Abstract: Abstract：24 goats were separated into immune control, immune and poisoning, poisoning groups randomly. Goats in immune control, immune and poisoning groups were vaccinated with SW-BSA. Goats in immune and poisoning, poisoning groups were fed with 10 g/kg BW/d power of O. kansuensis Bunge at each day. The changes of serum GOT, GPT, LDH, AKP, BUN and AMA were detected. The results showed that the increasing activity of LDH and GOT had been delayed 28 d, the increasing activity of AKP and BUN had been delayed 14 d, the decreasing activity of AMA had been delayed 21 d in immune and poisoning goats compared with poisoning goats. These results indicated that in 30 days, SW-BSA had prevented liver, kidney and heart of goats from injuring by SW effectively.