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Special Issue:
动物营养合辑Animal Nutrition
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| Alginate oligosaccharides preparation, biological activities and their application in livestock and poultry |
LIU Ming1, 2, 3, LIU Lei1, ZHANG Hong-fu1, YI Bao1, Nadia Everaert2 |
1 State Key Laboratory of Animal Nutrition, Institute of Animal Sciences, Chinese Academy of Agricultural Sciences, Beijing 100193, P.R.China
2 Precision Livestock and Nutrition Unit, Gembloux Agro-BioTech, University of Liège, Gembloux 5030, Belgium
3 Beijing China-Agri Hong Ke Bio-Technology Co., Ltd., Beijing 102206, P.R.China |
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摘要
褐藻寡糖是一种功能性海洋寡糖，由褐藻胶经酶解得到，由β-1，4-甘露糖醛酸（M）和α-1，4-古洛糖醛酸（G）链接起来的不规则低分子聚合物。褐藻寡糖粘度较低、水溶性强；此外，它还具有抗氧化、免疫调节、抗细菌和炎症等多种生物学活性，在医学科学、功能食品、绿色农业等领域有着广泛的应用。虽然我们对褐藻寡糖的研究相对缺乏，但它作为一种新型生物饲料添加剂应用于畜牧业生产中，前景广阔。本文综述了褐藻胶的来源、褐藻寡糖的化学组成、制备方法与生物学活性，以及在畜禽上的应用，为后续褐藻寡糖的深入研究和未来在产业上的应用奠定基础。
Abstract Alginate oligosaccharides (AOS), belonging to the class of functional marine oligosaccharides, are low-molecular polymers linked by β-1,4-mannuronic acid (M) and α-1,4-guluronic acid (G), which could be classically obtained by enzymatic hydrolysis of alginate. With low viscosity and good water solubility, as well as anti-oxidant, immune regulation, anti-bacterial and anti-inflammatory activities, AOS have been widely used in medical science and functional food, green agriculture and other fields. As new bio-feed additives, AOS have broad potential applications in animal husbandry. In this review, the sources of alginate, chemical structure and preparation methods of AOS, and their biological activities and application in livestock and poultry are summarized. We expect this review could contribute to lay a foundation of application and further research for AOS in livestock and poultry.
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Received: 24 June 2019
Accepted:
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| Fund: Fundings were provided by the National Key R&D Program of China (2016YFD0500501), the National Natural Science Foundation of China (31772641) and the Basic Science and Research Funding of Institute of Animal Sciences of Chinese Academy of Agricultural Sciences, China (2018-YWF-YB-11). |
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Corresponding Authors:
Correspondence YI Bao, Tel: +86-10-62816013, Fax: +86-10-62818910, E-mail: yibao@caas.cn
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| About author: LIU Ming, E-mail: paul1009@126.com; |
Cite this article:
LIU Ming, LIU Lei, ZHANG Hong-fu, YI Bao, Nadia EVERAERT.
2021.
Alginate oligosaccharides preparation, biological activities and their application in livestock and poultry . Journal of Integrative Agriculture, 20(1): 24-34.
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Aida T M, Yamagata T, Watanabe M, Smith Jr R L. 2010. Depolymerization of sodium alginate under hydrothermal conditions. Carbohydrate Polymers, 80, 296–302.
Akiyama H, Endo T, Nakakita R, Murata K, Yonemoto Y, Okayama K. 1992. Effect of depolymerized alginates on the growth of bifidobacteria. Bioscience Biotechnology & Biochemistry, 56, 355–356.
Chand?? A N P, Matsuhiro B, Vásquez A E. 2001. Alginic acids in Lessonia trabeculata: Characterization by formic acid hydrolysis and FT-IR spectroscopy. Carbohydrate Polymers, 46, 81–87.
Chen J, Hu Y, Zhang L, Wang Y, Wang S, Zhang Y, Guo H, Ji D, Wang Y. 2017. Alginate oligosaccharide DP5 exhibits antitumor effects in osteosarcoma patients following surgery. Frontiers in Pharmacology, 8, 623.
Falkeborg M, Cheong L Z, Gianfico C, Sztukiel K M, Kristensen K, Glasius M, Xu X, Guo Z. 2014. Alginate oligosaccharides: Enzymatic preparation and antioxidant property evaluation. Food Chemistry, 164, 185–194.
Fang W, Bi D, Zheng R, Cai N, Xu H, Zhou R, Lu J, Wan M, Xu X. 2017. Identification and activation of TLR4-mediated signalling pathways by alginate-derived guluronate oligosaccharide in RAW264.7 macrophages. Scientific Reports, 7, 1663.
Gacesa P. 2009. Enzymic degradation of alginates. Journal of the Electrochemical Society, 24, 545–552.
Guo J J, Ma L L, Shi H T, Zhu J B, Wu J, Ding Z W, An Y, Zou Y Z, Ge J B. 2016. Alginate oligosaccharide prevents acute doxorubicin cardiotoxicity by suppressing oxidative stress and endoplasmic reticulum-mediated apoptosis. Marine Drugs, 14, 231.
Haug A, Larsen B, Smidsrod O. 1966. A study of the constitution of alginic acid by partial acid hydrolysis. In: Proceedings of the Fifth International Seaweed Symposium. Halifax, Canada. pp. 271–277.
Holtan S, Zhang Q, Strand W I, Braek G S. 2006. Characterization of the hydrolysis mechanism of polyalternating alginate in weak acid and assignment of the resulting MG-oligosaccharides by NMR spectroscopy and ESI-mass spectrometry. Biomacromolecules, 7, 2108–2121.
Horn S J, Østgaard K. 2001. Alginate lyase activity and acidogenesis during fermentation of Laminaria hyperborea. Journal of Applied Phycology, 13, 143–152.
Hu T, Li C, Zhao X, Li G, Yu G, Guan H. 2013. Preparation and characterization of guluronic acid oligosaccharides degraded by a rapid microwave irradiation method. Carbohydrate Research, 373, 53–58.
Hu X, Jiang X, Gong J, Hwang H, Yan L, Guan H. 2005. Antibacterial activity of lyase-depolymerized products of alginate. Journal of Applied Phycology, 17, 57–60.
Hu X, Jiang X, Hwang H, Liu S, Guan H. 2004. Antitumour activities of alginate-derived oligosaccharides and their sulphated substitution derivatives. European Journal of Phycology, 39, 67–71.
Iwasaki K, Matsubara Y. 2000. Purification of alginate oligosaccharides with root growth-promoting activity toward lettuce. Bioscience Biotechnology & Biochemistry, 64, 1067–1070.
Jacobsen C, Sorensen A M, Holdt S L, Akoh C C, Hermund D B. 2019. Source, extraction, characterization, and applications of novel antioxidants from seaweed. Annual Review of Food Science and Technology, 10, 541–568.
Johnson F A, Craig D Q, Mercer A D. 1997. Characterization of the block structure and molecular weight of sodium alginates. Journal of Pharmacy and Pharmacology, 49, 639–643.
Kang H K, Seo C H, Park Y. 2015. The effects of marine carbohydrates and glycosylated compounds on human health. International Journal of Molecular Sciences, 16, 6018–6056.
Kawada A, Hiura N, Shiraiwa M, Tajima S, Hiruma M, Hara K, Ishibashi A, Takahara H. 1997. Stimulation of human keratinocyte growth by alginate oligosaccharides, a possible co-factor for epidermal growth factor in cell culture. Febs Letters, 408, 43–46.
Kawada A, Hiura N, Tajima S, Takahara H. 1999. Alginate oligosaccharides stimulate VEGF-mediated growth and migration of human endothelial cells. Archives of Dermatological Research, 291, 542–547.
Lee K Y, Mooney D J. 2012. Alginate: Properties and biomedical applications. Progress in Polymer Science, 37, 106–126.
Li X X, Xu A H, Xie H G, Yu W T, Xie W Y. 2010. Preparation of low molecular weight alginate by hydrogen peroxide depolymerization for tissue engineering. Carbohydrate Polymers, 79, 660–664.
Li H B, Xie C, Ding C, Huang J, Qiu X H, Lin L. 2015. Alginate oligosaccharides chemical oxidation preparation and purification technology and the physical and chemical properties analysis. Oceanologia et Limnologia Sinica, 46, 915–921.
Lu J, Yang H, Hao J, Wu C, Liu L, Xu N, Linhardt R J, Zhang Z. 2015. Impact of hydrolysis conditions on the detection of mannuronic to guluronic acid ratio in alginate and its derivatives. Carbohydrate Polymers, 122, 180–188.
Matsushima K, Minoshima H. 2005. Decomposition reaction of alginic acid using subcritical and supercritical water. Industrial & Engineering Chemistry Research, 44, 9626–9630.
Nagasawa N, Mitomo H, Yoshii F, Kume T. 2000. Radiation-induced degradation of sodium alginate. Polymer Degradation & Stability, 69, 279–285.
Natsume M, Kamo Y, Hirayama M, Adachi T. 1994. Isolation and characterization of alginate-derived oligosaccharides with root growth-promoting activities. Carbohydrate Research, 258, 187–197.
Niemelä K, Sjöström E. 1985. Alkaline degradation of alginates to carboxylic acids. Carbohydrate Research, 144, 241–249.
Nishide E, Tsukayarna K, Uchida N, Nisizawa K. 1984. Isolation of water-soluble alginate from brown algae. Hydrobiologia, 116–117, 557–562.
Osawa T, Matsubara Y, Muramatsu T, Kimura M, Kakuta Y. 2005. Crystal structure of the alginate (poly α-I-guluronate) lyase from Corynebacterium sp. at 1.2Å resolution. Journal of Molecular Biology, 345, 1111–1118.
Otterlei M, Ostgaard K, Skjåk-Braek G, Smidsrød O, Soon-Shiong P, Espevik T. 1991. Induction of cytokine production from human monocytes stimulated with alginate. Journal of Immunotherapy, 10, 286.
Otterlei M, Sundan A, Skjåk-Braek G, Ryan L, Smidsrød O, Espevik T. 1993. Similar mechanisms of action of defined polysaccharides and lipopolysaccharides: Characterization of binding and tumor necrosis factor alpha induction. Infection & Immunity, 61, 1917–1925.
Sen M. 2011. Effects of molecular weight and ratio of guluronic acid to mannuronic acid on the antioxidant properties of sodium alginate fractions prepared by radiation-induced degradation. Applied Radiation and Isotopes, 69, 126–129.
Smidsrød O, Haug A, Larsen B, Gronowitz S, Hoffman R A, Westerdahl A. 1965. The effect of divalent metals on the properties of alginate solutions. I. Calcium ions. Acta Chemica Scandinavica, 19, 329–340.
Suzuki H, Suzuki K I, Inoue A, Ojima T. 2006. A novel oligoalginate lyase from abalone, Haliotis discus hannai, that releases disaccharide from alginate polymer in an exolytic manner. Carbohydrate Research, 341, 1809–1819.
Svanem B I, Strand W I, Ertesvag H, Skjåk-Braek G, Hartmann M, Barbeyron T, Valla S. 2001. The catalytic activities of the bifunctional Azotobacter vinelandii mannuronan C-5-epimerase and alginate lyase AlgE7 probably originate from the same active site in the enzyme. Journal of Biological Chemistry, 276, 31542–31550.
Tomoda Y, Umemura K, Adachi T. 1994. Promotion of barley root elongation under hypoxic conditions by alginate lyase-lysate (A.L.L.). Journal of the Agricultural Chemical Society of Japan, 58, 202–203.
Tøndervik A, Sletta H, Klinkenberg G, Emanuel C, Powell L C, Pritchard M F, Khan S, Craine K M, Onsøyen E, Rye P D. 2014. Alginate oligosaccharides inhibit fungal cell growth and potentiate the activity of antifungals against Candida and Aspergillus spp. PLoS ONE, 9, e112518.
Tusi S K, Khalaj L, Ashabi G, Kiaei M, Khodagholi F. 2011. Alginate oligosaccharide protects against endoplasmic reticulum- and mitochondrial-mediated apoptotic cell death and oxidative stress. Biomaterials, 32, 5438–5458.
Ueno M, Hiroki T, Takeshita S, Jiang Z, Kim D, Yamaguchi K, Oda T. 2012. Comparative study on antioxidative and macrophage-stimulating activities of polyguluronic acid (PG) and polymannuronic acid (PM) prepared from alginate. Carbohydrate Research, 352, 88–93.
Uno T, Hattori M, Yoshida T. 2006. Oral administration of alginic acid oligosaccharide suppresses IgE production and inhibits the induction of oral tolerance. Bioscience, Biotechnology, and Biochemistry, 70, 3054–3057.
Wan J, Zhang J, Chen D, Yu B, He J. 2017. Effects of alginate oligosaccharide on the growth performance, antioxidant capacity and intestinal digestion-absorption function in weaned pigs. Animal Feed Science & Technology, 234, 118–127.
Wan J, Zhang J, Chen D, Yu B, He J. 2018a. Alginate oligosaccharide alleviates enterotoxigenic Escherichia coli-induced intestinal mucosal disruption in weaned pigs. Food & Function, 9, 6401–6413.
Wan J, Zhang J, Chen D, Yu B, Huang Z, Mao X, Ping Z, Yu J, He J. 2018b. Alginate oligosaccharide enhances intestinal integrity of weaned pigs through altering intestinal inflammatory responses and antioxidant status. Rsc Advances, 8, 13482–13492.
Wan J, Zhang J, Chen D, Yu B, Mao X, Zheng P, Yu J, Luo J, He J. 2018c. Alginate oligosaccharide-induced intestinal morphology, barrier function and epithelium apoptosis modifications have beneficial effects on the growth performance of weaned pigs. Journal of Animal Science & Biotechnology, 9, 937–948.
Wan L S, Heng P W, Chan L W. 1992. Drug encapsulation in alginate microspheres by emulsification. Journal of Microencapsulation, 9, 309–316.
Wang P, Jiang X, Jiang Y, Hu X, Mou H, Li M, Guan H. 2007. In vitro antioxidative activities of three marine oligosaccharides. Natural Product Research, 21, 646–654.
Wang Y, Han F, Hu B, Li J, Yu W. 2006. In vivo prebiotic properties of alginate oligosaccharides prepared through enzymatic hydrolysis of alginate. Nutrition Research, 26, 597–603.
Wong T Y, Preston L A, Schiller N L. 2000. Alginate lyase: Review of major sources and enzyme characteristics, structure-function analysis, biological roles, and applications. Annual Review of Microbiology, 54, 289–340.
Wright C J. 2013. The effect of alginate oligosaccharides on the mechanical properties of Gram-negative biofilms. Biofouling, 29, 413–421.
Xu X, Wu X, Wang Q, Cai N, Zhang H, Jiang Z, Wan M, Oda T. 2014. Immunomodulatory effects of elginate oligosaccharides on murine macrophage RAW264.7 cells and their structure-activity relationships. Journal of Agricultural & Food Chemistry, 62, 3168–3176.
Yamamoto Y, Kurachi M, Yamaguchi K, Oda T. 2007a. Induction of multiple cytokine secretion from RAW264.7 cells by alginate oligosaccharides. Bioscience, Biotechnology, and Biochemistry, 71, 238–241.
Yamamoto Y, Kurachi M, Yamaguchi K, Oda T. 2007b. Stimulation of multiple cytokine production in mice by alginate oligosaccharides following intraperitoneal administration. Carbohydrate Research, 342, 1133–1137.
Yamasaki Y, Yokose T, Nishikawa T, Kim D, Jiang Z, Yamaguchi K, Oda T. 2012. Effects of alginate oligosaccharide mixtures on the growth and fatty acid composition of the green alga Chlamydomonas reinhardtii. Journal of Bioscience and Bioengineering, 113, 112–116.
Yan G L, Guo Y M, Yuan J M, Liu D, Zhang B K. 2011. Sodium alginate oligosaccharides from brown algae inhibit Salmonella enteritidis colonization in broiler chickens. Poultry Science, 90, 1441–1448.
Yanaki T, Nishii K, Tabata K, Kojima T. 2010. Ultrasonic degradation of Schizophyllum commune polysaccharide in dilute aqueous solution. Journal of Applied Polymer Science, 28, 873–878.
Yang Y, Ma Z, Yang G, Wan J, Li G, Du L, Lu P. 2017. Alginate oligosaccharide indirectly affects toll-like receptor signaling via the inhibition of microRNA-29b in aneurysm patients after endovascular aortic repair. Drug Design Development & Therapy, 11, 2565–2579.
Yang Z, Li J P, Guan H S. 2004. Preparation and characterization of oligomannuronates from alginate degraded by hydrogen peroxide. Carbohydrate Polymers, 58, 115–121.
Yoshida T, Hirano A, Wada H, Takahashi K, Hattori M. 2004. Alginic acid oligosaccharide suppresses Th2 development and IgE production by inducing IL-12 production. International Archives of Allergy and Immunology, 133, 239–247.
Yoshiko I, Xu X, Tadashi T, Tatsuya O, Tsuyoshi M. 2003. Enzymatically depolymerized alginate oligomers that cause cytotoxic cytokine production in human mononuclear cells. Journal of the Agricultural Chemical Society of Japan, 67, 258–263.
Zhang L, Shi H T, Li Y Q, Peng Y S, Wu J. 2018. Effects of dietary supplementation of alginate oligosaccharide on growth performance, antioxidant capacity and intestinal digestion-absorption function of weaning pigs. China Feed, 14, 56–61. (in Chinese)
Zhang Y, Yin H, Zhao X, Wang W, Du Y, He A, Sun K. 2014. The promoting effects of alginate oligosaccharides on root development in Oryza sativa L. mediated by auxin signaling. Carbohydrate Polymers, 113, 446–454.
Zhang Z, Yu G, Guan H, Zhao X, Du Y, Jiang X. 2004. Preparation and structure elucidation of alginate oligosaccharides degraded by alginate lyase from Vibro sp. 510. Carbohydrate Research, 339, 1475–1481.
Zhao X, Li B, Sun L. 2012. Effect of molecular weight on the antioxidant property of low molecular weight alginate from Laminaria japonica. Journal of Applied Phycology, 24, 295–300.
Zhou R, Shi X, Gao Y, Cai N, Jiang Z, Xu X. 2015. Anti-inflammatory activity of guluronate oligosaccharides obtained by oxidative degradation from alginate in lipopolysaccharide-activated murine macrophage RAW 264.7 cells. Journal of Agricultural and Food Chemistry, 63, 160–168.
Zhu B, Chen M, Yin H, Du Y, Ning L. 2016. Enzymatic hydrolysis of alginate to produce oligosaccharides by a new purified endo-type alginate lyase. Marine Drugs, 14, 108.
Zhu B, Yin H. 2015. Alginate lyase: Review of major sources and classification, properties, structure-function analysis and applications. Bioengineered Bugs, 6, 125–131.
Zhu W, Li D, Wang J, Wu H, Xia X, Bi W, Guan H, Zhang L. 2015. Effects of polymannuronate on performance, antioxidant capacity, immune status, cecal microflora, and volatile fatty acids in broiler chickens. Poultry Science, 94, 345–352.
Zhu W H, Li D F, Wu H, Li J T, Chen Y Q, Guan H S, Zhang L Y. 2016. Effects of purified polymannuronate on the performance, immune status, antioxidant capacity, intestinal microbial populations and volatile fatty acid concentrations of weaned piglets. Animal Feed Science & Technology, 216, 161–168. |
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