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Journal of Integrative Agriculture  2017, Vol. 16 Issue (12): 2772-2783    DOI: 10.1016/S2095-3119(17)61788-X
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Progress in the development and application of plant-based antiviral agents
LI Xiang-yang, SONG Bao-an
State Key Laboratory Breeding Base of Green Pesticide and Agricultural Bioengineering/Key Laboratory of Green Pesticide and Agricultural Bioengineering, Ministry of Education/Guizhou University, Guiyang 550025, P.R.China
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Abstract  Plant virus disease is one of the major causes of biological disasters in agriculture worldwide.  Given the complexity of transmission media and plant disease infection mechanisms, the prevention and control of plant viral diseases is a great challenge, and an efficient green pesticide is urgently needed.  For this reason, when developing candidate drug leads to regulate plant viruses, pesticide experts have focused on characteristics such as low pesticide resistance, eco-friendliness, and novel mechanism.  Researchers have also theoretically investigated the molecular targets of viruses infecting agricultural crops.  Antiviral screening models have been constructed based on these molecular targets, and the mechanisms of commercial drugs and high-activity compounds have been extensively investigated.  After screening, some compounds have been applied in the field and found to have good commercial prospects; these drugs may be used to create new green antiviral pesticides to control plant viruses.  This paper reviews the screening, mode of action, development and application of recently used plant-based antiviral agents.
Keywords:  research progress        antiviral agents        screening model        action mechanism       drug development and application  
Received: 04 July 2017   Accepted: 08 December 2017

This study was supported by the National Natural Science Foundation of China (21132003, 31460460, 21502032 and 21732002), the Subsidy Project for Outstanding Key Laboratory of Guizhou Province in China (20154004), the Provincial University Cooperation Plan of Guizhou Province in China (20147001) and the Collaborative Innovation Center for Natural Products and Biological Drugs of Yunnan, China.

Corresponding Authors:  Correspondence SONG Bao-an, Tel: +86-851-83620521, Fax: +86-851-83622211, E-mail:   

Cite this article: 

LI Xiang-yang, SONG Bao-an. 2017. Progress in the development and application of plant-based antiviral agents. Journal of Integrative Agriculture, 16(12): 2772-2783.

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