As a short-day (SD) and thermophilic plant, soybean (Glycine max (L.) Merr.) is sensitive to photo-thermal conditions.  This characteristic severely limits the cultivation range of a given soybean cultivar and affects the performances of agronomic traits such as yield, plant architectures, and seed quality.  Therefore, understanding the mechanism of photo-thermal sensitivity will provide a theoretical basis for soybean improvement.  In this review, we introduce the advances in physiological, genetic, and molecular researches in photoperiodism of soybean, and progress in the improvement of the photo-thermal adaptability.  We also summarize the photo-thermal conditions and characteristics of widely-planted soybean cultivars of major production regions in China.  Furthermore, we proposed a novel concept of ‘ecotyping’ and the strategies for widely-adapted soybean cultivar breeding.  This review provides an important guide for improving the adaptability of soybean.