Abstract:

【Objective】 The repair effects of selenium-enriched goose fatty liver on hyperlipemia in rats were studied.【Method】Seventy-two Wistar male rats with body weight around 150-180 g were divided into 8 groups including control group, obesity model group, goose fatty liver group (low dose, middle dose, high dose) and selenium-enriched goose fatty liver group (low dose, middle dose, high dose) after 5 days of feeding. Rats in control and obesity model groups were administered with distilled water at the dose of 20 g?kg-1 BW. Rats in low dose, middle dose and high dose groups were administered with goose fatty liver or selenium-enriched goose fatty liver at the doses of 10 g, 20 g, and 3 0 g?kg-1 BW, respectively. Rats in control group were fed with basic feed, and the other seven groups were fed with high fat feeds. The effect of feeds on growth, indexes of lipid metabolism and microscope pathomorphism were analyzed after 8 weeks of feeding. 【Result】 Compared with obesity model group, low dose of goose fatty liver reduced kidney surrounding fat significantly (P＜0.05). Low dose of selenium-enriched goose fatty liver reduced kidney surrounding fat ratio, testicle surrounding fat amount and testicle surrounding fat ratio, body fat amount and body fat ratio significantly (P＜0.05). The body length of low dose group of selenium-enriched goose fatty liver was significant lower (P＜0.05) than that of the low dose group of goose fatty liver. Compared with obesity model group, low dose of goose fatty liver reduced serum triglycerides content (TG) significantly (P＜0.05). Middle dose of goose fatty liver reduced the content of TG, total cholesterol (TC), low density lipoprotein-cholesterol (LDL-C) (P＜0.05) and arteriosclerosis index (AI) significantly (P＜0.01). High dose of goose fatty liver reduced the content of LDL-C and AI significantly (P＜0.05). Low and middle doses of selenium-enriched goose fatty liver reduced the content of TG, TC, LDL-C (P＜0.05) and AI significantly (P＜0.01). High dose of selenium-enriched goose fatty liver reduced the content of LDL-C (P＜0.05) and AI significantly (P＜0.01). Compared with low dose group of goose fatty liver, low dose of selenium-enriched goose fatty liver reduced AI significantly (P＜0.01). Compared with obesity model group, low and middle doses of goose fatty liver increased the activity of total lipase (LA) (P＜0.05), high dose of goose fatty liver could enhanced the activities of hepatic lipase (HL) and LA (P＜0.05).Low and middle doses of selenium-enriched goose fatty liver increased the activity of lipoprotein lipase (LPL) and LA (P＜0.05), and reduced the content of lipofuscin (LP) (P＜0.05). High dose of selenium-enriched goose fatty liver increased the activities of LA, LPL and HL (P＜0.05). Compared with low dose group of goose fatty liver, low dose of selenium-enriched goose fatty liver increased the activity of LPL and LA (P＜0.05) Compared with middle dose group of goose fatty liver, middle dose of selenium-enriched goose fatty liver increased the activity of LPL(P＜0.05) and LA (P＜0.01). Compared with high dose group of goose fatty liver, high dose of selenium-enriched goose fatty liver increased the activity of LPL (P＜0.05). The liver adipose degeneration was ameliorated in some degree in all groups of goose fatty liver and selenium-enriched goose fatty liver, especially in low and middle group.【Conclusion】Both goose fatty liver and selenium-enriched goose fatty liver can improve lipid metabolism and have significant effects on decreasing blood fat and on resisting arteriosclerosis and on repairing hepatic steatosis of rats. Selenium-enriched goose fatty liver is better than goose fatty liver.

Key words: Selenium-enriched goose fatty liver, rats, hyperlipemia