Abstract: Wuzhishan mini-pig (WZSP) is one of the scarce breeds, which is becoming extinct in China, the weight of sow is about 35-40 kg at 24-month-old of age. Since ex-situ breeding successful in WZSP and inbred line of WZSP in the world has made a progress by scientists of CAAS for nearly 20 years. Now, F19 has been obtained already, the inbreeding coefficient has reached 0.983. A series of studies have been carried out on germplam evaluation, laboratory rearing and inbreeding including inbreeding evaluation, performances of growth-development, evaluation of physiological and biochemical values, characteristics of molecular genetics，exploitation and application. The results shown that WZSP with small size, light body weight, early sexual maturity and high quality of meat production and also shown that WZSPs Microsatellite with Specific Allele, without MHSn gene, GH′s and GHR′s sequences is quite different from normal pigs, SLA types are similar to human and so on. It is not only the ideal material for pig’s meat breeding, but also the best choice for laboratory animals. It will make a special contribution to human model and xenotransplantation in the future.

Key words: Wuzhishan mini-pig , Inbred line , Molecular genetics