Scientia Agricultura Sinica ›› 2010, Vol. 43 ›› Issue (10): 2162-2167 .doi: 10.3864/j.issn.0578-1752.2010.10.024

• VETERINARY SCIENCE • Previous Articles     Next Articles

Levels of Endothelin, Calcitonin Gene Related Peptide and Some Cardiopulmonary Parameters in Miniature Pigs Anesthetized with a Miniature Pig Combination Anesthetic

LU De-zhang, FAN Hong-gang, HU Kui, MA Hai-kun, ZHANG Jian-tao, LI Jing, WANG Hong-bin
   

  1. (东北农业大学动物医学学院)
  • Received:2008-12-04 Revised:2009-12-09 Online:2010-05-15 Published:2010-05-15
  • Contact: WANG Hong-bin

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Abstract:

【Objective】 The aim of this study was to investigate the effects of miniature pig combination anesthetic on the plasma ET, CGRP and some cardiopulmonary parameters in miniature pigs. 【Method】 Fourteen Chinese experimental miniature pigs were intramuscularly injected miniature pigs combination anesthetic at 0.15 mL•kg-1, and blood samples were collected in 0, 5, 10, 30, 45, 60, 80, 100 and 120 min, and simultaneously noninvasive blood pressure and HR were monitored. Plasma ET and CGRP were determined by radioimmunoassay. 【Results】 Blood pressure and HR were significantly changed from 5 to 10 min and at 80 min (P＜0.01 or P＜0.05). ET was changed similar to that of blood pressure, and the correlation between them was found (P＜0.05),and a negative correlation was observed between the CGRP and blood pressure (P＜0.05). 【Conclusion】 ET and CGRP participated in change of blood pressure which was caused by miniature pigs combination anesthetic, and ET and CGRP maybe the main reasons of change of blood pressure, which was caused by miniature pigs combination anesthetic.

Key words: miniature pigs, miniature pigs combination anesthetic, some cardiopulmonary parameters, ET, CGRP

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