Scientia Agricultura Sinica ›› 2012, Vol. 45 ›› Issue (5): 943-950.doi: 10.3864/j.issn.0578-1752.2012.05.015

• STORAGE·FRESH-KEEPING·PROCESSING • Previous Articles     Next Articles

Effect of Lactobacillus casei Zhang Administration on Liver Lipids Metabolism of High-Fat Diet Induced Hypercholesterolemia Rats

 ZHANG  Yong, DU  Rui-Ting, HE  Qiu-Wen, LI  He, ZHANG  He-Ping   

  1. 1.内蒙古农业大学食品科学与工程学院/国家奶牛产业技术体系乳制品研究室/乳品生物技术与工程教育部重点实验室,呼和浩特 010018
    2.江南大学食品科学与技术学院,江苏无锡214122
  • Received:2011-10-11 Online:2012-03-01 Published:2011-12-26

Abstract: 【Objective】 The therapeutic effect of different doses of L. casei Zhang (2.0×1010 CFU/d, 2.0×109 CFU/d and 2.0×108 CFU/d) and its fermented milk beverage (2.0×108 CFU/mL/d) on liver lipids of hypercholesterolemia rats was investigated. 【Method】Hypercholesterolemia rats were induced by high fat feeding. Liver TC and TG levels, fecal total bile acid and cholesterol levels as well as serum ApoAⅠand ApoB levels were dertermined by commercial kits. 【Result】 The results showed that liver TC and TG levels were significantly decreased in all probiotic treatment groups compared to hypercholesterolemia model group (P<0.05 or P<0.01). In addition, fecal total bile acid levels and serum ApoAⅠlevels were significantly promoted and serum ApoB levels significantly reduced in all probiotic treatment groups compared to model group, while fecal cholesterol levels were changed with no significance (P>0.05). 【Conclusion】 It is suggested that enhancing elimination of bile acids and regulating apolipoprotein levels could be mainly contributed to liver lipids ameliorated by probiotic L. casei Zhang in hypercholesterolemia rats.

Key words: Lactobacillus casei Zhang, liver lipids, hypercholesterolemia rats, fecal total bile acid level, apolipoprotein, fecal cholesterol level

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