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| Dynamic Change of Genetic Diversity in Conserved Populations with Different Initial Genetic Architectures |
| LU Yun-feng, LI Hong-wei, WU Ke-liang, WU Chang-xin |
1.College of Animal Science and Technology, China Agricultural University, Beijing 100193, P.R.China
2.School of Life Science and Technology, Nanyang Normal University, Nanyang 473061, P.R.China
3.National Engineering Laboratory for Animal Breeding, Beijing 100193, P.R.China |
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摘要 Maintenance and management of genetic diversity of farm animal genetic resources (AnGR) is very important for biological, socioeconomical and cultural significance. The core concern of conservation for farm AnGR is the retention of genetic diversity of conserved populations in a long-term perspective. However, numerous factors may affect evolution of genetic diversity of a conserved population. Among those factors, the genetic architecture of conserved populations is little considered in current conservation strategies. In this study, we investigated the dynamic changes of genetic diversity of conserved populations with two scenarios on initial genetic architectures by computer simulation in which thirty polymorphic microsatellite loci were chosen to represent genetic architecture of the populations with observed heterozygosity (Ho) and expected heterozygosity (He), observed and mean effective number of alleles (Ao and Ae), number of polymorphic loci (NP) and the percentage of polymorphic loci (PP), number of rare alleles (RA) and number of non-rich polymorphic loci (NRP) as the estimates of genetic diversity. The two scenarios on genetic architecture were taken into account, namely, one conserved population with same allele frequency (AS) and another one with actual allele frequency (AA). The results showed that the magnitude of loss of genetic diversity is associated with genetic architecture of initial conserved population, the amplitude of genetic diversity decline in the context AS was more narrow extent than those in context AA, the ranges of decline of Ho and Ao were about 4 and 2 times in AA compared with that in AS, respectively, the occurrence of first monomorphic locus and the time of change of measure NP in scenario AA is 20 generations and 23 generations earlier than that in scenario AS, respectively. Additionally, we found that NRP, a novel measure proposed by our research group, was a proper estimate for monitoring the evolution of genetic diversity in a closed conserved population. Our study suggested that current managements of conserved populations should emphasize on initial genetic architecture in order to make an effective and feasible conservation scheme.
Abstract Maintenance and management of genetic diversity of farm animal genetic resources (AnGR) is very important for biological, socioeconomical and cultural significance. The core concern of conservation for farm AnGR is the retention of genetic diversity of conserved populations in a long-term perspective. However, numerous factors may affect evolution of genetic diversity of a conserved population. Among those factors, the genetic architecture of conserved populations is little considered in current conservation strategies. In this study, we investigated the dynamic changes of genetic diversity of conserved populations with two scenarios on initial genetic architectures by computer simulation in which thirty polymorphic microsatellite loci were chosen to represent genetic architecture of the populations with observed heterozygosity (Ho) and expected heterozygosity (He), observed and mean effective number of alleles (Ao and Ae), number of polymorphic loci (NP) and the percentage of polymorphic loci (PP), number of rare alleles (RA) and number of non-rich polymorphic loci (NRP) as the estimates of genetic diversity. The two scenarios on genetic architecture were taken into account, namely, one conserved population with same allele frequency (AS) and another one with actual allele frequency (AA). The results showed that the magnitude of loss of genetic diversity is associated with genetic architecture of initial conserved population, the amplitude of genetic diversity decline in the context AS was more narrow extent than those in context AA, the ranges of decline of Ho and Ao were about 4 and 2 times in AA compared with that in AS, respectively, the occurrence of first monomorphic locus and the time of change of measure NP in scenario AA is 20 generations and 23 generations earlier than that in scenario AS, respectively. Additionally, we found that NRP, a novel measure proposed by our research group, was a proper estimate for monitoring the evolution of genetic diversity in a closed conserved population. Our study suggested that current managements of conserved populations should emphasize on initial genetic architecture in order to make an effective and feasible conservation scheme.
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Accepted:
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| Fund: This work was partly supported by the program for Changjiang Scholar and Innovation Research Team in University, China (IRT1191), the Beijing Science and Technology Project, China (Z080005022208015) and the Chinese Universities Scientific Fund (2012YJ058). |
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Corresponding Authors:
Correspondence WU Ke-liang, Tel/Fax: +86-10-62734767, E-mail: liangkwu@cau.edu.cn
E-mail: liangkwu@cau.edu.cn
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| About author: LU Yun-feng, E-mail: luyunfeng6@yahoo.com.cn; |
Cite this article:
LU Yun-feng, LI Hong-wei, WU Ke-liang, WU Chang-xin.
2013.
Dynamic Change of Genetic Diversity in Conserved Populations with Different Initial Genetic Architectures. Journal of Integrative Agriculture, 12(7): 1225-1233.
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| [1]Allendorf F W. 1986. Genetic drift and the loss of allelesversus heterozygosity. Zoo Biology, 5, 181-190[2]Anderson S. 2003. Animal genetic resources and sustainablelivelihoods. Ecological Economics, 45, 331-339[3]Armbruster G, Pfenninger M. 2003. Simulated bottlenecksand loss of rare alleles: implications on the conservationgenetics of two gastropod species. Journal for NatureConservation, 11, 77-81[4]Askari N, Abadi M M, Baghizadeh A. 2011. ISSR markersfor assessing DNA polymorphism and geneticcharacterization of cattle, goat and sheep populations.Iranian Journal of Biotechnology, 9, 222-229[5]Barker J S F. 1999. Conservation of livestock breed diversity.Animal Genetic Resources Information, 25, 33-43[6]Blott S, Andersson L, Groenen M, SanCristobal M, ChevaletC, Cardellino R, Li N, Huang L, Li K, Plastow G, et al.2003. Characterisation of genetic variation in the pigbreeds of China and Europe - The PigBioDiv2 Project.Archivos de Zootecnia, 52, 207-217[7]Boettcher P J, Tixier-Boichard M, Toro M A, Simianer H,Eding H, Gandini G, Joost S, Garcia D, Colli L, Ajmone-Marsan P, et al. 2010. Objectives, criteria and methodsfor using molecular genetic data in priority setting forconservation of animal genetic resources. AnimalGenetics, 41(Suppl. 1), 64-77[8]Butlin R K, Tregenza T. 1998. Levels of geneticpolymorphism: marker loci versus quantitative traits.Philosophical Transactions of the Royal Society ofLondon (Series B - Biological Sciences), 353, 187-198[9]Cañón J, Alexandrino P, Bessa I, Carleos C, Carretero Y,Dunner S, Ferran N, Garcia D, Jordana J, Laloë D, et al.2001. Genetic diversity measures of local European beefcattle breeds for conservation purposes. GeneticsSelection Evolution, 33, 311-332[10]Caballero A, Rodríguez-Ramilo S T. 2010. A new method forthe partition of allelic diversity within and betweensubpopulations. Conservation Genetics, 11, 2219-2229[11]Caballero A, Rodríguez-Ramilo S T, Avila V, Fernández J.2010. Management of genetic diversity of subdividedpopulations in conservation programmes.Conservation Genetics, 11, 409-419[12]Ebrahimi A, Fatahi R, Zamani Z. 2011. Analysis of geneticdiversity among some Persian walnut genotypes(Juglans regia L.) using morphological traits and SSRsmarkers. Scientia Horticulturae, 130, 146-151[13]Falconer D S, Mackay T F C. 1996. Introduction toQuantitative Genetics. 4th ed. Essex, Longman, UK.pp. 82-86[14]Fernández J, Toro M A, Caballero A. 2004. Managingindividuals’s contributions to maximize the allelicdiversity maintained in small, conserved populationss.Conservation Biology, 18, 1358-1367[15]Food and Agriculture Organization of the United Nations.1998. Secondary guidelines for development of nationalfarm animal genetic resources management plans.Management of small populations at risk. [2010-10-20][16]http://dad.fao.org/en/refer/library/guidelin/sml-popn.pdfFood and Agriculture Organization of the United Nations.2007. The state of the world’s animal genetic resourcesfor food and agriculture. [2010-10-20] http://www.fao.org/docrep/010/a1250e/a1250e00.htmFood and Agriculture Organization of the United Nations.2011. The state of food insecurity of the world: Howdoes international price volatility affect domesticeconomies and food security? [2012-5-26][17]http://www.fao.org/docrep/014/i2330e/i2330e.pdfFrankham R. 2010. Challenges and opportunities of geneticapproaches to biological conservation. BiologicalConservation, 143, 1919-1927[18]Gandini G C, Villa E. 2003. Analysis of the cultural value oflocal livestock breeds: a methodology. Journal ofAnimal Breeding and Genetics, 120, 1-11[19]Hoffmann I. 2011. Livestock biodiversity and sustainability.Livestock Science, 139, 69-79[20]Lauvie A, Audiot A, Couix N, Casabianca F, Brives H,Verrier E. 2010. Diversity of rare breed managementprograms: Between conservation and development.Livestock Science, 140, 161-170[21]Lewontin R C, Krakauep J. 1973. Distrubution of genefrequency as test of the theory of the selective nuetralityof polymorphisms. Genetics, 74, 175-195[22]Luo W, Cheng D, Chen S, Wang L, Li Y, Ma X, Song X, LiuX, Li W, Liang J, et al. 2012. Genome-wide associationanalysis of meat quality traits in a porcine LargeWhite×Minzhu intercross population. InternationalJournal of Biological Sciences, 8, 580-595[23]Lynch M, Pfrender M, Spitze K, Lehman N, Hicks J, AllenD, Latta L, Ottene M, Bogue F, Colbourne J. 1999. Thequantitative and molecular genetic architecture of asubdivided species. Evolution, 53, 100-110[24]Mendelsohn R. 2003. The challenge of conservingindigenous domesticated animals. EcologicalEconomics, 45, 501-510[25]Montgomery M E, Woodworth L M, Nurthen R K, GilliganD M, Briscoe D A, Frankham R. 2000. Relationshipsbetween population size and loss of genetic diversity:comparisons of experimental results with theoreticalpredictions. Conservation Genetics, 1, 33-43[26]Mtileni B J, Muchadeyi F C, Maiwashe A, Groeneveld E,Groeneveld L F, Dzama K ,Weigend S. 2011. Geneticdiversity and conservation of South Africanindigenous chicken populations. Journal of AnimalBreed Genetics, 128, 209-218[27]Nei M, Maruyama T, Chakraborty R. 1975. The bottleneckeffect and genetic variability in populations. Evolution29, 1-10[28]Notter D R. 1999. The importance of genetic diversity inlivestock populations of the future. Journal of AnimalScience, 77, 61-69[29]Pastoret P P. 2012. Reducing hazards for animals fromhumans. Italian Journal of Public Health, 9, 25-28[30]Robinson P, Bray D F. 1965. Expected effects on theinbreeding coefficient and rate of gene loss of fourmethods of reproducing finite diploid populations.Biometrics, 21, 447-458[31]Ruane J. 2000. A framework for prioritizing domestic animalbreeds for conservation purposes at the national level:a Norwegian case study. Conservation Biology, 14,1385-1393[32]Schaal B A, Leverich W J, Rogstad S H. 1991. Comparisonof methods for assessing genetic variation in plantconservation biology. In: Falk D A, Holsinger K E, eds.,Genetics and Conservation of Rare Plants. OxfordUniversity Press, New York. pp. 123-134[33]Silva A C M, Paiva S R, Albuquerque M S M, Egito A A,Santos S A, Lima F C, Castro S T, Mariante A S, CorreaP S, McManus C M. 2012. Genetic variability in localBrazilian horse lines using microsatellite markers.Genetics and Molecular Research, 11, 881-890[34]Sjögren P, Wyöni P I. 1994. Conserbation genetics anddetection of rare alleles in finite population.Conservation Biology, 8, 267-270[35]Toro M, SilióL, Rodriganez J, Rodriguez C, Fernández J.1999. Optimal use of genetic markers in conservationprogrammes. Genetics Selection Evolution, 31, 255-261[36]Toro M A, Fernández J, Caballero A. 2009. Molecularcharacterization of breeds and its use in conservation.Livestock Science, 120, 174-195[37]Toro M A, Caballero A. 2005. Characterization andconservation of genetic diversity in subdividedpopulations. Philosophical Transactions of the RoyalSociety of London (Series B - Biological Sciences), 360,1367-1378[38]Wu C X. 1999. Theory and technology of conservation ofanimal genetic resources: germplasm base ofsustainable development of animal husbandry in 21century. Journal of Yunnan University, 21, 7-10. (in Chinese) |
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