Scientia Agricultura Sinica ›› 2012, Vol. 45 ›› Issue (15): 3165-3175.doi: 10.3864/j.issn.0578-1752.2012.15.019

• ANIMAL SCIENCE·RESOURCE INSECT • Previous Articles     Next Articles

Genome-Wide Association of Thymus and Spleen Mass in Chicken

 ZHANG  Lei, ZHENG  Mai-Qing, LIU  Ran-Ran, WEN  Jie, WU  Dan, HU  Yao-Dong, SUN  Yan-Fa, LI  Peng, LIU  Li, ZHAO  Gui-苹   

  1. 中国农业科学院北京畜牧兽医研究所/农业部畜禽遗传资源与种质创新重点实验室,北京 100193
  • Received:2012-02-15 Online:2012-08-01 Published:2012-05-23

Abstract: 【Objective】 Genome-wide association study (GWAS) is a new strategy to identify genes and chromosome regions associated with complex traits.【Method】 A total of 728 Beijing-You chickens from 50 families were genotyped by 60K SNP Illumina iSelect chicken array. GWAS was performed to study the candidate loci affecting thymus weight and spleen weight at 100 days of age.【Result】 It was found that 24 SNPs were significantly associated with target traits at Bonferroni corrected 5% genome-wise threshold, including Janus kinase 1 (JAK1), zinc finger DHHC-type containing 8 (ZDHHC8)、vav 3 guanine nucleotide exchange factor (VAV3), SATB homeobox 1 (SATB1) and other genes near these SNPs,and 84 SNPs reached both the significance of ‘suggestive linkage’ and 5% chromosome-wise threshold.【Conclusion】 These indentified genes and SNPs offered essential information for understanding of the molecular mechanisms of immune organs development and facilitated the application of marker-assisted selection in diseases-resistance breeding program in chicken.

Key words: Beijing-You chicken, thymus mass, spleen mass, GWAS

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