Albert N W, Davies K M, Lewis D H, Zhang H, Montefiori M, Brendolise C, Boase M R, Ngo H, Jameson P E, Schwinn K E. 2014. A conserved network of transcriptional activators and repressors regulates anthocyanin pigmentation in eudicots. The Plant Cell, 26, 962–980.

Ali M Y, Zamponi G W, Abdul Q A, Seong S H, Min B S, Jung H A, Choi J S. 2024. Prunin from Poncirus trifoliata (L.) Rafin inhibits aldose reductase and glucose-fructose-mediated protein glycation and oxidation of human serum albumin. Journal of Agricultural and Food Chemistry, 72, 7203–7218.

Bhakta S, Negi S, Tak H, Singh S, Ganapathi T R. 2022. MusaATAF2-like protein regulates shoot development and multiplication by inducing cytokinin hypersensitivity and flavonoid accumulation in banana plants. Plant Cell Reports, 41, 1197–1208.

Cao Y, Mei Y, Zhang R, Zhong Z, Yang X, Xu C, Chen K, Li X. 2024a. Transcriptional regulation of flavonol biosynthesis in plants. Horticulture Research, 11, uhae043.

Cao Y, Zhang R, Ou R, Mei Y, Cui X, Zhang T, Yang X, Shi Y, Zhao X, Xu C, Chen K, Li X. 2024b. Overexpression of MrMYB12 or MrMYB12/MrF3’5’H results in flavonol-rich tomato fruit that improves resistance against Botrytis cinerea during the shelf life period. Postharvest Biology and Technology, 211, 112818.

Cao Y, Zhang R, Xing M, Ren C, Li J, Qian J, Mei Y, Yang X, Sun C, Grierson D, Chen K, Xu C, Li X. 2023. Synergistic actions of three MYB transcription factors underpins the high accumulation of myricetin in Morella rubra. The Plant Journal, 115, 577–594.

Cavallini E, Matus J T, Finezzo L, Zenoni S, Loyola R, Guzzo F, Schlechter R, Ageorges A, Arce-Johnson P, Tornielli G B. 2015. The phenylpropanoid pathway is controlled at different branches by a set of R2R3-MYB C2 repressors in grapevine. Plant Physiology, 167, 1448–1470.

Chen C, Wu Y, Li J, Wang X, Zeng Z, Xu J, Liu Y, Feng J, Chen H, He Y, Xia R. 2023. TBtools-II: A “one for all, all for one” bioinformatics platform for biological big-data mining. Molecular Plant, 16, 1733–1742.

Cong L, Qu Y, Sha G, Zhang S, Ma Y, Chen M, Zhai R, Yang C, Xu L, Wang Z. 2021. PbWRKY75 promotes anthocyanin synthesis by activating PbDFR, PbUFGT, and PbMYB10b in pear. Physiologia Plantarum, 173, 1841–1849.

Czemmel S, Stracke R, Weisshaar B, Cordon N, Harris N N, Walker A R, Robinson S P, Bogs J. 2009. The grapevine R2R3-MYB transcription factor VvMYBF1 regulates flavonol synthesis in developing grape berries. Plant Physiology, 151, 1513–1530.

Deng X, Cheng L, Qiao Y, Liu X, Zhou Y, Liu H, Wang L. 2024. Rutin ameliorates HCD-induced cholesterol metabolism disorder in zebrafish larvae revealed by transcriptome and metabolome analysis. Phytomedicine, 135, 156058.

Dong R, Zhang X, Liu Y, Zhao T, Sun Z, Liu P, Xiang Q, Xiong J, Du X, Yang X, Gui D, Xu Y. 2023. Rutin alleviates EndMT by restoring autophagy through inhibiting HDAC1 via PI3K/AKT/mTOR pathway in diabetic kidney disease. Phytomedicine, 112, 154700.

Funaki A, Waki T, Noguchi A, Kawai Y, Yamashita S, Takahashi S, Nakayama T. 2015. Identification of a highly specific isoflavone 7-O-glucosyltransferase in the soybean (Glycine max (L.) Merr.). Plant and Cell Physiology, 56, 1512–1520.

Gao Y, Lin Y, Xu M, Bian H, Zhang C, Wang J, Wang H, Xu Y, Niu Q, Zuo J, Fu D, Pan Y, Chen K, Klee H, Lang Z, Zhang B. 2022. The role and interaction between transcription factor NAC-NOR and DNA demethylase SlDML2 in the biosynthesis of tomato fruit flavor volatiles. New Phytologist, 235, 1913–1926.

Griesser M, Vitzthum F, Fink B, Bellido M L, Raasch C, Munoz-Blanco J, Schwab W. 2008. Multi-substrate flavonol O-glucosyltransferases from strawberry (Fragaria×ananassa) achene and receptacle. Journal of Experimental Botany, 59, 2611–2625.

Han X, Zhao S, Song H, Xu T, Fang Q, Hu G, Sun L. 2021. Kaempferol alleviates LD-mitochondrial damage by promoting autophagy: Implications in Parkinson’s disease. Redox Biology, 41, 101911.

Jin H, Cominelli E, Bailey P, Parr A, Mehrtens F, Jones J, Tonelli C, Weisshaar B, Martin C. 2000. Transcriptional repression by AtMYB4 controls production of UV-protecting sunscreens in Arabidopsis. The EMBO Journal, 19, 6150–6161.

Jun J H, Liu C, Xiao X, Dixon R A. 2015. The transcriptional repressor MYB2 regulates both spatial and temporal patterns of proanthocyandin and anthocyanin pigmentation in Medicago truncatula. The Plant Cell, 27, 2860–2879.

Khan I A, Cao K, Guo J, Li Y, Wang Q, Yang X, Wu J, Fang W, Wang L. 2022. Identification of key gene networks controlling anthocyanin biosynthesis in peach flower. Plant Science, 316, 111151.

Kumar S P, Birundha K, Kaveri K, Devi K T R. 2015. Antioxidant studies of chitosan nanoparticles containing naringenin and their cytotoxicity effects in lung cancer cells. International Journal of Biological Macromolecules, 78, 87–95.

Li H, Li Y, Yu J, Wu T, Zhang J, Tian J, Yao Y. 2020. MdMYB8 is associated with flavonol biosynthesis via the activation of the MdFLS promoter in the fruits of Malus crabapple. Horticulture Research, 7, 19.

Li J, Scarano A, Gonzalez N M, D’Orso F, Yue Y, Nemeth K, Saalbach G, Hill L, De Oliveira Martins C, Moran R, Santino A, Martin C. 2022. Biofortified tomatoes provide a new route to vitamin D sufficiency. Nature Plants, 8, 611–616.

Li Y, Shan X, Gao R, Han T, Zhang J, Wang Y, Kimani S, Wang L, Gao X. 2020. MYB repressors and MBW activation complex collaborate to fine-tune flower coloration in Freesia hybrida. Communications Biology, 3, 396.

Li Z, Zhang Y, Ren J, Jia F, Zeng H, Li G, Yang X. 2022. Ethylene‐responsive factor ERF114 mediates fungal pathogen effector PevD1-induced disease resistance in Arabidopsis thaliana. Molecular Plant Pathology, 23, 819–831.

Lin S, Li H, Tao Y, Liu J, Yuan W, Chen Y, Liu Y, Liu S. 2020. In vitro and in vivo evaluation of membrane-active flavone amphiphiles: Semisynthetic kaempferol-derived antimicrobials against drug-resistant gram-positive bacteria. Journal of Medicinal Chemistry, 63, 5797–5815.

Liu G, Li C, Yu H, Tao P, Yuan L, Ye J, Chen W, Wang Y, Ge P, Zhang J, Zhou G, Zheng W, Ye Z, Zhang Y. 2020. GREEN STRIPE, encoding methylated TOMATO AGAMOUS-LIKE 1, regulates chloroplast development and Chl synthesis in fruit. New Phytologist, 228, 302–317.

Liu J, Osbourn A, Ma P. 2015. MYB transcription factors as regulators of phenylpropanoid metabolism in plants. Molecular Plant, 8, 689–708.

Liu X, Lin C, Ma X, Tan Y, Wang J, Zeng M. 2018. Functional characterization of a flavonoid glycosyltransferase in sweet orange (Citrus sinensis). Frontiers in Plant Science, 9, 166.

Love M I, Huber W, Anders S. 2014. Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2. Genome Biology, 15, 550.

Ma D, Constabel C P. 2019. MYB repressors as regulators of phenylpropanoid metabolism in plants. Trends in Plant Science, 24, 275–289.

Ma X, Zhang Q, Zhu Q, Liu W, Chen Y, Qiu R, Wang B, Yang Z, Li H, Lin Y, Xie Y, Shen R, Chen S, Wang Z, Chen Y, Guo J, Chen L, Zhao X, Dong Z, Liu Y G. 2015. A robust CRISPR/Cas9 system for convenient, high-efficiency multiplex genome editing in monocot and dicot plants. Molecular Plant, 8, 1274–1284.

Modolo LV, Li L, Pan H, Blount J W, Dixon R A, Wang X. 2009. Crystal structures of glycosyltransferase UGT78G1 reveal the molecular basis for glycosylation and deglycosylation of (iso)flavonoids. Journal of Molecular Biology, 392, 1292–1302.

Morishita T, Kojima Y, Maruta T, Nishizawa-Yokoi A, Yabuta Y, Shigeoka S. 2009. Arabidopsis NAC transcription factor, ANAC078, regulates flavonoid biosynthesis under high-light. Plant and Cell Physiology, 50, 2210–2222.

Murata K, Kitano T, Yoshimoto R, Takata R, Ube N, Ueno K, Ueno M, Yabuta Y, Teraishi M, Holland C K, Jander G, Okumoto Y, Mori N, Ishihara A. 2020. Natural variation in the expression and catalytic activity of a naringenin 7-O-methyltransferase influences antifungal defenses in diverse rice cultivars. The Plant Journal, 101, 1103–1117.

Noguchi A, Horikawa M, Fukui Y, Fukuchi-Mizutani M, Iuchi-Okada A, Ishiguro M, Kiso Y, Nakayama T, Ono E. 2009. Local differentiation of sugar donor specificity of flavonoid glycosyltransferase in Lamiales. The Plant Cell, 21, 1556–1572.

Nonaka S, Arai C, Takayama M, Matsukura C, Ezura H. 2017. Efficient increase of ɣ-aminobutyric acid (GABA) content in tomato fruits by targeted mutagenesis. Scientific Reports, 7, 7057.

Pathak S, Regmi S, Nguyen T T, Gupta B, Gautam M, Yong C S, Kim J O, Son Y, Kim J-R, Park M H, Bae Y K, Park S Y, Jeong D, Yook S, Jeong J H. 2018. Polymeric microsphere-facilitated site-specific delivery of quercetin prevents senescence of pancreatic islets in vivo and improves transplantation outcomes in mouse model of diabetes. Acta Biomaterialia, 75, 287–299.

Ren C, Guo Y, Xie L, Zhao Z, Xing M, Cao Y, Liu Y, Lin J, Grierson D, Zhang B, Xu C, Chen K, Li X. 2022. Identification of UDP-rhamnosyltransferases and UDP-galactosyltransferase involved in flavonol glycosylation in Morella rubra. Horticulture Research, 9, uhac138.

Rodríguez-Leal D, Lemmon Z H, Man J, Bartlett M E, Lippman Z B. 2017. Engineering quantitative trait variation for crop improvement by genome editing. Cell, 171, 470–480.e8.

Ruan Y, Zhu X, Shen J, Chen H, Zhou G. 2024. Mechanism of Nicotiflorin in San-Ye-Qing rhizome for anti-inflammatory effect in ulcerative colitis. Phytomedicine, 129, 155564.

Saxena S, Pal L, Naik J, Singh Y, Verma P K, Chattopadhyay D, Pandey A. 2023. The R2R3-MYB-SG7 transcription factor CaMYB39 orchestrates surface phenylpropanoid metabolism and pathogen resistance in chickpea. New Phytologist, 238, 798–816.

Shen H, He X, Poovaiah C R, Wuddineh W A, Ma J, Mann D G J, Wang H, Jackson L, Tang Y, Neal Stewart C, Chen F, Dixon R A. 2012. Functional characterization of the switchgrass (Panicum virgatum) R2R3-MYB transcription factor PvMYB4 for improvement of lignocellulosic feedstocks. New Phytologist, 193, 121–136.

Shi Y, Dai Z, Chen K. 2024. Transcription factors involved in tomato fruit quality improvement. Food Quality and Safety, 8, fyad050.

Tang Y, Zhang L, Sun R, Luo B, Zhou Y, Zhang Y, Liang Y, Xiao B, Wang C. 2023. Pulmonary delivery of mucus-traversing PF127-modified silk fibroin nanoparticles loading with quercetin for lung cancer therapy. Asian Journal of Pharmaceutical Sciences, 18, 100833.

Tohge T, Fernie A R. 2016. Specialized metabolites of the flavonol class mediate root phototropism and growth. Molecular Plant, 9, 1554–1555.

Tohge T, Nishiyama Y, Hirai M Y, Yano M, Nakajima J, Awazuhara M, Inoue E, Takahashi H, Goodenowe D B, Kitayama M, Noji M, Yamazaki M, Saito K. 2005. Functional genomics by integrated analysis of metabolome and transcriptome of Arabidopsis plants over-expressing an MYB transcription factor. The Plant Journal, 42, 218–235.

Ulusoy H G, Sanlier N. 2020. A minireview of quercetin: From its metabolism to possible mechanisms of its biological activities. Critical Reviews in Food Science and Nutrition, 60, 3290–3303.

Wang S, Zhang Z, Li L, Wang H, Zhou H, Chen X, Feng S. 2022. Apple MdMYB306‐like inhibits anthocyanin synthesis by directly interacting with MdMYB17 and MdbHLH33. The Plant Journal, 110, 1021–1034.

Xing M, Cao Y, Grierson D, Sun C, Li X. 2021a. The chemistry, distribution, and metabolic modifications of fruit flavonols. Fruit Research, 1, 1–11.

Xing M, Cao Y, Ren C, Liu Y, Li J, Grierson D, Martin C, Sun C, Chen K, Xu C, Li X. 2021b. Elucidation of myricetin biosynthesis in Morella rubra of the Myricaceae. The Plant Journal, 108, 411–425.

Yoshida K, Ma D, Constabel C P. 2015. The MYB182 protein down-regulates proanthocyanidin and anthocyanin biosynthesis in poplar by repressing both structural and regulatory flavonoid genes. Plant Physiology, 167, 693–710.

Zhang Q, Ge J, Liu X, Wang W, Liu X, Yin X. 2022. Consensus co-expression network analysis identifies AdZAT5 regulating pectin degradation in ripening kiwifruit. Journal of Advanced Research, 40, 59–68.

Zhang S, Zhu H. 2024. Development and prospect of gene-edited fruits and vegetables. Food Quality and Safety, 8, fyad045.

Zhang Y, De Stefano R, Robine M, Butelli E, Bulling K, Hill L, Rejzek M, Martin C, Schoonbeek H J. 2015. Different reactive oxygen species scavenging properties of flavonoids determine their abilities to extend the shelf life of tomato. Plant Physiology, 169, 1568–1583.

Zheng W, Wang H, Wang X, Li X, Hu J, Zi X, Zhou Y, Pan D, Fu Y. 2024. Kaempferol 3-O-rutinoside, a flavone derived from Tetrastigma hemsleyanum Diels et Gilg, reduces body temperature through accelerating the elimination of IL-6 and TNF-α in a mouse fever model. Molecules, 29, 1641.