Adang M J, Crickmore N, Jurat-Fuentes J L. 2014. Diversity of Bacillus thuringiensis crystal toxins and mechanism of action. Advances in Insect Physiology, 47, 39–87.

Adegawa S, Nakama Y, Endo H, Shinkawa N, Kikuta S, Sato R. 2017. The domain II loops of Bacillus thuringiensis Cry1Aa form an overlapping interaction site for two Bombyx mori larvae functional receptors, ABC transporter C2 and cadherin-like receptor. Biochimica et Biophysica Acta, 1865, 220–231.

Aurade R M, Jayalakshmi S K, Sreeramulu K. 2010. P-glycoprotein ATPase from the resistant pest, Helicoverpa armigera: Purification, characterization and effect of various insecticides on its transport function. Biochimica et Biophysica Acta, 1798, 1135–1143.

Bravo A, Likitvivatanavong S, Gill S S, Soberón M. 2011. Bacillus thuringiensis: A story of a successful bioinsecticide. Insect Biochemistry and Molecular Biology, 41, 423–431.

Chen L P, Wang P, Sun Y J, Wu Y J. 2016. Direct interaction of avermectin with epidermal growth factor receptor mediates the penetration resistance in Drosophila larvae. Open Biology, 6, 150231.

Dean M, Moitra K, Allikmets R. 2022. The human ATP-binding cassette (ABC) transporter superfamily. Human Mutation, 43, 1162–1182.

Endo H. 2022. Molecular and kinetic models for pore formation of Bacillus thuringiensis Cry toxin. Toxins, 14, 433.

Epis S, Porretta D, Mastrantonio V, Urbanelli S, Sassera D, De Marco L, Mereghetti V, Montagna M, Ricci I, Favia G, Bandi C. 2014. Temporal dynamics of the ABC transporter response to insecticide treatment: insights from the malaria vector Anopheles stephensi. Scientific Reports, 4, 7435.

Figueira-Mansur J, Ferreira-Pereira A, Mansur J F, Franco T A, Alvarenga E S L, Sorgine M H F, Neves B C, Melo A C A, Leal W S, Masuda H, Moreira M F. 2013. Silencing of P-glycoprotein increases mortality in temephos-treated Aedes aegypti larvae. Insect Molecular Biology, 22, 648–658.

Furlong M J, Wright D J, Dosdall L M. 2013. Diamondback moth ecology and management: problems, progress, and prospects. Annual Review of Entomology, 58, 517–541.

Gong L, Kang S, Zhou J, Sun D, Guo L, Qin J, Zhu L, Bai Y, Ye F, Akami M, Wu Q, Wang S, Xu B, Yang Z, Bravo A, Soberon M, Guo Z, Wen L, Zhang Y. 2020. Reduced expression of a novel midgut trypsin gene involved in protoxin activation correlates with Cry1Ac resistance in a laboratory-selected strain of Plutella xylostella (L.). Toxins, 12, 15.

Gott R C, Kunkel G R, Zobel E S, Lovett B R, Hawthorne D J. 2017. Implicating ABC transporters in insecticide resistance: Research strategies and a decision framework. Journal of Economic Entomology, 110, 667–677.

Güney G, Cedden D, Hänniger S, Heckel D G, Coutu C, Hegedus D D, Mutlu D A, Suludere Z, Sezen K, Güney E, Toprak U. 2021. Silencing of an ABC transporter, but not a cadherin, decreases the susceptibility of Colorado potato beetle larvae to Bacillus thuringiensis ssp. tenebrionis Cry3Aa toxin. Archives of Insect Biochemistry and Physiology, 108, e21834.

Guo L, Cheng Z, Qin J, Sun D, Wang S, Wu Q, Crickmore N, Zhou X, Bravo A, Soberón M, Guo Z, Zhang Y. 2022. MAPK-mediated transcription factor GATAd contributes to Cry1Ac resistance in diamondback moth by reducing PxmALP expression. PLoS Genetics, 18, e1010037.

Guo Z, Guo L, Bai Y, Kang S, Sun D, Qin J, Ye F, Wang S, Wu Q, Xie W, Yang X, Crickmore N, Zhou X, Zhang Y. 2023. Retrotransposon-mediated evolutionary rewiring of a pathogen response orchestrates a resistance phenotype in an insect host. Proceedings of the National Academy of Sciences of the United States of America, 120, e2300439120.

Guo Z, Gong L, Kang S, Zhou J, Sun D, Qin J, Guo L, Zhu L, Bai Y, Bravo A, Soberón M, Zhang Y. 2020a. Comprehensive analysis of Cry1Ac protoxin activation mediated by midgut proteases in susceptible and resistant Plutella xylostella (L.). Pesticide Biochemistry and Physiology, 163, 23–30.

Guo Z, Guo L, Qin J, Ye F, Sun D, Wu Q, Wang S, Crickmore N, Zhou X, Bravo A, Soberón M, Zhang Y. 2022. A single transcription factor facilitates an insect host combating Bacillus thuringiensis infection while maintaining fitness. Nature Communications, 13, 6024.

Guo Z, Kang S, Chen D, Wu Q, Wang S, Xie W, Zhu X, Baxter S W, Zhou X, Jurat-Fuentes J L, Zhang Y. 2015a. MAPK signaling pathway alters expression of midgut ALP and ABCC genes and causes resistance to Bacillus thuringiensis Cry1Ac toxin in diamondback moth. PLoS Genetics, 11, e1005124.

Guo Z, Kang S, Sun D, Gong L, Zhou J, Qin J, Guo L, Zhu L, Bai Y, Ye F, Wu Q, Wang S, Crickmore N, Zhou X, Zhang Y. 2020b. MAPK-dependent hormonal signaling plasticity contributes to overcoming Bacillus thuringiensis toxin action in an insect host. Nature Communications, 11, 3003.

Guo Z, Kang S, Wu Q, Wang S, Crickmore N, Zhou X, Bravo A, Soberón M, Zhang Y. 2021. The regulation landscape of MAPK signaling cascade for thwarting Bacillus thuringiensis infection in an insect host. PLoS Pathogens, 17, e1009917.

Guo Z, Kang S, Zhu X, Wu Q, Wang S, Xie W, Zhang Y. 2015b. The midgut cadherin-like gene is not associated with resistance to Bacillus thuringiensis toxin Cry1Ac in Plutella xylostella (L.). Journal of Invertebrate Pathology, 126, 21–30.

Guo Z, Kang S, Zhu X, Xia J, Wu Q, Wang S, Xie W, Zhang Y. 2015c. Down-regulation of a novel ABC transporter gene (Pxwhite) is associated with Cry1Ac resistance in the diamondback moth, Plutella xylostella (L.). Insect Biochemistry and Molecular Biology, 59, 30–40.

Guo Z, Sun D, Kang S, Zhou J, Gong L, Qin J, Guo L, Zhu L, Bai Y, Luo L, Zhang Y. 2019. CRISPR/Cas9-mediated knockout of both the PxABCC2 and PxABCC3 genes confers high-level resistance to Bacillus thuringiensis Cry1Ac toxin in the diamondback moth, Plutella xylostella (L.). Insect Biochemistry and Molecular Biology, 107, 31–38.

Hou W, Jiang C, Zhou X, Qian K, Wang L, Shen Y, Zhao Y. 2016. Increased expression of P-glycoprotein is associated with chlorpyrifos resistance in the German cockroach (Blattodea: Blattellidae). Journal of Economic Entomology, 109, 2500–2505.

Igboeli O O, Fast M D, Heumann J, Burka J F. 2012. Role of P-glycoprotein in emamectin benzoate (SLICE®) resistance in sea lice, Lepeophtheirus salmonis. Aquaculture, 344–349, 40–47.

ISAAA (International Service for the Acquisition of Agri-biotech Applications). 2019. Global Status of Commercialized Biotech/GM Crops in 2019. Brief 55. ISAAA, Ithaca, NY, USA.

Jurat-Fuentes J L, Crickmore N. 2017. Specificity determinants for Cry insecticidal proteins: Insights from their mode of action. Journal of Invertebrate Pathology, 142, 5–10.

Jurat-Fuentes J L, Heckel D G, Ferré J. 2021. Mechanisms of resistance to insecticidal proteins from Bacillus thuringiensis. Annual Review of Entomology, 66, 121–140.

Kang S, Sun D, Qin J, Guo L, Zhu L, Bai Y, Wu Q, Wang S, Zhou X, Guo Z, Zhang Y. 2022a. Fused: a promising molecular target for an RNAi-based strategy to manage Bt resistance in Plutella xylostella (L.). Journal of Pest Science, 95, 101–114.

Kang S, Zhu X, Wu Q, Wang S, Crickmore N, Zhang Y, Guo Z. 2022b. Critical analysis of multi-omic data from a strain of Plutella xylostella resistant to Bacillus thuringiensis Cry1Ac toxin. Journal of Agricultural and Food Chemistry, 70, 11419–11428.

Li Q, Jin M, Yu S, Cheng Y, Shan Y, Wang P, Yuan H, Xiao Y. 2022. Knockout of the ABCB1 gene increases susceptibility to emamectin benzoate, beta-cypermethrin and chlorantraniliprole in Spodoptera frugiperda. Insects, 13, 137.

Li Z, Feng X, Liu S S, You M, Furlong M J. 2016. Biology, ecology, and management of the diamondback moth in China. Annual Review of Entomology, 61, 277–296.

Liu L, Chen Z, Yang Y, Xiao Y, Liu C, Ma Y, Soberón M, Bravo A, Yang Y, Liu K. 2018. A single amino acid polymorphism in ABCC2 loop 1 is responsible for differential toxicity of Bacillus thuringiensis Cry1Ac toxin in different Spodoptera (Noctuidae) species. Insect Biochemistry and Molecular Biology, 100, 59–65.

Merzendorfer H. 2014. ABC transporters and their role in protecting insects from pesticides and their metabolites. Advances in Insect Physiology, 46, 1–72.

Niu X, Kassa A, Hasler J, Griffin S, Perez-Ortega C, Procyk L, Zhang J, Kapka-Kitzman D M, Nelson M E, Lu A. 2020. Functional validation of DvABCB1 as a receptor of Cry3 toxins in western corn rootworm, Diabrotica virgifera virgifera. Scientific Reports, 10, 15830.

Pauchet Y, Bretschneider A, Augustin S, Heckel D G. 2016. A P-glycoprotein is linked to resistance to the Bacillus thuringiensis Cry3Aa toxin in a leaf beetle. Toxins, 8, 362.

Peterson B, Bezuidenhout C C, Van den Berg J. 2017. An overview of mechanisms of Cry toxin resistance in lepidopteran insects. Journal of Economic Entomology, 110, 362–377.

Pinos D, Andrés-Garrido A, Ferré J, Hernández-Martínez P. 2021. Response mechanisms of invertebrates to Bacillus thuringiensis and its pesticidal proteins. Microbiology and Molecular Biology Reviews, 85, e00007-20.

Pohl P C, Klafke G M, Carvalho D D, Martins J R, Daffre S, Vaz I S, Masuda A. 2011. ABC transporter efflux pumps: A defense mechanism against ivermectin in Rhipicephalus (Boophilus) microplus. International Journal for Parasitology, 41, 1323–1333.

Porretta D, Gargani M, Bellini R, Medici A, Punelli F, Urbanelli S. 2008. Defence mechanisms against insecticides temephos and diflubenzuron in the mosquito Aedes caspius: the P-glycoprotein efflux pumps. Medical and Veterinary Entomology, 22, 48–54.

Qin J, Guo L, Ye F, Kang S, Sun D, Zhu L, Bai Y, Cheng Z, Xu L, Ouyang C, Xiao L, Wang S, Wu Q, Zhou X, Crickmore N, Zhou X, Guo Z, Zhang Y. 2021a. MAPK-activated transcription factor PxJun suppresses PxABCB1 expression and confers resistance to Bacillus thuringiensis Cry1Ac toxin in Plutella xylostella (L.). Applied and Environmental Microbiology, 87, e00466-21.

Qin J, Ye F, Xu L, Zhou X, Crickmore N, Zhou X, Zhang Y, Guo Z. 2021b. A cis-acting mutation in the PxABCG1 promoter is associated with Cry1Ac resistance in Plutella xylostella (L.). International Journal of Molecular Sciences, 22, 6106.

Rees D, Johnson E, Lewinson O. 2009. ABC transporters: The power to change. Nature Reviews Molecular Cell Biology, 10, 218–227.

Sato R, Adegawa S, Li X, Tanaka S, Endo H. 2019. Function and role of ATP-binding cassette transporters as receptors for 3D-Cry toxins. Toxins, 11, 124.

Silva R, Vilas-Boas V, Carmo H, Dinis-Oliveira R J, Carvalho F, Bastos M L, Remião F. 2015. Modulation of P-glycoprotein efflux pump: Induction and activation as a therapeutic strategy. Pharmacology & Therapeutics, 149, 1–123.

Sun D, Guo Z, Liu Y, Zhang Y. 2017. Progress and prospects of CRISPR/Cas systems in insects and other arthropods. Frontiers in Physiology, 8, 608.

Sun D, Zhu L, Guo L, Wang S, Wu Q, Crickmore N, Zhou X, Bravo A, Soberón M, Guo Z, Zhang Y. 2022. A versatile contribution of both aminopeptidases N and ABC transporters to Bt Cry1Ac toxicity in the diamondback moth. BMC Biology, 20, 33.

Sun H, Pu J, Chen F, Wang J, Han Z. 2017. Multiple ATP-binding cassette transporters are involved in insecticide resistance in the small brown planthopper, Laodelphax striatellus. Insect Molecular Biology, 26, 343–355.

Tabashnik B E, Carrière Y. 2017. Surge in insect resistance to transgenic crops and prospects for sustainability. Nature Biotechnology, 35, 926–935.

Tanaka S, Endo H, Adegawa S, Iizuka A, Imamura K, Kikuta S, Sato R. 2017. Bombyx mori ABC transporter C2 structures responsible for the receptor function of Bacillus thuringiensis Cry1Aa toxin. Insect Biochemistry and Molecular Biology, 91, 44–54.

Tanaka S, Miyamoto K, Noda H, Endo H, Kikuta S, Sato R. 2016. Single amino acid insertions in extracellular loop 2 of Bombyx mori ABCC2 disrupt its receptor function for Bacillus thuringiensis Cry1Ab and Cry1Ac but not Cry1Aa toxins. Peptides, 78, 99–108.

Tian L, Yang J, Hou W, Xu B, Xie W, Wang S, Zhang Y, Zhou X, Wu Q. 2013. Molecular cloning and characterization of a P-glycoprotein from the diamondback moth, Plutella xylostella (Lepidoptera: Plutellidae). International Journal of Molecular Sciences, 14, 22891–22905.

Wu C, Chakrabarty S, Jin M, Liu K, Xiao Y. 2019. Insect ATP-binding cassette (ABC) transporters: roles in xenobiotic detoxification and Bt insecticidal activity. International Journal of Molecular Sciences, 20, 2829.

Xiang M, Zhang L, Lu Y, Tang Q, Liang P, Shi X, Song D, Gao X. 2017. A P-glycoprotein gene serves as a component of the protective mechanisms against 2-tridecanone and abamectin in Helicoverpa armigera. Gene, 627, 63–71.

Xiao Y, Liu K, Zhang D, Gong L, He F, Soberón M, Bravo A, Tabashnik B E, Wu K. 2016. Resistance to Bacillus thuringiensis mediated by an ABC transporter mutation increases susceptibility to toxins from other bacteria in an invasive insect. PLoS Pathogens, 12, e1005450.

Xiao Y, Wu K. 2019. Recent progress on the interaction between insects and Bacillus thuringiensis crops. Philosophical Transactions of the Royal Society (B: Biological Sciences), 374, 20180316.

Xu L, Qin J, Fu W, Wang S, Wu Q, Zhou X, Crickmore N, Guo Z, Zhang Y. 2022. MAP4K4 controlled transcription factor POUM1 regulates PxABCG1 expression influencing Cry1Ac resistance in Plutella xylostella (L.). Pesticide Biochemistry and Physiology, 182, 105053.

Xu Z, Shi L, Peng J, Shen G, Wei P, Wu Q, He L. 2016. Analysis of the relationship between P-glycoprotein and abamectin resistance in Tetranychus cinnabarinus (Boisduval). Pesticide Biochemistry and Physiology, 129, 75–82.

Zhou J, Guo Z, Kang S, Qin J, Gong L, Sun D, Guo L, Zhu L, Bai Y, Zhang Z, Zhou X, Zhang Y. 2020. Reduced expression of the P-glycoprotein gene PxABCB1 is linked to resistance to Bacillus thuringiensis Cry1Ac toxin in Plutella xylostella (L.). Pest Management Science, 76, 712–720.

Zuo Y Y, Huang J L, Wang J, Feng Y, Han T T, Wu Y D, Yang Y H. 2018. Knockout of a P-glycoprotein gene increases susceptibility to abamectin and emamectin benzoate in Spodoptera exigua. Insect Molecular Biology, 27, 36–45.