Anwar M N, Guo S, Xin W, Hameed M, Wahaab A, Ma X C, Khan A U, Rahman S U,

Shao D H, Li Z J, Liu K, Li B B, Qiu Y F, Ma Z Y, Wei J C. 2021. Adaptation of a

live-attenuated genotype I Japanese encephalitis virus to vero cells is associated with mutations in structural protein genes. Virus Research, 292, 198256.

Anwar M N, Wang X, Hameed M, Wahaab A, Li C X, Sharma M, Pang L L, Malik M

I, Liu K, Li B B, Qiu Y F, Wei J C, Ma Z Y. 2020. Phenotypic and genotypic comparison of a live-attenuated genotype I Japanese encephalitis virus SD12-F120 strain with its virulent parental SD12 strain. Viruses-Basel, 12, 552.

Barzon L, Palu G. 2018. Recent developments in vaccines and biological therapies

against Japanese encephalitis virus. Expert Opinion on Biological Therapy, 18, 851-864.

Beasley D W C, Lewthwaite P, Solomon T. 2008. Current use and development of

vaccines for Japanese encephalitis. Expert Opinion on Biological Therapy, 8, 95-106.

Campbell G L, Hills S L, Fischer M, Jacobson J A, Hoke C H, Hombach J M, Marfin

A A, Solomon T, Tsai T F, Tsu V D, Ginsburg A S. 2011. Estimated global incidence of Japanese encephalitis: a systematic review. The Bulletin of the World Health Organization, 89, 766-774.

Cao L, Fu S H, Gao X Y, Li M H, Cui S H, Li X L, Cao Y X, Lei W W, Lu Z, He Y,

Wang H Y, Yan J H, Gao G F, Liang G D. 2016. Low protective efficacy of the current Japanese encephalitis vaccine against the emerging genotype 5 Japanese encephalitis virus. Plos Neglected Tropical Diseases, 10, e0004686.

Chambers T J, Nestorowicz A, Mason P W, Rice C M. 1999. Yellow fever/Japanese

encephalitis chimeric viruses: construction and biological properties. Journal of Virology, 73, 3095-3101.

Chiou S S, Chen J M, Chen Y Y, Chia M Y, Fan Y C. 2021. The feasibility of field

collected pig oronasal secretions as specimens for the virologic surveillance of Japanese encephalitis virus. Plos Neglected Tropical Diseases, 15, e0009977.

Cleton N B, Bosco-Lauth A, Page M J, Bowen R A. 2014. Age-related susceptibility

to Japanese encephalitis virus in domestic ducklings and chicks. American Journal of Tropical Medicine and Hygiene, 90, 242-246.

Di D, Li C X, Zhang J J, Hameed M, Wang X, Xia Q Q, Li H, Xi S M, Li Z J, Liu K,

Li B B, Shao D H, Qiu Y F, Wei J C, Ma Z Y. 2020. Experimental infection of newly hatched domestic ducklings via Japanese encephalitis virus infected mosquitoes. Pathogens, 9, 371.

Duong V, Choeung R, Gorman C, Laurent D, Crabol Y, Mey C, Peng B, Di Francesco

J, Hul V, Sothy H, Santy K, Richner B, Pommier J D, Sorn S, Chevalier V, Buchy P, de Lamballerie X, Cappelle J, Horwood P F, Dussart P. 2017. Isolation and full-genome sequences of Japanese encephalitis virus genotype I strains from Cambodian human patients, mosquitoes and pigs. Journal of General Virology, 98, 2287-2296.

Fan Y C, Chen J M, Chen Y Y, Lin J W, Chiou S S. 2013. Reduced neutralizing

antibody titer against genotype I virus in swine immunized with a live-attenuated genotype III Japanese encephalitis virus vaccine. Veterinary Microbiology, 163, 248-256.

Fan Y C, Chen J M, Chiu H C, Chen Y Y, Lin J W, Shih C C, Chen C M, Chang C C,

Chang G J J, Chiou S S. 2012. Partially neutralizing potency against emerging genotype I virus among children received for malin inactivated Japanese encephalitis virus Vaccine. Plos Neglected Tropical Diseases, 6, e1834

Fan Y C, Chen J M, Lin J W, Chen Y Y, Wu G H, Su K H, Chiou M T, Wu S R, Yin J

H, Liao J W, Chang G J J, Chiou S S. 2018. Genotype I of Japanese encephalitis virus virus-like particles elicit sterilizing immunity against genotype I and III viral challenge in swine. Scientific Reports, 8,7481 

Fan Y C, Liang J J, Chen J M, Lin J W, Chen Y Y, Su K H, Lin C C, Tu W C, Chiou

M T, Ou S C, Chang G J J, Lin Y L, Chiou S S. 2019. NS2B/NS3 mutations enhance the infectivity of genotype I Japanese encephalitis virus in amplifying hosts. PLoS Pathogens, 15, e1007992.

Geiss B J, Stahla H, Hannah A M, Gari H H, Keenan S M. 2009. Focus on

flaviviruses: current and future drug targets. Future Medicinal Chemistry, 1, 327-344.

Guirakhoo F, Zhang Z X, Chambers T J, Delagrave S, Arroyo J, Barrett A D T,

Monath T P. 1999. Immunogenicity, genetic stability, and protective efficacy of a recombinant, chimeric yellow fever Japanese encephalitis virus (ChimeriVax-JE) as  a live, attenuated vaccine candidate against Japanese encephalitis. Virology, 257, 363-372.

Guy B, Guirakhoo F, Barban V, Higgs S, Monath T P, Lang J. 2010. Preclinical and

clinical development of YFV 17D-based chimeric vaccines against dengue, West Nile and Japanese encephalitis viruses. Vaccine, 28, 632-649.

Halstead S B, Thomas S J. 2011. New Japanese encephalitis vaccines: alternatives to

production in mouse brain. Expert Review of Vaccines, 10, 355-364.

Hameed M, Liu K, Anwar M N, Wahaab A, Safdar A, Di D, Boruah P, Xu J P, Wang

X, Li B B, Zhu H M, Nawaz M, Shao D H, Qiu Y F, Wei J C, Ma Z Y. 2019. The emerged genotype I of Japanese encephalitis virus shows an infectivity similar to genotype III in mosquitoes from China. Plos Neglected Tropical Diseases, 13, e0007716.

Konishi E, Ajiro N, Nukuzuma C, Mason P W, Kurane I. 2003. Comparison of

protective efficacies of plasmid DNAs encoding Japanese encephalitis virus proteins that induce neutralizing antibody or cytotoxic T lymphocytes in mice. Vaccine, 21, 3675-3683.

Lindsey N P, Staples J E, Jones J F, Sejvar J J, Griggs A, Iskander J, Miller E R,

Fischer M. 2010. Adverse event reports following Japanese encephalitis vaccination in the United States, 1999-2009. Vaccine, 29, 58-64.

Liu W J, Fu S H, Ma X M, Chen X J, Wu D, Zhou L W, Yin Q K, Li F, He Y, Lei W

W, Li Y X, Xu S T, Wang H Q, Wang Z H, Wang H Y, Yu H, Liang G D. 2020. An outbreak of Japanese encephalitis caused by genotype Ib Japanese encephalitis virus in China, 2018: a laboratory and field investigation. Plos Neglected Tropical Diseases, 14, e0008312.

Luca V C, AbiMansour J, Nelson C A, Fremont D H. 2012. Crystal structure of the

Japanese encephalitis virus envelope protein. Journal of Virology, 86, 2337-2346.

McLean R K, Graham S P. 2022. The pig as an amplifying host for new and emerging zoonotic viruses. One Health, 14, 100384.

Monath T P, Soike K, Levenbook I, Zhang Z X, Arroyo J, Delagrave S, Myers G,

Barrett A D T, Shope R E, Ratterree M, Chambers T J, Guirakhoo F. 1999. Recombinant, chimaeric live, attenuated vaccine (ChimeriVax™) incorporating the envelope genes of Japanese encephalitis (SA14-14-2) virus and the capsid and nonstructural genes of yellow fever (17D) virus is safe, immunogenic and protective in nonhuman primates. Vaccine, 17, 1869-1882.

Muller D A, Young P R. 2013. The flavivirus NS1 protein: Molecular and structural

biology, immunology, role in pathogenesis and application as a diagnostic biomarker. Antiviral Research, 98, 192-208.

Ooi M H, Lewthwaite P, Lai B F, Mohan A, Clear D, Lim L, Krishnan S, Preston T,

Chieng C H, Tio P H, Wong S C, Cardosa J, Solomon T. 2008. The epidemiology, clinical features, and long-term prognosis of Japanese encephalitis in central sarawak, malaysia, 1997-2005. Clinical Infectious Diseases, 47, 458-468.

Pan X L, Liu H, Wang H Y, Fu S H, Liu H Z, Zhang H L, Li M H, Gao X Y, Wang J

L, Sun X H, Lu X J, Zhai Y G, Meng W S, He Y, Wang H Q, Han N, Wei B, Wu Y G, Feng Y, Yang D J, Wang L H, Tang Q, Xia G L, Kurane I, Rayner S, Liang G D. 2011. Emergence of Genotype I of Japanese Encephalitis Virus as the Dominant Genotype in Asia. Journal of Virology, 85, 9847-9853.

Pearce J C, Learoyd T P, Langendorf B J, Logan J G. 2018. Japanese encephalitis: the

vectors, ecology and potential for expansion. The Journal of Travel Medicine, 25, S16-S26.

Pierson T C, Diamond M S. 2020. The continued threat of emerging flaviviruses.

Nature Microbiology, 5, 796-812.

Plesner A M, Ronne T, Wachmann H. 2000. Case-control study of allergic reactions to

Japanese encephalitis vaccine. Vaccine, 18, 1830-1836.

Ricklin M E, Garcia-Nicolas O, Brechbuhl D, Python S, Zumkehr B, Nougairede A,

Charrel R N, Posthaus H, Oevermann A, Summerfield A. 2016. Vector-free transmission and persistence of Japanese encephalitis virus in pigs. Nature Communications, 7, 10832.

Sampath A, Padmanabhan R. 2009. Molecular targets for flavivirus drug discovery.

Antiviral Research, 81, 6-15.

Sun Y, Ding H, Zhao F, Yan Q, Li Y, Niu X, Zeng W, Wu K, Ling B, Fan S, Zhao M,

Yi L, Chen J. 2022. Genomic characteristics and E protein bioinformatics analysis of JEV isolates from south China from 2011 to 2018. Vaccines (Basel), 10, 1303.

Tang Q W, Deng Z F, Tan S G, Song G, Zhang H, Ge L R. 2022. Prevalence and

Genetic Characteristics of Japanese Encephalitis Virus among Mosquitoes and Pigs in Hunan Province, China from 2019 to 2021. Journal of Microbiology and Biotechnology, 32, 1120-1125.

Teng M, Luo J, Fan J M, Chen L, Wang X T, Yao W, Wang C Q, Zhang G P. 2013.

Molecular characterization of Japanese encephalitis viruses circulating in pigs and mosquitoes on pig farms in the Chinese province of Henan. Virus Genes, 46, 170-174.

Tiroumourougane S V, Raghava P, Srinivasan S. 2002. Japanese viral encephalitis.

Postgraduate Medical Journal, 78, 205-215.

Unni S K, Ruzek D, Chhatbar C, Mishra R, Johri M K, Singh S K. 2011. Japanese

encephalitis virus: from genome to infectome. Microbes and Infection, 13, 312-321.

Van den Hurk A F, Ritchie S A, Mackenzie J S. 2009. Ecology and Geographical

Expansion of Japanese Encephalitis Virus. Annual Review of Entomology, 54, 17-35.

Waggoner J J, Gresh L, Vargas M J, Ballesteros G, Tellez Y, Soda K J, Sahoo M K,

Nunez A, Balmaseda A, Harris E, Pinsky B A. 2016. Viremia and Clinical Presentation in Nicaraguan Patients Infected With Zika Virus, Chikungunya Virus, and Dengue Virus. Clinical Infectious Diseases, 63, 1584-1590.

Wei J, Hameed M, Wang X, Zhang J, Guo S, Anwar M N, Pang L, Liu K, Li B, Shao

D, Qiu Y, Zhong D, Zhou B, Ma Z. 2020. Antiviral activity of phage display-selected peptides against Japanese encephalitis virus infection in vitro and in vivo. Antiviral Research, 174, 104673.

Wei J C, Wang X, Zhang J J, Guo S, Pang L L, Shi K, Liu K, Shao D H, Qiu Y F, Liu

L H, Widén F, Li B B, Ma Z Y. 2019. Partial cross-protection between Japanese encephalitis virus genotype I and III in mice. Plos Neglected Tropical Diseases, 13, e0007601.

Wilder-Smith A, Halstead S B. 2010. Japanese encephalitis: update on vaccines and

vaccine recommendations. Current Opinion in Infectious Diseases, 23, 426-431.

Xia Q Q, Zhang Y, Yang Y, Ma X C, Guan Z X, Zhang J J, Li Z J, Liu K, Li B B,

Shao D H, Qiu Y F, Wei J C, Ma Z Y. 2022. Virulence and cross protection conferred by an attenuated genotype I based chimeric Japanese encephalitis virus strain harboring the E protein of genotype V in mice. Microbiology Spectrum, 10, e0199022.

Xiao C G, Li C X, Di D, Cappelle J, Liu L H, Wang X, Pang L L, Xu J P, Liu K, Li B

B, Shao D H, Qiu Y F, Ren W J, Widen F, Chevalier V, Wei J C, Wu X D, Ma Z Y. 2018. Differential replication efficiencies between Japanese encephalitis virus genotype I and III in avian cultured cells and young domestic ducklings. Plos Neglected Tropical Diseases, 12, e0007046.

Yang Y, Liang N X, Tan Y, Xie Z C. 2016. Epidemiological trends and characteristics

of Japanese encephalitis changed based on the vaccination program between 1960 and 2013 in Guangxi Zhuang Autonomous Region, southern China. International Journal of Infectious Diseases, 45, 135-138.

Yu Y X. 2010. Phenotypic and genotypic characteristics of Japanese encephalitis

attenuated live vaccine virus SA14-14-2 and their stabilities. Vaccine, 28, 3635-3641.

Yun S I, Lee Y M. 2014. Japanese encephalitis The virus and vaccines. Human

Vaccines & Immunotherapeutics, 10, 263-279.

Zhang Y, Li Y H, Guan Z X, Yang Y, Zhang J J, Sun Q, Li B B, Qiu Y F, Liu K, Shao

D H, Ma Z Y, Wei J C, Li P. 2022. Rapid differential detection of Japanese encephalitis virus and getah virus in pigs or mosquitos by a duplex TaqMan real-time RT-PCR assay. Frontiers in Veterinary Science, 9, 839443.

Zhang Y P, Jing J, Li X F, Wang J M, Feng X L, Cao R B, Chen P Y. 2015. Integration

analysis of miRNA and mRNA expression profiles in swine testis cells infected with Japanese encephalitis virus. Infection Genetics and Evolution, 32, 342-347.

Zheng B H, Wang X G, Liu Y X, Li Y C, Long S W, Gu C Q, Ye J, Xie S S, Cao S B.

2019. Japanese encephalitis virus infection induces inflammation of swine testis through RIG-I-NF-κB signaling pathway. Veterinary Microbiology, 238, 108430.

Zheng Y Y, Li M H, Wang H Y, Liang G D. 2012. Japanese encephalitis and Japanese

encephalitis virus in mainland China. Reviews in Medical Virology, 22, 301-322.