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Journal of Integrative Agriculture  2020, Vol. 19 Issue (6): 1439-1446    DOI: 10.1016/S2095-3119(19)62787-5
Special Focus: Physiology and interaction of insects with environmental factors Advanced Online Publication | Current Issue | Archive | Adv Search |
BmApontic is involved in neurodevelopment in the silkworm Bombyx mori
MENG Miao1*, YU Qi1, 2*, WANG Qin1, LIU Chun3, LIU Zhao-yang1, REN Chun-jiu1, CUI Wei-zheng1, LIU Qing-xin1  
1 Laboratory of Developmental Genetics, Shandong Agricultural University, Tai’an 271018, P.R.China
2 Shandong Agricultural University Library, Tai’an 271018, P.R.China
3 State Key Laboratory of Silkworm Genome Biology, Southwest University, Chongqing 400715, P.R.China
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The nervous system of the silkworm is vital for the development of organisms.  It achieves and maintains normal life activities by regulating the function of the organs and all kinds of physiological processes in the silkworm.  BmApontic (BmApt), as an important bZIP transcription factor, is required for the formation of pigmentation in the silkworm.  However, the function of BmApt in the development of the nervous system of the silkworm remains unclear.  Here, we showed that amino acid sequence of BmApt was evolutionarily conserved in its Myb/SANT motif and basic DNA binding domain.  BmApt was expressed in the nervous system at the embryonic stage.  Knockdown of Bmapt by RNA interference resulted in abnormal development of axons.  Moreover, the expression of BmnetrinA, BmnetrinB and Bmfrazzled was decreased in the Bmapt knockdown embryos.  These results demonstrate that BmApt controls neurodevelopment by activating the expression of Bmnetrin and Bmfrazzled
Keywords:  Bombyx mori        BmApontic        Bmnetrin        Bmfrazzled        neurodevelopment        RNA interference  
Received: 09 May 2019   Accepted: 26 April 2020
Fund: This work was supported by the National Natural Science Foundation of China (31571502, 31872971 and 31602011), the Funds of “Shandong Double Tops” Program, China (SYL2017YSTD09) and the earmarked fund for China Agriculture Research System (CARS-22).
Corresponding Authors:  Correspondence LIU Qing-xin, Tel: +86-538-8246398, E-mail:    
About author:  MENG Miao, E-mail:; YU Qi, E-mail:; * These authors contributed equally to this study.

Cite this article: 

MENG Miao, YU Qi, WANG Qin, LIU Chun, LIU Zhao-yang, REN Chun-jiu, CUI Wei-zheng, LIU Qing-xin. 2020. BmApontic is involved in neurodevelopment in the silkworm Bombyx mori. Journal of Integrative Agriculture, 19(6): 1439-1446.

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