畜禽粪便中兽用抗生素削减方法的研究进展

doi:10.3864/j.issn.0578-1752.2018.17.009

Abstract

Abstract: Veterinary antibiotics (VAs) have good effect on promoting growth and preventing animal disease. With the development of the intensive animal husbandry and formula feed industry, antibiotics were widely used around the world. The dependence on VAs is particularly serious in Chinese animal feeding operations. The annual VAs use amount exceeds 8 tons in China, which accounts for more than half of the total antibiotics. However, instead of being assimilated by animal guts, high percentage of antibiotics were excreted out as prototype or metabolites with urine and feces, and cause VAs residue in animal wastes to the highest concentration of 183.50 mg·kg-1. The residual VAs could enter the soil and water through various pathways, affect the activity of indigenous microorganism and cause the emergence and dissemination of antibiotic-resistant microorganism and antibiotic-resistant genes, posing potential risks to the ecosystem safety and human health. Thus, it is significant and emergent to efficiently remove residual VAs in animal waste. This paper introduced VAs contamination characteristics and occurrence regularity in animal wastes, reviewed the current research progress on the removal of veterinary antibiotics in livestock and poultry manure at home and abroad, introduced the classifications and process flows of the aerobic composting and anaerobic fermentation of livestock and poultry manure, summarized the removal efficiencies of VAs in animal wastes under aerobic composting and anaerobic fermentation and discussed the affecting factors of VAs removal efficiencies. Conclusion: the removal efficiencies of tetracycline, oxytetracycline, chlorotetracycline, sulfamethoxazole, sulfadiazine, sulfamerazine, ciprofloxacin, enrofloxacin and tylosin under aerobic composting could reach as high as 65.5%-100%, which was related to antibiotic types, concentration, adding ways, temperature, oxygen and substrate composition; anaerobic fermentation can completely remove Ampicillin, tetracycline and sulfamethoxydiazine, but has no effect on the remove of sulfadiazine, sulfamerazine, sulfamethoxazole, sulfamethoxin, trimethoprim and tylosin, related to antibiotic types, concentration, temperature, sludge, mixing rate and fermentation time. Finally, this paper suggested the aspects needing further research: strengthen the supervision and management of VAs, constitute relevant legislation and standards, accelerate the research of substitute to reduce source pollution; study the degradation products and mechanism; screen microorganisms with strong VAs biodegradability to enhance VAs reduction; study the relationship between antibiotics and ARGs to realize the simultaneous remove of veterinary antibiotics and ARGs.

Key words: veterinary antibiotics, livestock and poultry manure, aerobic composting, anaerobic fermentation

CHENG DengMiao, LI ZhaoJun, ZHANG XueLian, FENG Yao, ZHANG ShuQing. Removal of Veterinary Antibiotics in Livestock and Poultry Manure: A Review[J].Scientia Agricultura Sinica, 2018, 51(17): 3335-3352.

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