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Journal of Integrative Agriculture  2021, Vol. 20 Issue (1): 24-34    DOI: 10.1016/S2095-3119(20)63195-1
Special Issue: 动物营养合辑Animal Nutrition
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Alginate oligosaccharides preparation, biological activities and their application in livestock and poultry 
LIU Ming1, 2, 3, LIU Lei1, ZHANG Hong-fu1, YI Bao1, Nadia Everaert2 
1 State Key Laboratory of Animal Nutrition, Institute of Animal Sciences, Chinese Academy of Agricultural Sciences, Beijing 100193, P.R.China
2 Precision Livestock and Nutrition Unit, Gembloux Agro-BioTech, University of Liège, Gembloux 5030, Belgium
3 Beijing China-Agri Hong Ke Bio-Technology Co., Ltd., Beijing 102206, P.R.China
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Abstract  Alginate oligosaccharides (AOS), belonging to the class of functional marine oligosaccharides, are low-molecular polymers linked by β-1,4-mannuronic acid (M) and α-1,4-guluronic acid (G), which could be classically obtained by enzymatic hydrolysis of alginate. With low viscosity and good water solubility, as well as anti-oxidant, immune regulation, anti-bacterial and anti-inflammatory activities, AOS have been widely used in medical science and functional food, green agriculture and other fields. As new bio-feed additives, AOS have broad potential applications in animal husbandry. In this review, the sources of alginate, chemical structure and preparation methods of AOS, and their biological activities and application in livestock and poultry are summarized. We expect this review could contribute to lay a foundation of application and further research for AOS in livestock and poultry.
Keywords:  alginate oligosaccharides        preparation        anti-oxidant        immune        livestock and poultry  
Received: 24 June 2019   Accepted:
Fund: Fundings were provided by the National Key R&D Program of China (2016YFD0500501), the National Natural Science Foundation of China (31772641) and the Basic Science and Research Funding of Institute of Animal Sciences of Chinese Academy of Agricultural Sciences, China (2018-YWF-YB-11).
Corresponding Authors:  Correspondence YI Bao, Tel: +86-10-62816013, Fax: +86-10-62818910, E-mail:   
About author:  LIU Ming, E-mail:;

Cite this article: 

LIU Ming, LIU Lei, ZHANG Hong-fu, YI Bao, Nadia EVERAERT. 2021. Alginate oligosaccharides preparation, biological activities and their application in livestock and poultry . Journal of Integrative Agriculture, 20(1): 24-34.

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