Scientia Agricultura Sinica ›› 2013, Vol. 46 ›› Issue (12): 2534-2542.doi: 10.3864/j.issn.0578-1752.2013.12.014

• STORAGE·FRESH-KEEPING·PROCESSING • Previous Articles     Next Articles

Advance in Research on Risk Assessment of Aflatoxin in Agricultural Products

 LI  Pei-Wu, DING  Xiao-Xia, BAI  Yi-Zhen, ZHOU  Hai-Yan, YIN  南Ri   

  1. 1.Oil Crops Research Institute of the Chinese Academy of Agricultural Sciences, Wuhan 430062
    2.Laboratory of Risk Assessment for Oilseeds Products(Wuhan), Ministry of Agriculture, Wuhan 430062
    3.Key Laboratory of Biology and Genetic Improvement of Oil Crops, Ministry of Agriculture, Wuhan 430062
    4.Key Laboratory of Detection for Mycotoxins, Ministry of Agriculture, Wuhan 430062
    5.Quality Inspection and Test Center for Oilseeds Products, Wuhan 430062
  • Received:2013-01-07 Online:2013-06-15 Published:2013-05-06

PDF

1279

Cited

15

Abstract: Aflatoxins are genotoxic and carcinogenic. For their serious impact on quality and safety and international trade of China’s agricultural products, especially on peanut and severe threat to both animal and human health, aflatoxins has been subjected to the extensive concern of the society. Domestic and foreign risk assessment researches of aflatoxins were comprehensively reviewed, and development of risk assessment of aflatoxin, technical difficulties and future trends were proposed for promoting the further development of risk assessment work of aflatoxins in China in the future.

Key words: quality and safety of agricultural products , food safety , aflatoxin , risk assessment

[1]International Agency for Research on Cancer. Some naturally occurring substances: food items and constituents, heterocyclic aromatic amines and mycotoxins. IARC Monographs on the Evaluation of Carcinogenic Risks to Humans, 1993, 56: 245-395.

[2]Torres-Pacheco I. Aflatoxin –Dectection, Measurement and Control. Croatia:  InTech, 2011.

[3]Williams J H, Phillips T D, Jolly C M, Aggarwal D. Human aflatoxin in developing countries: a review of toxicology, exposure, potential health consequences, and interventions. American Society and Clinical Nutrition, 2004, 80(5):1106-1122.

[4]International Agency for Research on Cancer. Some traditional herbal medicines, some mycotoxins, naphthalene, and styrene. IARC Monographs on the Evaluation of Carcinogenic Risks to Humans, 2002, 82: 1-556.

[5]Krishnamachari K A V R, Nagarajan V, Bhat R V, Tilak T B G. Hepatitis due to aflatoxicosis: an outbreak in western Indian, The Lancet, 1975, 305 (7915):1061-1063.

[6]Lye M S, Ghazali A A, Mohan J, Alwin N, Nair R C. An outbreak of acute hepatic encephalopathy due to severe aflatoxicosis in Malaysia. American Journal of Tropical Medicine and Hygiene, 1995, 53 (1): 68-72.

[7]Lewis L, Onsongo M, Njapau H, Schurz-Rogers H, Luber G, Kieszak S, Nyamongo J, Backer L, Dahiye A M, Misore A, DeCock K, Rubin C, the Kenya Aflatoxicosis Investigation Group. Aflatoxin contamination of commercial maize products during an outbreak of acute aflatoxicosis in eastern and central Kenya. Environmental Health Perspectives, 2005, 113(12): 1763-1767.

[8]Cullen J M, Newberne P M. Acute Hepatotoxicity of Aflatoxins. London: Academic Press, 1993.

[9]钱永忠，李耘. 农产品质量安全风险评估-原理、方法和应用.北京：中国标准出版,2007.

Qian Y Z, Li Y. Risk Assessment for Quality and Safety of Agro-foods Principles, Methodology and Applications. Beijing: China Standard Press, 2007. (in Chinese)

[10]International Agency for Research on Cancer. Some inorganic substances, chlorinated hydrocarbons, aromatic amines, N-nitroso compounds and natural products. IARC Monographs on the Evaluation of Carcinogenic Risks to Human, 1972, 1: 1-184.

[11]International Agency for Research on Cancer. Overall evaluations of carcinogenicity: an updating of IARC monographs volumes 1 to 42. IARC Monographs on the Evaluation of Carcinogenic Risks to Human, 1987(Suppl. 7): 1-440.

[12]Cullen J M, Ruebner B H, Hsieh L S, Hyde D M, Hsieh D P. Carcinogenicity of dietary aflatoxin M1 in male Fischer rats compared to aflatoxin B1.Cancer Research,1987, 47: 1913-1917.

[13]Joint FAO/WHO Expert Committee on Food Additives. Evaluation of certain food additives and contaminants. WHO Technical Report Series, 1987, 759: 359-469.

[14]Yeh F S, Yu M C, Mo C C, Luo S, Tong M J, Henderson B E. Hepatitis B virus, aflatoxins and hepatocellular carcinoma in Southern Guangxi China. Cancer Research, 1989, 49:2506-2509.

[15]McLean M, Dutton M F. Cellular interactions and metabolism of aflatoxin: an update.  Pharmacology and Therapeutics,1995, 65: 163-192. 

[16]Wild C P, Turner P C. Exposure biomarkers in chemoprevention studies of liver cancer. IARC Scientific Publications, 2001, 154: 215-222.

[17]Groopman J D, Wogan G N, Roebuck B D, Kensler T W. Molecular biomarkers for aflatoxins and their application to human cancer prevention. Cancer Research, 1994(Suppl.54): 1907-1911.

[18]International Agency for Research on Cancer. Application of Biomarkers in Cancer Epidemiology. Lyon: International Agency for Research on Cancer, 1997.

[19]Wild C P. Induction of specific cytochrome P450s involved in aflatoxin B1 metabolism in hepatitis B virus transgenic mice. Molecular Carcinogenesis, 1994, 11: 74-80.

[20]孙桂菊，钱耕荪，金锡鹏，陈建国，贺霞，王少康，蒋兆坤，王加生.肝癌高发地区人群黄曲霉毒素暴露水平的评估.东南大学学报: 医学版, 2002, 21(1): 118-122.

Sun G J, Qian G S, Jin X P, Chen J G, He X, Wang S K, Jiang Z K, Wang J S. Assessment of aflatoxin exposure in residents with high incidence of liver cancer. Journal of Southeast University: Medical Science Edition, 2002, 21(1):118-122. (in Chinese)

[21]Joint FAO/WHO Expert Committee on Food Additives. Evaluation of certain food additives and contaminants. WHO Technical Report Series, 1997, 868: 45-46.

[22]Joint FAO/WHO Expert Committee on Food Additives. Evaluation of certain food additives and contaminants. WHO Technical Report Series, 1999, 884: 45-46.

[23]Park J W, Kim E K, Kim Y B. Estimation of the daily exposure of Koreans to aflatoxin B1 through food consumption. Food Additives and Contaminants, 2004, 21(1): 70-75.

[24]Egal S, Hounsa A, Gong Y Y, Turner P C, Wild C P, Hall A J, Hell K, Cardwell K F. Dietary exposure to aflatoxin from maize and groundnut in young children from Benin and Togo, West Africa. International Journal of Food Microbiology, 2005, 104: 215-234.

[25]European Food Safety Authority. Opinion of the scientific panel on Contaminants in the food chain on a request from the Commission related to the potential increase of consumer health risk by a possible increase of the existing maximum levels for aflatoxins in almonds, hazelnuts and pistachios and derived products. The EFSA Journal, 2007, 446:1-127.

[26]Konishi Y S, Sato T, Saito S, Nakajima M, Tabata S, Tanaka T, Norizuki H, Itoh Y, Kai S, Sugiyama K, Kamata Y, Yoshiike N, Kumagai S. Exposure to aflatoxins in Japan: risk assessment for aflatoxin B1. Food Additives and Contaminants, 2010, 27(3): 365-372.

[27]Sun G, Wang S, Hu X, Su J, Zhang Y, Xie Y, Zhnag H, Tang L, Wang J S. Co-contamination of aflatoxin B1 and fumonisin B1 in food and human dietary exposure in three areas of China. Food Additives and Contaminants, 2011, 28(4): 461-470.

[28]Ding X X, Li P P, Bai Y Z, Zhou H Y. Aflatoxin B1 in post-harvest peanuts and dietary risk in China. Food Control, 2012, 23 (1): 143-148.

[29]Ghosh S K, Desai M R, Pandya G. L, Venkaiah K. Airborne aflatoxin in the grain processing industries in India. American Industrial Hygiene Association Journal, 1997, 58: 583-586.

[30]Kussak A, Andersson B, Andersson K. Determination of aflatoxins in airborne dust from feed factories by automated immunoaffinity column clean up and liquid chromatography. Journal of Chromatography A, 1995, 708 (1): 55-60.

[31]Kauppinen T, Toikkanen J, Pedersen D, Young R, Ahrens W, Boffetta P, Hansen J, Kromhout H, Blasco J M, Mirabelli D, Orden-Rivera V, Pannett B, Plato N, Savela A, Vincent R, Kogevinas M. Occupational exposure to carcinogens in the European Union. Occupational and Environmental Medicine, 2000, 57: 10-18.

[32]Selim M I, Juchems A M, Popendorf W. Assessing airborne aflatoxin B1 during on-farm grain handling activities. American Industrial Hygiene Association Journal, 1998, 59 (4): 252-256.

[33]Brera C, Caputi R, Miraglia M, Lavicoli L, Salerno A, Carelli G. Exposure assessment to mycotoxins in workplaces: aflatoxins and ochratoxin A occurrence in airborne dusts and human sera. Microchemical Journal, 2002, 73: 167-173.

[34]Liao C M, Chen S C. A probabilistic modeling approach to assess human inhalation exposure risks to airborne aflatoxin B1 (AFB1). Atmospheric Environment, 2005, 39: 6481-6490.

[35]Groopman J D, Kensler T W, Wild C P. Protective interventions to prevent aflatoxin-induced carcinogenesis in developing countries. Annual Review of Public Health, 2008, 29:187-203.

[36]Ross R K, Yuan J M,Yu M C, Wogan G N, Qian G S, Tu J T, Groopman J D, Gao Y T, Henderson B E. Urinary aflatoxin biomarkers and risk of hepatocellular carcinoma. The Lancet, 1992, 339(8799): 943-946.

[37]Qian G S, Ross R K, Yu M C, Yuan J M, Gao Y T, Henderson B E, Wogan G N, Groopman J D. A fellow study of urinary markers of aflatoxin exposure and liver cancer risk in Shanghai People’s Republic of China. Cancer Epidemiology Biomarkers and Prevention, 1994, 3:3-10.

[38]Wang L Y, Hatch M, Chen C J, Levin B, You S L, Lu S N, Wu M H, Wu W P, Wang L W, Wang Q, Huang G T, Yang P M., Lee H S, Santella R M. Aflatoxin exposure and risk of hepatocellular carcinoma in Taiwan. International Journal of Cancer, 1996, 67: 620-625.

[39]Wild C P, Hasegawa R, Barraud L, Chutimataewin S, Chapot B, Ito N, Montesano R. Aflatoxin-albumin adducts: a basis for comparative carcinogenesis between animals and humans. Cancer Epidemiology Biomarkers and Prevention, 1996, 5: 179-189.

[40]Poirier M C, Santella R M, Weston A. Carcinogen macromolecular adducts and their measurement. Carcinogenesis, 2000, 21:353-359.

[41]Su J J, Ban K C, Li Y, Qin L L, Wang H Y, Yang C, Ou C, Duan X X, Lee Y L, Yang R Q. Alteration of p53 and p21 during hepatocarcinogenesis in tree shrews. World Journal of Gastroenterology, 2004, 10 (24): 3559 -3563.

[42]Shephard G S. Risk assessment of aflatoxins in food in Africa. Food Additives and Contamination: Part A, 2008, 25 (10): 1246-1256.

[43]Ok H E, Kim H J, Shim W B, Lee H, Bae D H, Chung D H, Chun H  S. Natural occurrence of aflatoxin B1 in marketed foods and risk estimates of dietary exposure in Koreans. Journal of Food Protection, 2007, 70(12): 2824-2828.

[44]Leong Y H, Rosma A, Latiff A A, Ahmad N I. Exposure assessment and risk characterization of aflatoxin B1 in Malaysia. Mycotoxin Research, 2011, 27: 207-214.

[45]Joint FAO/WHO Expert Committee on Food Additives. Evaluation of certain food additives and contaminants. WHO Technical Report Series, 2007, 947: 159-168.

[46]王君，刘秀梅.中国人群黄曲霉毒素膳食暴露评估.中国食品卫生杂志，2007，19（3）: 832，932，42.

Wang J, Liu X M. Assessment of dietary aflatoxins exposure in Chinese residents. Chinese Journal of Food Hygiene, 2007, 19(3): 832, 932, 42. (in Chinese)

[47]Sugita-Konishi Y, Sato T, Saito S, Nakajima M, Tabata S, Tanaka T, Norizuki H, Itoh Y, Kai S, Sugiyama K, Kamata Y, Yoshiike N, Kumagai S. Exposure to aflatoxins in Japan: risk assessment for aflatoxin B1. Food Additives and Contaminants: Part A, 2010, 27(3): 365-372.

[48]Signorini M L, Gaggiotti M, Molineri A, Chiericatti C A, Zapata de Basílico M L, Basílico J C, Pisani M. Exposure assessment of mycotoxins in cow’s milk in Argentina. Food and Chemical Toxicology, 2012, 50:250-257.

[49]丁小霞，李培武，白艺珍，周海燕，印南日. 中国花生黄曲霉毒素风险评估中膳食暴露非参数概率评估方法. 中国油料作物学报, 2011, 33 (4):402-408.

Ding X X, Li P W, Bai Y Z, Zhou H Y, Yin N R. Non-parametric probability assessment of risk evaluation on dietary exposure to Chinese peanut aflatoxins. Chinese Journal of Oil Crop Sciences, 2011, 33(4): 402-408. (in Chinese) 

[50]Renwick A G, Barlow S, Hertz-Picciotto I, Boobis A R, Dybing E, Edler L, Eisenbrand G, Grieg J B, Kleiner J, Lambe J, Muller D J G, Smith M R, Tritscher A, Tuijelaars S, Brandt P A, Walker R, Kroes R. Risk characterisation of chemicals in food and diet. Food and Chemical Toxicology, 2003, 41: 1211-1271.

[51]Renwick A G. Risk characterization of chemicals in food. Toxicology Letters, 2004, 149: 163-176.

[52]O’Brien J, Renwick A G, Constable A, Dybing E, Müller D J G, Schlatter J, Slob W, Tueting W, Benthem J, Williams G M, Wolfreys A. Approaches to the risk assessment of genotoxic carcinogens in food: a critical appraisal. Food and Chemical Toxicology, 2006, 44: 1613-1635.

[53]European Food Safety Authority (EFSA). Opinion of the scientific panel on contaminants in the food chain on a request from EFSA related to harmonized approach for risk assessment of substances which are both genotoxic and carcinogenic. The EFSA Journal, 2005, 282: 1-31.

[54]Joint FAO/WHO Expert Committee on Food Additives. Evaluation of certain food contaminants. WHO Technical Report Series, 2006, 930: 8-61.

[55]Benford D, Leblanc J C, Setzer R W. Application of the margin of exposure (MOE) approach to substances in food that are genotoxic and carcinogenic. Food and Chemical Toxicology, 2010, 48: 34-41.

[56]Joint FAO/WHO Expert Committee on Food Additives. Evaluation of certain mycotoxin in food. WHO Technical Report Series, 2002, 906: 8-16.
[1] GUO Can,YUE XiaoFeng,BAI YiZhen,ZHANG LiangXiao,ZHANG Qi,LI PeiWu. Research on the Application of a Balanced Sampling-Random Forest Early Warning Model for Aflatoxin Risk in Peanut [J]. Scientia Agricultura Sinica, 2022, 55(17): 3426-3436.
[2] JING Dan, YUE XiaoFeng, BAI YiZhen, GUO Can, DING XiaoXia, LI PeiWu, ZHANG Qi. The Infectivity of Aspergillus flavus in Peanut [J]. Scientia Agricultura Sinica, 2021, 54(23): 5008-5020.
[3] ZHANG Qiao,WANG Ke. The Uncertainty of Agricultural Yield Risk Assessment and Agricultural Insurance Pricing: Literature Review and Wayforward [J]. Scientia Agricultura Sinica, 2021, 54(22): 4778-4786.
[4] HUI YuanYuan,PENG HaiShuai,WANG BiNi,ZHANG FuXin,LIU YuFang,JIA Rong,REN Rong. Research Progress of Food-Borne Pathogen Detection Based on Electrochemical and Optical Aptasensors [J]. Scientia Agricultura Sinica, 2021, 54(11): 2419-2433.
[5] LI XiaoBei,ZHAO XiaoYan,LI JianYing,CHEN Lei,ZHOU ChangYan,HE XiangWei. Residue Behavior and Dietary Intake Risk Assessment of Imidaclothiz in Pakchoi (Brassica chinensis L.) [J]. Scientia Agricultura Sinica, 2020, 53(17): 3587-3596.
[6] GONG AnDong,DONG FeiYan,WU NanNan,KONG XianWei,ZHAO Qian,YAN JianLi,Cheelo DIMUNA. Inhibitory Effect of Dimethyl Disulfide from Burkholderia pyrrocinia WY6-5 on Aspergillus flavus and Aflatoxins in Peanuts During Storage Period [J]. Scientia Agricultura Sinica, 2019, 52(17): 2972-2982.
[7] JIA ShiRong. Risk Assessment and Regulation of Genetically Engineered Crops: History and Reformation [J]. Scientia Agricultura Sinica, 2018, 51(4): 601-612.
[8] HU GuiXian, LAI AiPing, YUAN YuWei, ZHANG ZhiHeng, ZHAO ShouPing, ZHU JiaHong, WANG Qiang. Cumulative Risk Assessment of Dietary Sulfur Dioxide Residues of Consumers [J]. Scientia Agricultura Sinica, 2017, 50(7): 1317-1325.
[9] LI ZhiXia, NIE JiYun, YAN Zhen, ZHANG XiaoNan, GUAN DiKai, SHEN YouMing, CHENG Yang. Progress in Research of Detection, Risk Assessment and Control of the Mycotoxins in Fruits and Fruit Products [J]. Scientia Agricultura Sinica, 2017, 50(2): 332-347.
[10] JI Cheng, JIA Ru, ZHAO LiHong. Application of Gene Engineering Technique in Aflatoxin Biodegradation [J]. Scientia Agricultura Sinica, 2017, 50(17): 3422-3428.
[11] YE Meng-liang, NIE Ji-yun, XU Guo-feng, YAN Zhen, ZHENG Li-jing. Residue and Dietary Exposure Risk Assessment of Four Pesticides in Apple [J]. Scientia Agricultura Sinica, 2016, 49(7): 1289-1302.
[12] WANG Chun-yi, YAO Peng-juan, ZHANG Ji-quan, REN Yi-fang. Risk Assessment of Cold and Hot Damages for Double-Cropping Early Rice (DCER) in Lower-Middle Reaches of the Yangtze River Basin [J]. Scientia Agricultura Sinica, 2016, 49(13): 2469-2483.
[13] WANG Yan-Ru-1, 2 , 4 , LI Pei-Wu-1, 2 , 3 , 4 , 5 , ZHANG Qi-1, 3 , 4 , DING Xiao-Xia-1, 4 , 5 , ZHANG Wen-1, 2 , 5 . Charericterization of a Phage-Displayed Nanobody Imitating Aflatoxin Antigen [J]. Scientia Agricultura Sinica, 2014, 47(4): 685-692.
[14] GAO Xiao-rong, WANG Chun-yi, ZHANG Ji-quan, WEN Xu. Risk Assessment and Zoning of the Main Meteorological Disasters for Maize in Northeast China [J]. Scientia Agricultura Sinica, 2014, 47(24): 4805-4820.
[15] GAO Xiao-rong, WANG Chun-yi, ZHANG Ji-quan, WEN Xu. A Risk Assessment System of the Main Meteorological Disasters for Maize in Northeast China [J]. Scientia Agricultura Sinica, 2014, 47(21): 4257-4268.
Viewed
Full text


Abstract

Cited
  Shared   
  Discussed   
No Suggested Reading articles found!
京ICP备09089781号-30
Copyright 2018 © Editorial office of Scientia Agricultura Sinica
Tel: 86-010-82106279    E-mail: zgnykx@mail.caas.net.cn
Supported by Beijing Magtech Co.Ltd