Abstract: Abstract: 【Objective】In this study, a doubled haploid (DH) population with 150 lines, which was derived from the cross of two Chinese common wheat cultivars Hanxuan 10 and Lumai 14, was used as the plant material to identify the adult-plant resistance to powdery mildew (APRPM) and carry out Quantitative trait loci (QTL) analysis. The purpose was to find some essential QTLs with stable and remarkable effects for marker-assisted selection for improving powdery mildew resistance in wheat breeding program.【Method】The mixed-model-based composite interval mapping method was employed to identify the quantitative trait loci (QTL) for APRPM in four single environments and across four environments.【Result】A total of 15 additive QTLs were detected in four single environments, explaining 3.8%～21.0% phenotype variance. Across four environments, 9 additive QTLs were detected. They were at the same flanking marker interval with the additive QTLs detected in four single environments, located on chromosome 2A, 2B, 3A, 5A, 5B, 6B, 7A, 7B and 7D, respectively. And 17 pairs of epistatic QTLs explaining 1.1%～28.4% phenotype variance were identified in four single environments. Across four environments, 19 pairs of epistatic QTLs were detected. Among them, 7 pairs QTLs shared the same flanking marker interval with QTLs identified in four single environments. The allelic contribution to the APRPM QTLs came from both parents. Some DH lines were more resistant to the adult-plant powdery mildew than their parents【Conclusion】Our results showed that the APRPM was controlled by both additive and epistatic QTLs. The overlapped QTLs were stable in different environments. Therefore, adult-plant resistance to powdery mildew can be improved in wheat breeding program by recombining and pyramiding target QTLs using marker assisted selection.