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| Regulation of influenza virus infection by microRNAs |
ZOU Zhong1, 2, 3*, GONG Wen-xiao1, 2, 3*, HUANG Kun1, 2, SUN Xiao-mei1, 2, 3, JIN Mei-lin1, 2, 3 |
1 State Key Laboratory of Agricultural Microbiology, Huazhong Agricultural University, Wuhan 430070, P.R.China
2 College of Veterinary Medicine, Huazhong Agricultural University, Wuhan 430070, P.R.China
3 Key Laboratory of Development of Veterinary Diagnostic Products, Ministry of Agriculture and Rural Affairs, Wuhan 430070, P.R.China |
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Abstract MicroRNAs (miRNAs) are small noncoding RNAs of 18–25 nucleotides (nt) in length that represent key regulators of many normal cellular functions through the inhibition of mRNA translation and mRNA degradation. To date, over 2 500 mature miRNAs have been identified in plants, animals and several types of viruses. Influenza A virus (IAV), which is a negative-sense, single-stranded RNA virus, does not encode viral miRNA. However, IAV infection can alter the expression of host miRNAs, either in cell culture or in host. In turn, host miRNAs regulate IAV life cycle through directly binding to IAV genome or indirectly targeting host factors associated with viral replication. In this review, we briefly summarized the role and significance of miRNA in relation to IAV pathogenesis. Understanding the role of cellular miRNAs during viral infection may be beneficial to the identification of novel therapeutic strategies to block IAV replication.
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Received: 21 August 2018
Online: 07 November 2018
Accepted:
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| Fund: This research was supported by the National Key Research and Development Program of China (2016YFD0501600). |
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Corresponding Authors:
Correspondence JIN Mei-lin, E-mail: jml8328@126.com
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| About author: * These authors contributed equally to this study. |
Cite this article:
ZOU Zhong, GONG Wen-xiao, HUANG Kun, SUN Xiao-mei, JIN Mei-lin.
2019.
Regulation of influenza virus infection by microRNAs. Journal of Integrative Agriculture, 18(7): 1421-1427.
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