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Journal of Integrative Agriculture  2026, Vol. 25 Issue (5): 1760-1787    DOI: 10.1016/j.jia.2025.06.005
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Recent research progress and outlook on the bioactivities and mechanism of piperazine pesticides

Yanju Wang, Baoan Song#

State Key Laboratory of Green Pesticides, Guizhou University, Guiyang 550025, China

 Highlights 

• Research progress on the pesticide biological activities of piperazine derivatives is summarized.

• The mechanism action of the biological activities of piperazine derivatives as pesticides is discussed and analyzed.

• The future directions of pesticide structural derivation and the mechanism action of piperazine derivatives are prospected.

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摘要  

哌嗪是一种含氮杂环化合物,在化合物的结构衍生物中通常用作中间连接基团。含哌嗪的杂环类药物在医学上有许多商业用途,也用于农药。例如,哌嗪环是系统性杀菌剂嗪氨灵的关键结构元素。哌嗪因其对哺乳动物急性毒性低而备受关注,成为近年来杂环农药研究的热点之一。哌嗪类衍生物的农药活性及其作用机理已被广泛研究。本文对1971-2025年间哌嗪类衍生物的农药生物活性和作用机理进行了综述。讨论了哌嗪类衍生物的农业抗真菌、杀虫、抗植物病毒、除草、杀螨和抗菌活性,并综述了相关衍生物的分子作用机理。此外,我们还提出了哌嗪结构的未来衍生方向,并对其抗植物病毒和抗菌作用机制的发展方向进行了展望。



Abstract  

Piperazine is a nitrogen-containing heterocyclic compound that is commonly used as an intermediate linking group in the structural derivation of compounds.  Heterocyclic drugs containing piperazine have many commercial uses in medicine and are also used in pesticides.  For example, the piperazine ring is a key structural element of the systemic fungicide Triforine.  Piperazine is an attractive option because of its low acute toxicity to mammals, and it has become one of the hotspots of heterocyclic pesticide research in recent years.  The pesticidal activity and mechanism of piperazine derivatives have been studied extensively.  Herein, a comprehensive review of the research on the pesticidal bioactivity and mechanism of action of piperazine derivatives from 1971 to 2025 is presented.  The agriculturally relevant antifungal, insecticidal, anti-plant virus, herbicidal, acaricidal, and antibacterial activities are discussed and the molecular mechanism of action of related piperazine derivatives is summarized.  In addition, we also propose the future derivation direction of piperazine structures and look forward to the development of the anti-plant virus and anti-bacterial action mechanisms.

Keywords:  piperazine derivatives       pesticidal activities       structure–activity relationship mechanism of action       research progress  
Received: 24 February 2025   Accepted: 07 May 2025 Online: 02 June 2025  
Fund: 

We acknowledge the financial support from the National Key Research and Development Program of China (2022YFD1700300).

About author:  Yanju Wang, E-mail: 18985900557@163.com; #Correspondence Baoan Song, E-mail: basong@gzu.edu.cn

Cite this article: 

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