关键词: 转基因大米')">转基因大米, 赖氨酸, 稻米, 安全评价

Abstract: 【Objective】Rats were fed by transgenic rice expressing lysine-rich protein fusion gene to study if the transgenic rice possesses potential toxic or adverse effects.【Method】According to the composition of the transgenic GL gene rice and its parental rice, a nutritionally balanced purified diet with 70% transgenic GL gene rice or 70% parental rice was prepared. And the nutrition of the diet was the same as the control diet. Sixty weanling Sprague-Dawley rats were divided into three groups according to their sex and weight respectively: transgenic rice group, nontransgenic rice group, and control group. They were fed with corresponding diet for 90 days. Indicators including body weight, feed volume, feed utilization rate, blood routine test, blood biochemistry test, urinary routine test, relative organ weights and organ histopathological examinations were observed. 【Result】No significant differences were found between transgenic rice group and non-transgenic rice group (P＞0.05) and no histopathological damage was detected. Female feed volume and CHOL of male serum of terminal experiment in transgenic rice group were lower than those of control group (P＜0.05). Female feed utilization rate, MCV of male whole blood of terminal experiment, AST of male serum of midterm experiment, AST/ALT and P of male serum of terminal experiment were higher than those of control group (P＜0.05), but biological differences were not observed, and the values of all the blood routine parameters and serum parameters were still within the normal ranges of values for rats of this age and sex.【Conclusion】Transgenic rice has no adverse effects on rats, and the transgenic rice is as safe and wholesome as its parental rice.

Key words: transgenic rice')">transgenic rice, lysine, rice, safety evaluation