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Review and Prospect of Bivalent Recombinant Vaccine Against Infectious Laryngotracheitis and Fowlpox

WANG Yun-feng, TONG Guang-zhi   

  1. Division of Avian Infectious Diseases/National Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute of Chinese Academy of Agricultural Sciences, Harbin 150001
  • Online:2007-12-31 Published:2007-12-31

Abstract: Infectious laryngotracheitis (ILT) is an economically important acute viral upper respiratory tract infection of chickens. Present vaccines for ILT are all modified live viruses derived either by sequential passage in cell cultures or embryonated chicken eggs. As immunogenicity of ILTV usually correlates with its virulence, almost all modified live ILTV are insufficiently attenuated and have shown a variety of side effects. Therefore, vaccination has generally been used only in areas where the disease is endemic. A recombinant fowlpox virus expressed glycoprotein B of ILTV WG strain was constructed by TONG Guang Zhi et al in 1996. The recombinant vaccine is safer than attenuated vaccine for it does not cause latency infection. It can be applied not only in ILTV epidemic areas, but also in ILTV-free chicken farms. Serology methods can discriminate vaccinated chickens and highly virulent ILTV infected chickens. In 2006, the recombinant vaccine against both infectious laryngotracheitis and fowl pox was granted the second class National Prize for Scientific and Technological Progress. Here, it is reviewed that the history of the development of these vaccines, give a brief introduction of the investigators who led these research activities and their contributions to the projects, described the social demand and academic value.

Key words: Infectious laryngotracheitis , Recombinant fowlpox virus , Recombinant vaccine

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