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Journal of Integrative Agriculture
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Development of biodegradable triple-stimuli-responsive mesoporous organosilica nanocarriers for targeted pesticide delivery and enhanced plant immunity in rice disease management
Yuchen Song1, Sijin Wang1, Yuehong Du1, Zhenyu Li1, Yumeng Yuan1, Yihan Chen1, Wanwan Wang2, Hongqiang Dong3, Zhongyang Huo1, You Liang1, 4#
1 Co-Innovation Center for Modern Production Technology of Grain Crops/Jiangsu Key Laboratory of Crop Genetics and Physiology/Research Institute of Rice Industrial Engineering Technology, Yangzhou University, Yangzhou 225009, China
2 Jiangsu Key Laboratory of Chiral Pharmaceuticals Biosynthesis, Taizhou University, Taizhou 225300, China
3 College of Agriculture, Tarim University, Alaer 843300, China
4 State Key Laboratory of Green Pesticides/Key Laboratory of Green Pesticide and Agricultural Bioengineering/Ministry of Education, Center for Research and Development of Fine Chemicals, Guizhou University, Guiyang 550025, China

 Highlights 

l PYR@MON-COS exhibited pH-, redox-, and enzyme-responsive release properties and improved the photostability of PYR.

l PYR@MON-COS triggered immune responses in rice, promoting callose deposition in leaves.

l The nanocarrier system improved pesticide adhesion and penetration in plant tissues.

l PYR@MON-COS increased the antifungal efficacy and prolonged the effective duration of PYR.

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摘要  

开发新型刺激响应型农药递送系统是提高农药利用率并降低环境风险的有效策略本研究通过将壳寡糖(COS)共价接枝含有可降解二硫键的有机介孔二氧化硅纳米颗粒(MONs),并负载吡唑醚菌酯PYR,成功构建了一种pH/谷胱甘肽/几丁质酶三重刺激响应的农药递送系统。该系统的载药量为 13.6%,其 COS 修饰层可有效保护活性成分免受光降解,并防止 PYR 过早释放。在稻瘟病菌(Magnaporthe oryzae)侵染过程中,感染部位的pH降低、谷胱甘肽浓度升高以及几丁质酶酶活性增强可协同触发二硫键断裂与 COS 酶解,实现 PYR 的靶向快速释放。此外,PYR@MONs-COS显著提升了PYR在水稻叶片中的渗透能力和农药液滴的附着性能并诱导水稻叶片细胞中胼胝质的沉积,提高了水稻自身的免疫力离体和活体抗菌活性结果表明,与PYR微胶囊相比,PYR@MONs-COS对水稻稻瘟病表现出更的防效和更长的持效期。安全性评估表明PYR@MONs-COS对水稻无明显毒性,且对斑马鱼的急性毒性相比原药降低了7.3倍。因此,这种三重刺激响应的农药递送系统在水稻病害防治中具有广阔的应用前景,并为可持续农业的发展提供了一条有前景的途径。



Abstract  

The development of novel stimuli-responsive pesticide delivery systems is a highly effective strategy for improving pesticide utilization efficiency while minimizing environmental risks. A pH-, glutathione-, and chitinase-responsive pesticide delivery system was designed by conjugating chitosan oligosaccharide (COS) with biodegradable disulfide bond-bridged mesoporous silica nanoparticles (MONs) loaded with pyraclostrobin (PYR@MONs-COS). The loading capacity of PYR in the nanoparticles was approximately 13.6%. The covalent attachment of COS to the modified MONs could effectively protect the active ingredient from photodegradation and prevent premature release of PYR. During the infection process, physiological and biochemical changes at the infection site, including reduced pH values, increased glutathione levels, and enhanced chitinase activity, facilitated the rapid degradation of disulfide bonds and COS in PYR@MONs-COS, resulting in the rapid release of PYR. Furthermore, PYR@MONs-COS significantly enhanced the foliar penetration of PYR, improved the adhesion of pesticide droplets, and stimulated callose deposition in rice leaves, thus strengthening the immunity of rice plants. In antifungal activity assays, PYR@MONs-COS exhibited superior efficacy and longer effective duration against Magnaporthe oryzae compared to PYR microcapsules in both in vitro and in vivo experiments. The phytotoxicity assessment indicated that PYR@MONs-COS was safe for rice plants. More importantly, PYR@MONs-COS demonstrated a 7.3-fold reduction in acute toxicity to zebrafish compared to PYR technical. Therefore, the triple-stimuli pesticide delivery system has great potential for rice disease management and provides a promising pathway for the development of sustainable agriculture.

Keywords:  mesoporous organosilica nanoparticles       stimuli-responsive pesticide delivery       chitosan oligosaccharide       rice disease management       plant immunity  
Online: 10 June 2025  
Fund: 

This work was supported by the Carbon Peak Carbon Neutral Science and Technology Innovation Special Fund of Jiangsu Province, China (BE2022424), the National Natural Science Foundation of China (32102293), the Earmarked Fund for China Agricultural Research System (CARS-01-26), the Jiangsu Agricultural Science and Technology Innovation Fund, China (CX(22)1001), the Bingtuan Science and Technology Program, China (2024DA004), the Taizhou Science and Technology Support Program (Agriculture) Project, China (TN202222), the Postgraduate Research & Practice Innovation Program of Jiangsu Province, China (KYCX23_3578), the College Students’ Innovative Entrepreneurial Training Plan Program, China (202411117194Y and XCX20240676), and the Priority Academic Program Development of Jiangsu Higher Education Institutions, China (PAPD).

About author:  Yuchen Song, E-mail: m18852712482@163.com; #Correspondence You Liang, Tel: + 86-514-87972363, E-mail: liangyou@yzu.edu.cn

Cite this article: 

Yuchen Song, Sijin Wang, Yuehong Du, Zhenyu Li, Yumeng Yuan, Yihan Chen, Wanwan Wang, Hongqiang Dong, Zhongyang Huo, You Liang. 2025. Development of biodegradable triple-stimuli-responsive mesoporous organosilica nanocarriers for targeted pesticide delivery and enhanced plant immunity in rice disease management. Journal of Integrative Agriculture, Doi:10.1016/j.jia.2025.06.019

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