Anderson D B, Kauffman R G. 1973. Cellular and enzymatic changes in porcine adipose tissue during growth. Journal of Lipid Research, 14, 160-168.

Backhed F, Ding H, Wang T, Hooper L V, Koh G Y, Nagy A, Semenkovich C F, Gordon J I. 2004. The gut microbiota as an environmental factor that regulates fat storage. Proceedings of the National Academy of Sciences of the United States of America, 101, 15718-15723.

Backhed F, Manchester J K, Semenkovich C F, Gordon J I. 2007. Mechanisms underlying the resistance to diet-induced obesity in germ-free mice. Proceedings of the National Academy of Sciences of the United States of America, 104, 979-984.

Belkaid Y, Harrison O J. 2017. Homeostatic Immunity and the Microbiota. Immunity, 46, 562-576.

Cai H Y, Zhang J H, Liu C, Le T N, Lu Y Y, Feng F Q, Zhao M J. 2024. High-Fat Diet-Induced Decreased Circulating Bile Acids Contribute to Obesity Associated with Gut Microbiota in Mice. Foods, 13, doi：103390/foods 13040512.

Cait A, Hughes M R, Antignano F, Cait J, Dimitriu P A, Maas K R, Reynolds L A, Hacker L, Mohr J, Finlay B B, Zaph C, McNagny K M, Mohn W W. 2018. Microbiome-driven allergic lung inflammation is ameliorated by short-chain fatty acids. Mucosal Immunology, 11, 785-795.

Cavallotti Gomez A, Rossi S P, Munduruca Pires T, Calandra R S, Da Ros V G, Cohen D J, Riano Gomez J M, Bianchi M S, Theas M S, Matzkin M E, Frungieri M B. 2025. Exploring the impact of metformin on testicular aging in Syrian hamsters. GeroScience. 47, 1033-1053.

Chen H, Cao G, Chen D Q, Wang M, Vaziri N D, Zhang Z H, Mao J R, Bai X, Zhao Y Y. 2016. Metabolomics insights into activated redox signaling and lipid metabolism dysfunction in chronic kidney disease progression. Redox Biology, 10, 168-178.

Chen J, Zhang X, He Z, Xiong D, Long M. 2024. Damage on intestinal barrier function and microbial detoxification of deoxynivalenol: A review. Journal of Integrative Agriculture, 23, 2507-2524.

Chen P, Cheng H, Chen S G, Ye X Q, Chen J L. 2026. Lacticaseibacillus rhamnosus alleviates hyperuricemia by restricting intestinal nucleoside absorption. Food & Function, 17, 216-230.

Chiang J Y L, Ferrell J M. 2020. Bile acid receptors FXR and TGR5 signaling in fatty liver diseases and therapy. American Journal of Physiology-Gastrointestinal and Liver Physiology, 318, G554-G573.

Church C D, Berry R, Rodeheffer M S. 2014. Isolation and study of adipocyte precursors. Methods in Enzymology, 537, 31-46.

Depommier C, Everard A, Druart C, Plovier H, Van Hul M, Vieira-Silva S, Falony G, Raes J, Maiter D, Delzenne N M, de Barsy M, Loumaye A, Hermans M P, Thissen J P, de Vos W M, Cani P D. 2019. Supplementation with Akkermansia muciniphila in overweight and obese human volunteers: a proof-of-concept exploratory study. Nature Medicine, 25, 1096–1103.

Devlin A S, Marcobal A, Dodd D, Nayfach S, Plummer N, Meyer T, Pollard K S, Sonnenburg J L, Fischbach M A. 2016. Modulation of a Circulating Uremic Solute via Rational Genetic Manipulation of the Gut Microbiota. Cell Host & Microbe, 20, 709-715.

Fleishman J S, Kumar S. 2024. Bile acid metabolism and signaling in health and disease: molecular mechanisms and therapeutic targets. Signal Transduction and Targeted Therapy, 9, doi: 10.1038/s41392-024-01845-6.

Gao K, Mu C L, Farzi A, Zhu W Y. 2020. Tryptophan Metabolism: A Link Between the Gut Microbiota and Brain. Advances in Nutrition, 11, 709-723.

Hauser N, Mourot J, De Clercq L, Genart C, Remacle C. 1997. The cellularity of developing adipose tissues in Pietrain and Meishan pigs. Reproduction Nutrition Development, 37, 617-625.

He P C, He C. 2021. m(6)A RNA methylation: from mechanisms to therapeutic potential. The EMBO Journal, 40, e105977.

He T, He L, Gao E, Hu J, Zang J, Wang C, Zhao J, Ma X. 2018. Fat deposition deficiency is critical for the high mortality of pre-weanling newborn piglets. Journal of Animal Science and Biotechnology, 9, 66.

Hu Y, Sang N, Wu A, Pu J, Yan H, Luo J, Zheng P, Luo Y, Yu J, He J, Yu B, Chen D. 2025. Different types of bile acids exhibit opposite regulatory effects on lipid metabolism in finishing pigs through bile acid receptors. Animal Nutrition, 21, 25-36.

Huang T, Song J, Gao J, Cheng J, Xie H, Zhang L, Wang Y H, Gao Z, Wang Y, Wang X, He J, Liu S, Yu Q, Zhang S, Xiong F, Zhou Q, Wang C Y. 2022. Adipocyte-derived kynurenine promotes obesity and insulin resistance by activating the AhR/STAT3/IL-6 signaling. Nature Communications, 13, 3489.

Jabs S, Biton A, Becavin C, Nahori M A, Ghozlane A, Pagliuso A, Spano G, Guerineau V, Touboul D, Giai Gianetto Q, Chaze T, Matondo M, Dillies M A, Cossart P. 2020. Impact of the gut microbiota on the m(6)A epitranscriptome of mouse cecum and liver. Nature Communications, 11, 1344.

Jia D J C, Wang Q W, Qi Y D, Jiang Y, He J M, Lin Y F, Sun Y, Xu J L, Chen W W, Fan L N, Yan R C, Zhang W, Ren G H, Xu C C, Ge Q W, Wang L, Liu W, Xu F, Wu P, Wang Y H, Chen S J, Wang L J. 2024. Microbial metabolite enhances immunotherapy efficacy by modulating T cell stemness in pan-cancer. Cell, 187,1651-1668.

Joe A W B, Yi L, Natarajan A, Le Grand F, So L, Wang J, Rudnicki M A, Rossi F M V. 2010. Muscle injury activates resident fibro/adipogenic progenitors that facilitate myogenesis. Nature Cell Biology, 12, 153-U44.

Krauss M, Schaller S, Borchers S, Findeisen R, Lippert J, Kuepfer L. 2012. Integrating cellular metabolism into a multiscale whole-body model. PLOS Computational Biology, 8, e1002750.

Krautkramer K A, Kreznar J H, Romano K A, Vivas E I, Barrett-Wilt G A, Rabaglia M E, Keller M P, Attie A D, Rey F E, Denu J M. 2016. Diet-Microbiota Interactions Mediate Global Epigenetic Programming in Multiple Host Tissues. Molecular Cell, 64, 982-992.

Kuang J L, Wang J Y, Li Y T, Li M C, Zhao M L, Ge K, Zheng D, Cheung K C P, Liao B Y, Wang S L, Chen T L, Zhang Y A, Wang C R, Ji G, Chen P, Zhou H W, Xie C, Zhao A H, Jia W P, Zheng X J, Jia W. 2023. Hyodeoxycholic acid alleviates non-alcoholic fatty liver disease through modulating the gut-liver axis. Cell Metabolism, 35, 1752-1768.

Li M, Wang S, Li Y, Zhao M, Kuang J, Liang D, Wang J, Wei M, Rajani C, Ma X, Tang Y, Ren Z, Chen T, Zhao A, Hu C, Shen C, Jia W, Liu P, Zheng X, Jia W. 2022. Gut microbiota-bile acid crosstalk contributes to the rebound weight gain after calorie restriction in mice. Nature Communications, 13, 2060.

Li M, Zhou H, Ding Y, Liu Z, Sun J, Li Z. 2020. Effects of Gut Microbiota on Bile Acid Profile and Bile Acid Metabolism in Piglets. Biotechnology Bulletin, 36, 49-61 (in Chinese).

Liu J, Tan Y Z, Cheng H, Zhang D D, Feng W W, Peng C. 2022. Functions of Gut Microbiota Metabolites, Current Status and Future Perspectives. Aging and Disease, 13, 1106-1126.

Liu S Q, Tu Y, Sun J B, Cai P R, Zhou Y B, Huang Y Q, Zhang S, Chen W T, Wang L Y, Du M, You W J, Wang T H, Wang Y Z, Lu Z Q, Shan T Z. 2023. Fermented mixed feed regulates intestinal microbial community and metabolism and alters pork flavor and umami. Meat Science, 201, doi: 10.1016/j.meatsci.2023.109198.

Liu Y, Xiao H, Wang Z T, Pan Q N, Zhao X, Lu B Y. 2025. Interactions between dietary cholesterol and intestinal flora and their effects on host health. Critical Reviews in Food Science and Nutrition, 65, 494-506.

Makishima M, Okamoto A Y, Repa J J, Tu H, Learned R M, Luk A, Hull M V, Lustig K D, Mangelsdorf D J, Shan B. 1999. Identification of a nuclear receptor for bile acids. Science, 284, 1362-1365.

Mao J D, Wei Y S, Ni Z X, Zhang J Z, Zhu J L, Wang H F. 2025. Gut microbiota-mediated bile acid transformations regulate the transport of aflatoxin B1 from the intestine to the liver in piglets. Journal of Animal Science and Biotechnology, 16, 38.

Natividad J M, Agus A, Planchais J, Lamas B, Jarry A C, Martin R, Michel M L, Chong-Nguyen C, Roussel R, Straube M, Jegou S, McQuitty C, Le Gall M, da Costa G, Lecornet E, Michaudel C, Modoux M, Glodt J, Bridonneau C, Sovran B, Dupraz L, Bado A, Richard M L, Langella P, Hansel B, Launay J M, Xavier R J, Duboc H, Sokol H. 2018. Impaired Aryl Hydrocarbon Receptor Ligand Production by the Gut Microbiota Is a Key Factor in Metabolic Syndrome. Cell Metabolism, 28, 737-749 e4.

Priya S, Burns M B, Ward T, Mars R A T, Adamowicz B, Lock E F, Kashyap P C, Knights D, Blekhman R. 2022. Identification of shared and disease-specific host gene-microbiome associations across human diseases using multi-omic integration. Nature Microbiology, 7, 780-795.

Qiu X Y, Liu Z H, Qin H L. 2021. Differences in Early Fat Development and Gene Transcription Expression in the Adipose Tissues of Piglets with and Without Gut Microbiota. Biotechnology Bulletin, 37, 56-66 (in Chinese).

Sasidharan Pillai S, Gagnon C A, Foster C, Ashraf A P. 2024. Exploring the Gut Microbiota: Key Insights Into Its Role in Obesity, Metabolic Syndrome, and Type 2 Diabetes. Journal of Clinical Endocrinology and Metabolism, 109, 2709-2719.

Sinha A K, Laursen M F, Brinck J E, Rybtke M L, Hjorne A P, Procházková N, Pedersen M, Roager H M, Licht T R. 2024. Dietary fibre directs microbial tryptophan metabolism via metabolic interactions in the gut microbiota. Nature Microbiology, 9, 196-207.

Song B, Azad M A, Zhu Q, Cheng Y T, Ding S J, Yao K, Kong X F. 2025. regulate muscle fiber type conversion in Chinese native pigs via tryptophan metabolism. npj Biofilms and Microbiomes, 11, 11.

Sun J Y, Fan J M, Li T T, Yan X X, Jiang Y H. 2022. Nuciferine Protects Against High-Fat Diet-Induced Hepatic Steatosis via Modulation of Gut Microbiota and Bile Acid Metabolism in Rats. Journal of Agricultural and Food Chemistry, 70, 12345-12358.

Thompson R S, Gaffney M, Hopkins S, Kelley T, Gonzalez A, Bowers S J, Vitaterna M H, Turek F W, Foxx C L, Lowry C A, Vargas F, Dorrestein P C, Wright K P Jr, Knight R, Fleshner M. 2021. Ruminiclostridium 5, Parabacteroides distasonis, and bile acid profile are modulated by prebiotic diet and associate with facilitated sleep/clock realignment after chronic disruption of rhythms. Brain, Behavior, and Immunity, 97, 150-166.

Turnbaugh P J, Ley R E, Mahowald M A, Magrini V, Mardis E R, Gordon J I. 2006. An obesity-associated gut microbiome with increased capacity for energy harvest. Nature, 444, 1027-1031.

Vaz F M, Ferdinandusse S. 2017. Bile acid analysis in human disorders of bile acid biosynthesis. Molecular Aspects of Medicine, 56, 10-24.

Wang Y H, Gao P W, Li C Y, Lu Y X, Zhang Y B, Zhou Y, Kong S Y. 2026. High-fidelity gut metagenome: A new insight of identification of functional probiotics. Journal of Integrative Agriculture, 25, 1330-1342.

Wang X Y, Li Y, Chen W J, Shi H L, Eren A M, Morozov A, He C, Luo G Z, Pan T. 2019. Transcriptome-wide reprogramming of N-methyladenosine modification by the mouse microbiome. Cell Research, 29, 167-170.

Yang F, Mao C Y, Guo L L, Lin J Y, Ming Q Q, Xiao P, Wu X, Shen Q Y, Guo S M, Shen D D, Lu R R, Zhang L Q, Huang S M, Ping Y Q, Zhang C L, Ma C, Zhang K, Liang X Y, Shen Y M, Nan F J, Yi F, Luca V C, Zhou J Y, Jiang C T, Sun J P, Xie X, Yu X, Zhang Y. 2020. Structural basis of GPBAR activation and bile acid recognition. Nature, 587, 499-504.

Yang M, Zheng X Q, Fan J J, Cheng W, Yan T M, Lai Y S, Zhang N P, Lu Y, Qi J L, Huo Z Y, Xu Z H, Huang J, Jiao Y T, Liu B D, Pang R, Zhong X, Huang S, Luo G Z, Lee G, Jobin C, Eren A M, Chang E B, Wei H, Pan T, Wang X Y. 2024. Antibiotic-Induced Gut Microbiota Dysbiosis Modulates Host Transcriptome and m(6)A Epitranscriptome via Bile Acid Metabolism. Advanced Science , 11, e2307981.

Zhang K, Xu Y, Zheng Y, Zhang T, Wu Y, Yan Y, Lei Y, Cao X, Wang X, Yan F, Lei Z, Brugger D, Chen Y, Deng L, Yang Y. 2024. Bifidobacterium pseudolongum-Derived Bile Acid from Dietary Carvacrol and Thymol Supplementation Attenuates Colitis via cGMP-PKG-mTORC1 Pathway. Advanced Science, 11, e2406917.

Zhang Y, Chen R, Zhang D D, Qi S, Liu Y. 2023. Metabolite interactions between host and microbiota during health and disease: Which feeds the other? Biomedicine & Pharmacotherapy, 160, 114295.

Zhernakova D V, Wang D M, Liu L, Andreu-Sánchez S, Zhang Y, Ruiz-Moreno A J, Peng H R, Plomp N, Del Castillo-Izquierdo A, Gacesa R, Lopera-Maya E A, Temba G S, Kullaya V I, van Leeuwen S S, Xavier R J, de Mast Q, Joosten L A B, Riksen N P, Rutten J H W, Netea M G, Sanna S, Wijmenga C, Weersma R K, Zhernakova A, Harmsen H J M, Fu J Y. 2024. Host genetic regulation of human gut microbial structural variation. Nature, 625, 813-821.

Zhong J, He X F, Gao X X, Liu Q H, Zhao Y, Hong Y, Zhu W Z, Yan J, Li Y F, Li Y, Zheng N N, Bao Y Y, Wang H, Ma J L, Huang W J, Liu Z K, Lyu Y Z, Ke X S, Jia W, Xie C, Hu Y Y, Sheng L L, Li H K. 2023. Hyodeoxycholic acid ameliorates nonalcoholic fatty liver disease by inhibiting RAN-mediated PPARalpha nucleus-cytoplasm shuttling. Nature Communications, 14, 5451.