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Special Issue:
动物医学合辑Veterninary Medicine
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| Protective efficacy of an H5/H7 trivalent inactivated vaccine produced from Re-11, Re-12, and H7-Re2 strains against challenge with different H5 and H7 viruses in chickens |
ZENG Xian-ying1*, CHEN Xiao-han1*, MA Shu-jie1, WU Jiao-jiao1, BAO Hong-mei1, PAN Shu-xin1, LIU Yan-jing1, DENG Guo-hua1, SHI Jian-zhong1, CHEN Pu-cheng1, JIANG Yong-ping1, LI Yan-bing1, HU Jing-lei2, LU Tong2, MAO Sheng-gang2, GUO Xing-fu2, LIU Jing-li2, TIAN Guo-bin1, CHEN Hua-lan1 |
1 State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin 150069, P.R.China
2 Harbin Weike Biotechnology Development Company, Harbin 150069, P.R.China |
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Abstract We developed an H5/H7 trivalent inactivated vaccine by using Re-11, Re-12, and H7-Re2 vaccine seed viruses, which were generated by reverse genetics and derived their HA genes from A/duck/Guizhou/S4184/2017(H5N6) (DK/GZ/S4184/17) (a clade 2.3.4.4d virus), A/chicken/Liaoning/SD007/2017(H5N1) (CK/LN/SD007/17) (a clade 2.3.2.1d virus), and A/chicken/Guangxi/SD098/2017(H7N9) (CK/GX/SD098/17), respectively. The protective efficacy of this novel vaccine and that of the recently used H5/H7 bivalent inactivated vaccine against different H5 and H7N9 viruses was evaluated in chickens. We found that the H5/H7 bivalent vaccine provided solid protection against the H7N9 virus CK/GX/SD098/17, but only 50–60% protection against different H5 viruses. In contrast, the novel H5/H7 trivalent vaccine provided complete protection against the H5 and H7 viruses tested. Our study underscores the importance of timely updating of vaccines for avian influenza control.
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Received: 05 July 2020
Accepted:
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| Fund: This work was supported by the National Key R&D Program of China (2016YFD0501602, 2017YFD0500701, and 2016YFE0203200), the National Natural Science Foundation of China (3167131307), the China Agriculture Research System (CARS-41-G12), and Central Public-interest Scientific Institution Basal Research Fund (1610302017001). |
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Corresponding Authors:
Correspondence CHEN Hua-lan, Tel: +86-451-51997168, Fax: +86-451-51997166, E-mail: chenhualan@caas.cn; TIAN Guo-bin, Tel: +86-451-51051681, Fax: +86-451-51997166, E-mail: tianguobin@caas.cn
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| About author: ZENG Xian-ying, E-mail: zengxianying@caas.cn; * These authors contributed equally to this study. |
Cite this article:
ZENG Xian-ying, CHEN Xiao-han, MA Shu-jie, WU Jiao-jiao, BAO Hong-mei, PAN Shu-xin, LIU Yan-jing, DENG Guo-hua, SHI Jian-zhong, CHEN Pu-cheng, JIANG Yong-ping, LI Yan-bing, HU Jing-lei, LU Tong, MAO Sheng-gang, GUO Xing-fu, LIU Jing-li, TIAN Guo-bin, CHEN Hua-lan.
2020.
Protective efficacy of an H5/H7 trivalent inactivated vaccine produced from Re-11, Re-12, and H7-Re2 strains against challenge with different H5 and H7 viruses in chickens. Journal of Integrative Agriculture, 19(9): 2294-2300.
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