M, Kiparissis Y, Richard I D K, Hayward S. Health risk assessment of ochratoxin A for all age-sex strata in a market economy. Food Additives & Contaminants: Part A, 2010, 27(2): 212-240.

[96] European Food Safety Authority (EFSA). Opinion of the scientific panel on contaminants in the food chain[CONTAM] related to the potential increase of consumer health risk by a possible increase of the existing maximum levels for aflatoxins in almonds, hazelnuts and pistachios and derived products. EFSA, Parma, Intaly. Doi: 10-2903/ j.efsa. 2007.446.

[97] Malmauret L, Parent-Massin D, Hardy J L, Verger P. Contaminants in organic and conventional foodstuffs in France. Food Additives and Contaminants, 2002, 19: 524-532.

[98] Beretta B, Gaiaschi A, Galli C L, Restani P. Patulin in apple-based foods: occurrence and safety evaluation. Food Additives and Contaminants, 2000, 17: 399-406.

[99] Baert K, Kasase C, De Meulenaer B, Huyghebaert A. Incidence of patulin in organic and conventional apple juices marketed in Belgium//First International Symposium on Recent Advances in Food Analysis, Prague, Czech Republic, 2013.

[100] Neri F, Mari M, Menniti AM, Brigati S. Activity of trans-2-hexenal against Penicillium expansum in ‘Conference’ pears. Journal of Applied Microbiology, 2006, 100: 1186-1193.

[101] Gemeda N, Woldeamanuel Y, Asrat D, Debella A. Effect of essential oils on Aspergillus spore germination, growth and mycotoxin production: a potential source of botanical food preservative. Asian Pacific Journal of Tropical Biomedicine, 2014, 4: S373-S381.

[102]金发忠. 基于我国农产品客观特性的质量安全问题思考. 农产品质量与安全, 2015(3): 3-11.

Jin F Z. Consideration on the quality and safety of agricultural products in China based on their objective characteristics. Quality and Safety of Agro-products, 2015(3): 3-11. (in Chinese)

[103] Aziz N H, Moussa L A A. Influence of gamma-radiation on mycotoxin producing moulds and mycotoxins in fruits. Food Control, 2002, 13(4/5): 281-288.

[104]迟蕾, 哈益明, 王锋. γ射线对赭曲霉毒素A的辐照降解与产物分析. 食品科学, 2010, 31(11): 320-324.

Chi L, Ha Y M, Wang F. Degradation and product analysis of ochratoxin A induced by γ-irradiation. Food Science, 2010, 31(11): 320-324. (in Chinese)

[105] Liu J, Sui Y, Wisniewski M, Droby S, Liu Y S. Review: Utilization of antagonistic yeasts to manage postharvest fungal diseases of fruit. International Journal of Food Microbiology, 2013, 167(2): 153-160.

[106] Spadaro D, Lorè A, Garibaldi A, Gullino M L. A new strain of Metschnikowia fructicola for postharvest control of Penicillium expansum and patulin accumulation on four cultivars of apple. Postharvest Biology and Technology, 2013, 75: 1-8.

[107] Ahmed H, Strub C, Hilaire F, Schorr-Galindo S. First report: Penicillium adametzioides, a potential biocontrol agent for ochratoxin-producing fungus in grapes, resulting from natural product pre-harvest treatment. Food Control, 2015, 51: 23-30.

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Progress in Research of Detection, Risk Assessment and Control of the Mycotoxins in Fruits and Fruit Products

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