ApiAP2转录因子家族调控弓形虫生长发育的研究进展

doi:10.3864/j.issn.0578-1752.2024.13.015

中国农业科学 ›› 2024, Vol. 57 ›› Issue (13): 2687-2697.doi: 10.3864/j.issn.0578-1752.2024.13.015

ApiAP2转录因子家族调控弓形虫生长发育的研究进展

胡丹丹¹(), 罗润琪¹^,²(), 梁瑞英², 汪磊¹^,², 梁琳², 司红彬¹, 丁家波²(), 汤新明²()

¹ 广西大学动物科技学院，南宁 541000
² 中国农业科学院北京畜牧兽医研究所/农业农村部动物生物安全风险预警及防控重点实验室（北方）/农业农村部兽用生物制品与化学药品重点实验室，北京 100193

收稿日期:2023-12-23 接受日期:2024-03-14 出版日期:2024-07-09 发布日期:2024-07-09
通信作者:
丁家波，E-mail：dingjiabo@126.com。
汤新明，E-mail：tangxinming@caas.cn
联系方式: 胡丹丹，E-mail：hudandan@gxu.edu.cn。罗润琪，E-mail：luorunqi00@163.com。胡丹丹和罗润琪为同等贡献作者。
基金资助:
国家自然科学基金(32273035); 国家自然科学基金(31902295); 中国农业科学院青年创新专项(Y2023QC10)

Research Progress of ApiAP2 Transcription Factors in Regulating the Growth and Development of Toxoplasma gondii

HU DanDan¹(), LUO RunQi¹^,²(), LIANG RuiYing², WANG Lei¹^,², LIANG Lin², SI HongBin¹, DING JiaBo²(), TANG XinMing²()

¹ College of Animal Science and Technology, Guangxi University, Nanning 541000
² Institute of Animal Sciences, Chinese Academy of Agricultural Sciences/Key Laboratory of Animal Biosafety Risk Prevention and Control (North) of Ministry of Agriculture and Rural Affairs/Key Laboratory of Veterinary Biological Products and Chemical Drugs of Ministry of Agriculture and Rural Affairs, Beijing 100193

Received:2023-12-23 Accepted:2024-03-14 Published:2024-07-09 Online:2024-07-09

摘要/Abstract

摘要：

弓形虫病是世界范围内危害最为严重的人兽共患寄生虫病之一。WHO数据显示，全球人群弓形虫抗体阳性率在25%—50%。孕妇感染弓形虫引起的垂直传播严重危害胎儿及婴幼儿健康，弓形虫感染也是引起免疫缺陷病人死亡的主要因素。在畜牧生产中，弓形虫病引起孕畜流产、死胎，危害严重。弓形虫（Toxoplasma gondii）是一种专性细胞内原生动物寄生虫，属于顶复门原虫，生活史复杂，包括在中间宿主（人类和其他温血动物）的无性增殖和在终末宿主（猫科动物）的有性繁殖。为完成弓形虫在中间、终末宿主复杂的生命周期，其在不同发育阶段的转化及生长需要严格而精准的基因调控，因此揭示弓形虫生长发育的调控机制对治疗性药物和疫苗的研发具有重要意义。ApiAP2转录因子是一类具有AP2结构域和强大调节功能的蛋白家族，在疟原虫、弓形虫等寄生虫的生长发育中发挥核心调控作用，是阐明弓形虫不同生活史阶段发育与转化调控机制的突破口。弓形虫作为顶复门原虫研究的模式生物，有67个含AP2结构域的转录因子被注释，部分转录因子在弓形虫生命周期生长发育和转化过程中发挥核心调控功能，但尚有大部分AP2转录因子的生物学功能未知，尤其是针对有性繁殖阶段发育调控的研究较为匮乏。本文对已报道的弓形虫AP2转录因子的研究手段、生物学功能、调控的互作基因及网络进行系统梳理，旨在挖掘对弓形虫生长发育的重要节点起核心调控作用的基因或分子，在微观分子层面初步勾勒出弓形虫复杂生活史不同生长发育时期的调控机制，并对其在新型药物和疫苗研发中的作用及潜能进行展望。以期为动物弓形虫病的防控提供新的思路和切入点，阻断人弓形虫病的感染源，践行“人病兽防、关口前移”，实现“同一世界、同一健康”。

关键词: 刚地弓形虫, 生活史, 转录因子, 基因调控, 基因表达

Abstract:

Toxoplasmosis is one of the most serious zoonotic parasitic diseases in the world. WHO data show that the positive rate of Toxoplasma gondii antibody in the global population is 25%-50%. The vertical transmission caused by T. gondii infection in pregnant women seriously endangers the health of fetuses and infants, and T. gondii infection is also the main cause of death in immunocompromised patients. In livestock production, toxoplasmosis causes abortion and stillbirth in pregnant animals, which is seriously harmful. T. gondii is an obligate intracellular protozoan parasite that belongs to the apicomplexan protozoa, and its life cycle is complex, including asexual reproduction in intermediate hosts (humans and other warm-blooded animals) and sexual reproduction in terminal hosts (cats). In order to complete the complex life cycle of T. gondii in the intermediate and terminal hosts, its transformation and growth at different developmental stages require strict and accurate gene regulation. Therefore, revealing the regulatory mechanism of T. gondii growth and development is of great significance for the development of therapeutic drugs and vaccines. ApiAP2 transcription factor is a kind of protein family with AP2 domain and strong regulatory function, which plays a core regulatory role in the growth and development of parasites such as Plasmodium and T. gondii. It is a breakthrough to elucidate the regulation mechanism of development and transformation of T. gondii at different life cycle stages. As a model organism for the study of apicomplexan, 67 transcription factors containing AP2 domain have been annotated in T. gondii genome. Some of these transcription factors play crucial regulatory roles in the growth, development, and transformation processes of T. gondii throughout its life cycle. However, the biological functions of most AP2 transcription factors are unknown, especially the research on the development and regulation of sexual reproduction stage is relatively scarce. In this paper, the research methods, biological functions, regulatory interaction genes and networks of AP2 transcription factors of T. gondii have been systematically reviewed. The aim was to explore the genes or molecules that play a core regulatory role in the important nodes of T. gondii growth and development. The regulatory mechanism of different growth and development stages of T. gondii complex life cycle was preliminarily outlined at the micro molecular level, and its role and potential in the development of new drugs and vaccines were prospected. To provide new ideas and entry points for the prevention and control of animal toxoplasmosis and block the source of human toxoplasmosis infection, we should practice the concept of “disease prevention in animals and front-line defense” and strive to achieve “one world, one health” for everyone’s well-being.

Key words: Toxoplasma gondii, life cycle, transcription factors, gene regulation, gene expression

胡丹丹, 罗润琪, 梁瑞英, 汪磊, 梁琳, 司红彬, 丁家波, 汤新明. ApiAP2转录因子家族调控弓形虫生长发育的研究进展[J]. 中国农业科学, 2024, 57(13): 2687-2697.

HU DanDan, LUO RunQi, LIANG RuiYing, WANG Lei, LIANG Lin, SI HongBin, DING JiaBo, TANG XinMing. Research Progress of ApiAP2 Transcription Factors in Regulating the Growth and Development of Toxoplasma gondii[J]. Scientia Agricultura Sinica, 2024, 57(13): 2687-2697.

0
/ / 推荐

导出引用管理器 EndNote|Reference Manager|ProCite|BibTeX|RefWorks

链接本文: https://www.chinaagrisci.com/CN/10.3864/j.issn.0578-1752.2024.13.015

https://www.chinaagrisci.com/CN/Y2024/V57/I13/2687

图/表 2

图1

表1

ApiAP2转录因子在弓形虫性生长发育中的调控作用"

名称 Name	基因号 GeneID	研究时期 Research period	作用 Function	文献来源 Reference
AP2IX-4	TGME49_288950	速殖子到缓殖子 Tachyzoite to bradyzoite	调控缓殖子分化和包囊形成；调控毒力相关基因表达 Regulate bradyzoite differentiation and cyst formation; regulation of virulence-related gene expression	[60]
AP2XI-4	TGME49_115760	速殖子到缓殖子 Tachyzoite to bradyzoite	调控缓殖子分化和包囊形成 Regulate bradyzoite differentiation and cyst formation	[62]
AP2IV-4	TGME49_318470	速殖子到缓殖子 Tachyzoite to bradyzoite	调控缓殖子分化和包囊形成 Regulate bradyzoite differentiation and cyst formation	[61]
AP2X-4	TGME49_224050	速殖子 Tachyzoite	调控棒状体分泌蛋白相关基因的表达；调控入侵，毒力和速殖子分裂 Regulate the expression of rhoptry secretory protein-related genes; regulate invasion, virulence and tachyzoite division	[42]
AP2XII-5	TGME49_24773	缓殖子 Bradyzoite	调控毒力相关基因表达 Regulation of virulence-related gene expression	[42]
AP2IX-5	TGME49_289710	速殖子 Tachyzoite	激活顶质体的分裂程序以促进速殖子分裂 Activate the division program of apicoplast to promote tachyzoite division	[56]
AP2X-5	TGME49_237090	速殖子S期/M期 Tachyzoite S/M	调控毒力相关基因表达 Regulation of virulence-related gene expression	[55]
AP2XI-5	TGME49_216220	速殖子 Tachyzoite	与 GCTAGC 基序结合 Bind to the GCTAGC motif	[54]
AP2IX-9	TGME49_306620	速殖子到缓殖子 Tachyzoite to bradyzoite	抑制缓殖子分化和包囊形成；适应性实验室进化的关键驱动因素 Inhibition of bradyzoite differentiation and cyst formation; The key driving factors of adaptive laboratory evolution	[41]
AP2IV-3	TGME49_318610	速殖子到缓殖子 Tachyzoite to bradyzoite	调控缓殖子分化和包囊形成 Regulate bradyzoite differentiation and cyst formation	[41]
AP2XII-2	TGME49_217700	速殖子到缓殖子 Tachyzoite to bradyzoite	调控速殖子分裂，抑制包囊形成；与HDAC3 / MORC复合物互作，抑制有性生殖启动 Regulate tachyzoite division and inhibit cyst formation; it interacts with HDAC3 / MORC complex to inhibit the initiation of sexual reproduction	[52,63]
AP2XII-1	TGME49_218960	速殖子到裂殖子 Tachyzoite to merozoite	调控速殖子分裂，抑制裂殖子形成; 抑制缓殖子以及包囊的形成；与HDAC3 / MORC复合物互作，可能抑制有性生殖启动 Regulate bradyzoite differentiation and cyst formation; Inhibiting the formation of bradyzoites and cysts in type II strains; Interaction with HDAC3 / MORC complex may inhibit initiation of sexual reproduction	[65]
AP2XI-2	TGME49_310900	速殖子到裂殖子 Tachyzoite to merozoite	调控入侵和毒力与HDAC3 / MORC复合物互作调控缓殖子分化和包囊形成；抑制裂殖子分化 Regulate bradyzoite differentiation and cyst formation; Interaction with HDAC3 / MORC complex may inhibit initiation of sexual reproduction; Regulate bradyzoite differentiation and cyst formation; Inhibition of merozoite differentiation	[64,66]
AP2IX-1	TGME49_267460	速殖子到裂殖子 Tachyzoite to merozoite	调控有性生殖阶段表面抗原表达 Regulation of surface antigen expression in sexual reproduction stage	[58]

表1

参考文献 66

[1]	LEVINE N D. Progress in taxonomy of the api complexan Protozoa. The Journal of Protozoology, 1988, 35(4): 518-520.
[2]	DAHER D, SHAGHLIL A, SOBH E, HAMIE M, HASSAN M E, MOUMNEH M B, ITANI S, EL HAJJ R, TAWK L, EL SABBAN M, EL HAJJ H. Comprehensive overview of Toxoplasma gondii-induced and associated diseases. Pathogens, 2021, 10(11): 19.
[3]	TANDEL J, WALZER K A, BYERLY J H, PINKSTON B, BEITING D P, STRIEPEN B. Genetic ablation of a female-specific apetala 2 transcription factor blocks oocyst shedding in Cryptosporidium parvum. mBio, 2023, 14(2): e0326122.
[4]	SHWAB E K, SARAF P, ZHU X Q, ZHOU D H, MCFERRIN B M, AJZENBERG D, SCHARES G, HAMMOND-ARYEE K, VAN HELDEN P, HIGGINS S A, GERHOLD R W, ROSENTHAL B M, ZHAO X P, DUBEY J P, SU C L. Human impact on the diversity and virulence of the ubiquitous zoonotic parasite Toxoplasma gondii. Proceedings of the National Academy of Sciences of the United States of America, 2018, 115(29): e6956.
[5]	ZHOU D H, ZHAO F R, LU P, XIA H Y, XU M J, YUAN L G, YAN C, HUANG S Y, LI S J, ZHU X Q. Seroprevalence of Toxoplasma gondii infection in dairy cattle in Southern China. Parasites & Vectors, 2012, 5(1): 48.
[6]	PAN M, LYU C C, ZHAO J L, SHEN B. Sixty years (1957-2017) of research on toxoplasmosis in China-An overview. Frontiers in Microbiology, 2017, 8: 1825.
[7]	HOSEIN S, LIMON G, DADIOS N, GUITIAN J, BLAKE D P. Toxoplasma gondii detection in cattle: A slaughterhouse survey. Veterinary Parasitology, 2016, 228: 126-129.
[8]	HUANG M, HUANG H J, CAO X R, YIN Y W, SHI K C, WANG D Y, HU D D, SONG X J. Seroprevalence of Toxoplasma gondii in water buffaloes and cats in Guangxi, China. Parasitology Research, 2023, 123(1): 18.
[9]	SHAPIRO K, BAHIA-OLIVEIRA L, DIXON B, DUMÈTRE A, DE WIT L A, VANWORMER E, VILLENA I. Environmental transmission of Toxoplasma gondii: Oocysts in water, soil and food. Food and Waterborne Parasitology, 2019, 15: e00049.
[10]	FRENKEL J K, RUIZ A, CHINCHILLA M. Soil survival of toxoplasma oocysts in Kansas and Costa Rica. The American Journal of Tropical Medicine and Hygiene, 1975, 24(3): 439-443.
[11]	陈秀春, 周世昌, 刘锦华. 弓形虫感染与优生. 泰山医学院学报, 2004, 25(5): 480-482.
	CHEN X C, ZHOU S C, LIU J H. Toxoplasma gondii infection and eugenics. Journal of Taishan Medical College, 2004, 25(5): 480-482. (in Chinese)
[12]	李慧珠. 弓形虫与弓形虫病. 生物学通报, 2002, 37(5): 9-12.
	LI H Z. Toxoplasma and toxoplasmosis. Bulletin of Biology, 2002, 37(5): 9-12. (in Chinese)
[13]	钱铭智, 马以武, 卢慎. 孕妇弓形虫感染与胎儿畸形关系的初步观察. 南京医学院学报, 1990(2): 124-125.
	QIAN M Z, MA Y W, LU S. Preliminary observation on the relationship between Toxoplasma gondii infection in pregnant women and fetal malformation. Journal of Nanjing Medical University, 1990(2): 124-125. (in Chinese)
[14]	胡建辉, 王英. 人弓形虫病临床研究的进展. 医学综述, 1996, 2(6): 306-307.
	HU J H, WANG Y. Progress of clinical research on human toxoplasmosis. Medical Recapitulate, 1996, 2(6): 306-307. (in Chinese)
[15]	卢慎. 弓形虫病宫内感染100例胎婴儿的病理学观察. 中国寄生虫病防治杂志, 1994(3): 209-212.
	LU S. Pathological observation of 100 cases of toxoplasmosis intrauterine infection in infants. Journal of Pathogen Biology, 1994(3): 209-212. (in Chinese)
[16]	DUBEY J P, LAGO E G, GENNARI S M, SU C, JONES J L. Toxoplasmosis in humans and animals in Brazil: High prevalence, high burden of disease, and epidemiology. Parasitology, 2012, 139(11): 1375-1424. doi: 10.1017/S0031182012000765 pmid: 22776427
[17]	ZIELIŃSKI A. Toxoplasmosis in patients with AIDS. Przeglad Epidemiologiczny, 1995, 49(4): 343-352.
[18]	MONTOYA J G, LIESENFELD O. Toxoplasmosis. The Lancet, 2004, 363(9425): 1965-1976.
[19]	FOND G, CAPDEVIELLE D, MACGREGOR A, ATTAL J, LARUE A, BRITTNER M, DUCASSE D, BOULENGER J P. Toxoplasma gondii: a potential role in the genesis of psychiatric disorders. Encephale, 2013, 39(1): 38-43.
[20]	张钦. 我国部分地区猪弓形虫血清学调查[D]. 合肥: 安徽农业大学, 2016.
	ZHANG Q. The serological investigation of pigs’ Toxoplasma gondii from some regions of China[D]. Hefei: Anhui Agricultural University, 2016. (in Chinese)
[21]	王祎, 杨磊. 猪弓形虫病的研究进展. 畜牧兽医科技信息, 2022(11): 10-12.
	WANG Y, YANG L. Research progress of porcine toxoplasmosis. Chinese Journal of Animal Husbandry and Veterinary Medicine, 2022(11): 10-12. (in Chinese)
[22]	SULLIVAN W J Jr, HAKIMI M A. Histone mediated gene activation in Toxoplasma gondii. Molecular and Biochemical Parasitology, 2006, 148(2): 109-116.
[23]	KIM K. The epigenome, cell cycle, and development in Toxoplasma. Annual Review of Microbiology, 2018, 72: 479-499.
[24]	JENINGA M, QUINN J, PETTER M. ApiAP2 transcription factors in api complexan parasites. Pathogens, 2019, 8(2): 47.
[25]	PIESZKO M, WEIR W, GOODHEAD I, KINNAIRD J, SHIELS B. ApiAP2 factors as candidate regulators of stochastic commitment to merozoite production in Theileria annulata. PLoS Neglected Tropical Diseases, 2015, 9(8): e0003933.
[26]	SUBUDHI A, GREEN J L, SATYAM R, SALUNKE R P, LENZ T, SHUAIB M, ISAIOGLOU I, ABEL S, GUPTA M, ESAU L, MOURIER T, et al. DNA-binding protein PfAP2-P regulates parasite pathogenesis during malaria parasite blood stages. Nature Microbiology. 2023, 8(11):2154-2169. doi: 10.1038/s41564-023-01497-6 pmid: 37884813
[27]	CAI W M, FENG Q Q, WANG L Y, SU S J, HOU Z F, LIU D D, KANG X L, XU J J, PAN Z M, TAO J P. Localization in vivo and in vitro confirms EnApiAP2 protein encoded by ENH_00027130 as a nuclear protein in Eimeria necatrix. Frontiers in Cellular and Infection Microbiology, 2023, 13: 1305727.
[28]	CHEN L L, TANG X M, SUN P, HU D D, ZHANG Y Y, WANG C Y, CHEN J M, LIU J, GAO Y, HAO Z K, ZHANG N, CHEN W X, XIE F J, SUO X, LIU X Y. Comparative transcriptome profiling of Eimeria tenella in various developmental stages and functional analysis of an ApiAP2 transcription factor exclusively expressed during sporogony. Parasites & Vectors, 2023, 16(1): 241.
[29]	SUVOROVA E S, RADKE J B, TING L M, VINAYAK S, ALVAREZ C A, KRATZER S, KIM K, STRIEPEN B, WHITE M W. A nucleolar AAA-NTPase is required for parasite division. Molecular Microbiology, 2013, 90(2): 338-355. doi: 10.1111/mmi.12367 pmid: 23964771
[30]	RIECHMANN J L, MEYEROWITZ E M. The AP2/EREBP family of plant transcription factors. Biological Chemistry, 1998, 379(6): 633-646. doi: 10.1515/bchm.1998.379.6.633 pmid: 9687012
[31]	BALAJI S, BABU M M, IYER L M, ARAVIND L. Discovery of the principal specific transcription factors of Api complexa and their implication for the evolution of the AP2-integrase DNA binding domains. Nucleic Acids Research, 2005, 33(13): 3994-4006.
[32]	LINDNER S E, DE SILVA E K, KECK J L, LLINÁS M. Structural determinants of DNA binding by a P. falciparum ApiAP2 transcriptional regulator. Journal of Molecular Biology, 2010, 395(3): 558-567.
[33]	ALLEN M D, YAMASAKI K, OHME-TAKAGI M, TATENO M, SUZUKI M. A novel mode of DNA recognition by a beta-sheet revealed by the solution structure of the GCC-box binding domain in complex with DNA. The EMBO Journal, 1998, 17(18): 5484-5496.
[34]	CAMPBELL T L, DE SILVA E K, OLSZEWSKI K L, ELEMENTO O, LLINÁS M. Identification and genome-wide prediction of DNA binding specificities for the ApiAP2 family of regulators from the malaria parasite. PLoS Pathogens, 2010, 6(10): e1001165.
[35]	RUIZ J L, TENA J J, BANCELLS C, CORTÉS A, GÓMEZ- SKARMETA J L, GÓMEZ-DÍAZ E. Characterization of the accessible genome in the human malaria parasite Plasmodium falciparum. Nucleic Acids Research, 2018, 46(18): 9414-9431.
[36]	ARAVIND L, LANDSMAN D. AT-hook motifs identified in a wide variety of DNA-binding proteins. Nucleic Acids Research, 1998, 26(19): 4413-4421. doi: 10.1093/nar/26.19.4413 pmid: 9742243
[37]	HARRIS M T, JEFFERS V, MARTYNOWICZ J, TRUE J D, MOSLEY A L, SULLIVAN W J Jr. A novel GCN5b lysine acetyltransferase complex associates with distinct transcription factors in the protozoan parasite Toxoplasma gondii. Molecular and Biochemical Parasitology, 2019, 232: 111203.
[38]	FARHAT D C, SWALE C, DARD C, CANNELLA D, ORTET P, BARAKAT M, SINDIKUBWABO F, BELMUDES L, DE BOCK P J, COUTÉ Y, BOUGDOUR A, HAKIMI M A. A MORC-driven transcriptional switch controls Toxoplasma developmental trajectories and sexual commitment. Nature Microbiology, 2020, 5: 570-583.
[39]	YAKUBU R R, SILMON DE MONERRI N C, NIEVES E, KIM K, WEISS L M. Comparative monomethylarginine proteomics suggests that protein arginine methyltransferase 1 (PRMT1) is a significant contributor to arginine monomethylation in Toxoplasma gondii. Molecular & Cellular Proteomics, 2017, 16(4): 567-580.
[40]	PRIMO V A Jr, REZVANI Y, FARRELL A, MURPHY C Q, LOU J J, VAJDI A, MARTH G T, ZARRINGHALAM K, GUBBELS M J. The extracellular milieu of Toxoplasma’s lytic cycle drives lab adaptation, primarily by transcriptional reprogramming. mSystems, 2021, 6(6): e0119621.
[41]	HONG D P, RADKE J B, WHITE M W. Opposing transcriptional mechanisms regulate Toxoplasma development. mSphere, 2017, 2(1): e00347.
[42]	张晶雯. AP2X-4和AP2XⅡ-5对弓形虫生长发育的调节作用[D]. 武汉: 华中农业大学, 2020.
	ZHANG J W. Regulation of Toxoplasma gondii growth and development by AP2X-4 and AP2XⅡ-5[D]. Wuhan: Huazhong Agricultural University, 2020. (in Chinese)
[43]	WEILHAMMER D R, IAVARONE A T, VILLEGAS E N, BROOKS G A, SINAI A P, SHA W C. Host metabolism regulates growth and differentiation of Toxoplasma gondii. International Journal for Parasitology, 2012, 42(10): 947-959.
[44]	YIN D Q, JIANG N, CHENG C, SANG X Y, FENG Y, CHEN R, CHEN Q J. Protein lactylation and metabolic regulation of the zoonotic parasite Toxoplasma gondii. Genomics, Proteomics & Bioinformatics, 2023, 21(6): 1163-1181.
[45]	HEREDERO-BERMEJO I, VARBERG J M, CHARVAT R, JACOBS K, GARBUZ T, SULLIVAN W J Jr, ARRIZABALAGA G. TgDrpC, an atypical dynamin-related protein in Toxoplasma gondii, is associated with vesicular transport factors and parasite division. Molecular Microbiology, 2019, 111(1): 46-64.
[46]	WANG J C, DIXON S E, TING L M, LIU T K, JEFFERS V, CROKEN M M, CALLOWAY M, CANNELLA D, ALI HAKIMI M, KIM K, SULLIVAN W J. Lysine acetyltransferase GCN5b interacts with AP2 factors and is required for Toxoplasma gondii proliferation. PLoS Pathogens, 2014, 10(1): e1003830.
[47]	CROKEN M M, MA Y F, MARKILLIE L M, TAYLOR R C, ORR G, WEISS L M, KIM K. Distinct strains of Toxoplasma gondii feature divergent transcriptomes regardless of developmental stage. PLoS ONE, 2014, 9(11): e111297.
[48]	RADKE J B, LUCAS O, DE SILVA E K, MA Y F, SULLIVAN W J Jr, WEISS L M, LLINAS M, WHITE M W. ApiAP2 transcription factor restricts development of the Toxoplasma tissue cyst. Proceedings of the National Academy of Sciences of the United States of America, 2013, 110(17): 6871-6876.
[49]	GUBBELS M J, COPPENS I, ZARRINGHALAM K, DURAISINGH M T, ENGELBERG K. The modular circuitry of api complexan cell division plasticity. Frontiers in Cellular and Infection Microbiology, 2021, 11: 670049.
[50]	ZARRINGHALAM K, YE S D, LOU J J, REZVANI Y, GUBBELS M J. Cell cycle-regulated ApiAP2s and parasite development: The Toxoplasma paradigm. Current Opinion in Microbiology, 2023, 76: 102383.
[51]	BEHNKE M S, WOOTTON J C, LEHMANN M M, RADKE J B, LUCAS O, NAWAS J, SIBLEY L D, WHITE M W. Coordinated progression through two subtranscriptomes underlies the tachyzoite cycle of Toxoplasma gondii. PLoS ONE, 2010, 5(8): e12354.
[52]	SRIVASTAVA S, WHITE M W, SULLIVAN W J Jr. Toxoplasma gondii AP2XII-2 contributes to proper progression through S-phase of the cell cycle. mSphere, 2020, 5(5): e00542.
[53]	LAI B S, WITOLA W H, BISSATI K E, ZHOU Y, MUI E, FOMOVSKA A, MCLEOD R. Molecular target validation, antimicrobial delivery, and potential treatment of Toxoplasma gondii infections. Proceedings of the National Academy of Sciences of the United States of America, 2012, 109(35): 14182-14187.
[54]	WALKER R, GISSOT M, HUOT L, ALAYI T D, HOT D, MAROT G, SCHAEFFER-REISS C, VAN DORSSELAER A, KIM K, TOMAVO S. Toxoplasma transcription factor TgAP2XI-5 regulates the expression of genes involved in parasite virulence and host invasion. The Journal of Biological Chemistry, 2013, 288(43): 31127-31138.
[55]	LESAGE K M, HUOT L, MOUVEAUX T, COURJOL F, SALIOU J M, GISSOT M. Cooperative binding of ApiAP2 transcription factors is crucial for the expression of virulence genes in Toxoplasma gondii. Nucleic Acids Research, 2018, 46(12): 6057-6068.
[56]	KHELIFA A S, GUILLEN SANCHEZ C, LESAGE K M, HUOT L, MOUVEAUX T, PERICARD P, BAROIS N, TOUZET H, MAROT G, ROGER E, GISSOT M. TgAP2IX-5 is a key transcriptional regulator of the asexual cell cycle division in Toxoplasma gondii. Nature Communications, 2021, 12: 116.
[57]	SZATANEK T, ANDERSON-WHITE B R, FAUGNO-FUSCI D M, WHITE M, SAEIJ J P, GUBBELS M J. Cactin is essential for G1 progression in Toxoplasma gondii. Molecular Microbiology, 2012, 84(3): 566-577.
[58]	XUE Y, THEISEN T C, RASTOGI S, FERREL A, QUAKE S R, BOOTHROYD J C. A single-parasite transcriptional atlas of Toxoplasma gondii reveals novel control of antigen expression. eLife, 2020, 9: e54129.
[59]	WALDMAN B S, SCHWARZ D, WADSWORTH M H 2nd, SAEIJ J P, SHALEK A K, LOURIDO S. Identification of a master regulator of differentiation in Toxoplasma. Cell, 2020, 180(2): 359-372.
[60]	HUANG S, HOLMES M J, RADKE J B, HONG D P, LIU T K, WHITE M W, SULLIVAN W J Jr. Toxoplasma gondii AP2IX-4 regulates gene expression during bradyzoite development. mSphere, 2017, 2(2): e00054.
[61]	RADKE J B, WORTH D, HONG D, HUANG S, SULLIVAN W J Jr, WILSON E H, WHITE M W. Transcriptional repression by ApiAP2 factors is central to chronic toxoplasmosis. PLoS Pathogens, 2018, 14(5): e1007035.
[62]	WALKER R, GISSOT M, CROKEN M M, HUOT L, HOT D, KIM K, TOMAVO S. The Toxoplasma nuclear factor TgAP2XI-4 controls bradyzoite gene expression and cyst formation. Molecular Microbiology, 2013, 87(3): 641-655.
[63]	SULLIVAN W J Jr. Toxoplasma gondii AP2XII-2 contributes to transcriptional repression for sexual commitment. mSphere, 2023, 8(2): e0060622.
[64]	ANTUNES A V, SHAHINAS M, SWALE C, FARHAT D C, RAMAKRISHNAN C, BRULEY C, CANNELLA D, ROBERT M G, CORRAO C, COUTÉ Y, HEHL A B, BOUGDOUR A, COPPENS I, HAKIMI M A. In vitro production of cat-restricted Toxoplasma pre-sexual stages. Nature, 2024, 625: 366-376.
[65]	FAN F Q, XUE L L, YIN X Y, GUPTA N, SHEN B. AP2XII-1 is a negative regulator of merogony and presexual commitment in Toxoplasma gondii. mBio, 2023, 14(5): e0178523.
[66]	WANG J L, LI T T, ZHANG N Z, WANG M, SUN L X, ZHANG Z W, FU B Q, M ELSHEIKHA H, ZHU X Q. The transcription factor AP2XI-2 is a key negative regulator of Toxoplasma gondii merogony. Nature Communications. 2024, 15(1):793.

ApiAP2转录因子家族调控弓形虫生长发育的研究进展

Research Progress of ApiAP2 Transcription Factors in Regulating the Growth and Development of Toxoplasma gondii

RichHTML

PDF

赞

可视化

摘要/Abstract

引用本文

使用本文

图/表 2

参考文献 66

相关文章 15

Metrics

本文评价

推荐阅读 0

[1]	姜兴林, 于连伟, 付涵, 艾妞, 崔荧钧, 李好海, 夏子豪, 袁虹霞, 李洪连, 杨雪, 施艳. 转录因子NbMYB1R1通过促进活性氧积累抑制病毒侵染[J]. 中国农业科学, 2024, 57(8): 1490-1505.
[2]	陈兵先, 张琪, 戴彰言, 周旭, 刘军. 水杨酸引发提高低温下水稻种子萌发活力的生理与分子效应[J]. 中国农业科学, 2024, 57(7): 1220-1236.
[3]	王程泽, 张燕, 付伟, 贾京哲, 董金皋, 申珅, 郝志敏. 玉米ACO基因家族生物信息学及表达模式分析[J]. 中国农业科学, 2024, 57(7): 1308-1318.
[4]	杨浩蓉, 贾凡, 胡徐, 穆蓉, 刘维娜, 刘昌云, 王善之, 孙现超, 马冠华, 陈国康. 油菜BnJAZ7通过调控抗氧化途径促进核盘菌侵染[J]. 中国农业科学, 2024, 57(19): 3799-3809.
[5]	魏晓东, 宋雪梅, 王宁, 赵庆勇, 朱镇, 陈涛, 赵凌, 王才林, 张亚东. 南粳系列超级稻品种灌浆期光合产物的分配特性[J]. 中国农业科学, 2024, 57(12): 2309-2321.
[6]	李慧, 张雨峰, 李晓刚, 王中华, 蔺经, 常有宏. 全基因组DNA甲基化和转录组联合分析鉴定杜梨耐盐相关转录因子[J]. 中国农业科学, 2023, 56(7): 1377-1390.
[7]	李懿璞, 童丽秀, 蔺雅楠, 苏治军, 包海柱, 王富贵, 刘剑, 屈佳伟, 胡树平, 孙继颖, 王志刚, 于晓芳, 徐明良, 高聚林. 玉米ZmCCT10耐低氮功能研究[J]. 中国农业科学, 2023, 56(6): 1035-1044.
[8]	渠清, 刘宁, 邹金鹏, 张雅璇, 贾慧, 孙蔓莉, 曹志艳, 董金皋. 拟轮枝镰孢与玉米籽粒互作的差异基因筛选及代谢通路分析[J]. 中国农业科学, 2023, 56(6): 1086-1101.
[9]	邹婷, 刘丽莉, 向建华, 周定港, 吴金锋, 李莓, 李宝, 张大为, 严明理. 芸薹属植物MYBL2基因的克隆及其在A、B、C基因组中的PCR鉴别[J]. 中国农业科学, 2023, 56(3): 416-429.
[10]	罗正英, 胡鑫, 刘新龙, 吴才文, 吴转娣, 刘家勇, 曾千春. 外源海藻糖提高甘蔗幼苗抗旱能力并促进植株生长[J]. 中国农业科学, 2023, 56(21): 4208-4218.
[11]	李美璇, 张向昆, 王莉, 乔月莲, 师校欣, 杜国强. 沙地葡萄茎痘相关病毒在‘阳光玫瑰’葡萄树不同物候期和不同部位的变化规律[J]. 中国农业科学, 2023, 56(21): 4234-4244.
[12]	颜培涵, 罗健铭, 郝晨星, 孙紫青, 叶蓉春, 李益, 刘恋, 盛玲, 马先锋, 邓子牛. 枸橼C-05 CmPR4A上游转录因子CmWRKY75的筛选及其抗溃疡病功能分析[J]. 中国农业科学, 2023, 56(21): 4304-4317.
[13]	韩晓文, 韩硕, 胡义锋, 王梦如, 陈中义, 朱永兴, 尹军良. 喜旱莲子草AP2/ERF基因家族的鉴定及其在除草剂胁迫下的表达模式[J]. 中国农业科学, 2023, 56(20): 4021-4034.
[14]	杨丽, 曹洪波, 张学英, 翟含含, 李辛淼, 彭佳伟, 田义, 陈海江. 桃生长势相关基因PpSAUR73功能鉴定[J]. 中国农业科学, 2023, 56(20): 4072-4086.
[15]	丁国华, 肖光辉, 竺丽萍. 棉花NLP（NIN-Like Protein）基因家族的全基因组鉴定及表达分析[J]. 中国农业科学, 2023, 56(19): 3723-3746.