正选择驱动褪黑激素受体MT1与MT2基因的分化

doi:10.3864/j.issn.0578-1752.2012.19.021

Abstract

Abstract: 【Objective】 This paper focused on molecular evolution of melatonin receptor (MTNR) genes for providing clues of gene biological function. 【Method】By using bioinformatics methods and softwares, the phylogenetic tree, genetic similarity, selection pressures and selection direction of melatonin receptor 1a (MT1) and melatonin receptor 1b (MT2) genes from 11 species were analyzed.【Result】MT1 and MT2 genes might come from a duplication of a common ancestor gene, MT1 might be keeping most functions of the parental gene and MT2 might be a new functional gene. The genetic similarity of MT1 genes among species was significantly higher than MT2 (P＜0.01). MT1 gene was undergone purifying selection while MT2 was under significant positive selection. Both of MT1 and MT2 were undergone strong selection pressure and there was no significant difference in selection pressure (P＞0.05) between the two genes.【Conclusion】Purifying selection for MT1 gene could explain the discrepancy of the association of MT1 gene with seasonal reproduction in animals and positive selection for MT2 gene showed that positive selection might be the main force driving the differentiation of MT2 and MT1.

Key words: melatonin receptor genes, genetic similarity, selection pressure, gene duplication, positive selection

HE Chun-Bo, JIANG Xun-Ping, LIU Gui-Qiong. Positive Selection Driven the Differentiation of Melatonin Receptor MT1 and MT2 Genes[J].Scientia Agricultura Sinica, 2012, 45(19): 4084-4091.

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Positive Selection Driven the Differentiation of Melatonin Receptor MT1 and MT2 Genes

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