Abstract:

【Objective】 The basic formation rules and evaluation of the pharmaceutical microemulsions were studied in order to provide some experimental information to studying and application of pharmaceutical microemulsions. 【Method】 The titrimetric method for drawing pseudo-ternary phase diagrams was used to inspect the formation influence caused by different surfactants and CO-surfactant on the O/W microemulsions. 【Result】 In the same oil phase situation, the formation of microemulsions would be influenced by the structure and nature of surfactant and CO-surfactant, the quality ratio (Km) of surfactant and CO-surfactan as well as the temperature. 【Conclusion】 Appropriate oil phase and suitable matches of the surfactant and CO-surfactant can reduce the amount of surfactant in the microemulsion system to 7.5%. Moreover, in general, the region size of the microemulsions has a positive relationship with the total amount of surfactant and CO-surfactant, and has a negtive relationship with the oil used. In order to use drawing pseudo-ternary phase diagrams to determine the most excellent formation condition of pharmaceutical microemulsions, the stability of microemulsions needs to be unified.

Key words: pharmaceutical microemulsions')">pharmaceutical microemulsions, CO-surfactant, non-ionic surfactant, pseudo-ternary phase diagram