Abstract: 【Objective】The damage effect and cellular biological relationship of animal and plant cell by Rhizoctonia leguminicola and its secondary metabolites was stueied. All these can provide new thoughtfulness for the study on toxicology. 【Method】The Rhizoctonia leguminicola and the secondary metabolites of Rhizoctonia leguminicola were interfused into feedingstuff of the rabbit, and these rabbits were fed for 17 days, then the rabbits were killed and pathological obserbvation of brain, liver, kidney was carried out under optical microscope and TEM. 【Result】In the experiment of the damage effects of cells from animal and plant body by the secondary metabolites of Rhizoctonia leguminicola, the rabbit brain and lymphocyte showed vacuolar degeneration, and the granule of ribosome was broken off in neurocyte, and also expressed dilatation of RER. And the plant root tissue expressed the structural damage, and the cell showed vacuolar degeneration and breach of the inner membrane. 【Conclusion】These results show that the reason of poisoning of Rhizoctonia leguminicola to animal is that SW in the secondary metabolites bring into important play, and this effect is identical with locoweed toxicosis basically. The damage of the plant cell had positive correlation with the content of SW in the the secondary metabolites of Rhizoctonia leguminicola. It is suspected that SW is not only a kind of important toxin in the toxicosis of animal, but also a sort of chemical substance in the cell damage of legume plant.

Key words: Rhizoctonia leguminicola, Secondary metabolites, Swainsonine, Toxicity