关键词: 利巴韦林')">利巴韦林, 猪, 毒性反应

Abstract:

【Objective】 The aim of this study was to investigate the toxic effect of different doses of ribavirin on pigs.【Method】 Twelve pigs were randomly divided into 4 groups including a control group and three experimental groups in order to investigate the toxic effect of different doses of ribavirin on pigs. Ribavirin was administered once daily for 10 consecutive days at a dose of either 10, 30, or 90 mg?kg-1. The toxic effects were observed by ethology, blood, serum, urine, bone marrow and pathologic changes before and after administation. 【Result】 The results of this study in pigs indicated that there was no intoxicated significant toxic change between the experimental groups with a daily administration of ribavirin at a dose of 10 mg?kg-1 and the control group, but daily administration of ribavirin at a doses of 30 to 90 mg?kg-1 induced a dose-related toxic effect. The toxic effect showed that the pantropic toxicity and pathological changes in blood, bone marrow, gastrointestinal tract, pancreas, heart, liver, kidney and brain.Hemolytic anemia was the primary mechanism for the pathogenesis of pig poisoning, the reasons which resulted in the loss of appetite and constipation were catarrhal inflammation and necrotizing inflammation of gastrointestinal tract and pancreatopathy. 【Conclusion】 In summary, high doses of ribavirin can increase the risk of death of pigs, so the use of ribavirin for the treatment of swine diseases is not recommended.

Key words: ribavirin')">ribavirin, pig, toxicologic effect