关键词: 单倍型, 单标记, QTL

Abstract: Linkage disequilibrium has been extensively applied in the gene mapping and QTL detection. Present study analyzed the superiority and investigated the applied strategy of haplotype analysis in the QTL detection. Genotype data, releasing early this year, of 69 markers from Y chromosome and 269 human being individuals was sampled from databank. Haplotypes were then constructed and one hypothetic QTL locus was given. Capture efficiency of the QTL by haplotype method was investigated. In low degree of linkage disequilibrium, the result showed that the capture efficiency of QTL was zero when analyzing the flanking markers using single marker analysis method. When two, three and four flanking markers were used for haplotype analysis, the efficiency to capture the QTL was 33.3%, 66.7%, and 71.4%, respectively. For the QTL detection, the association analysis based on haplotype was significantly more powerful than the analysis based on single marker. This study will benefit to the research that use haplotype analysis method to detect QTL.

Key words: Haplotype, Single marker, QTL