Scientia Agricultura Sinica ›› 2012, Vol. 45 ›› Issue (15): 3130-3136.doi: 10.3864/j.issn.0578-1752.2012.15.015

• ANIMAL SCIENCE·RESOURCE INSECT • Previous Articles     Next Articles

Effect of Intrauterine Growth Restriction During Late Pregnancy on Visceral Organs of Postnatal Lambs

 GAO  Feng, LIU  Ying-Chun   

  1. 1.内蒙古农业大学动物科学学院，呼和浩特 010018
    2.内蒙古农业大学生命科学学院，呼和浩特010018
  • Online:2012-08-01 Published:2012-08-01

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Abstract: 【Objective】 The effects of intrauterine growth restriction during late pregnancy on the visceral organs of postnatal lambs were studied. 【Method】 Forty-five Mongolia ewes, mated at a synchronized oestrus, were divided into three groups and offered three diets during late pregnancy (90±1) days. The dietary treatments were ad libitum access to feed (control group, CG), 0.33 MJ ME•kgw-0.75•d-1 (restricted group1, RG1), and 0.175 MJ ME•kgw-0.75•d-1 (restricted group 2, RG2), respectively. Four lambs in each group were selected and slaughtered immediately after parturition (neonatal lambs) and at 28-wk of age, and the major visceral organs were removed and weighed separately.【Result】 The results indicated that the maternal undernutrition reduced the average birth weight in RG1 (P＜0.05) and RG2 (P＜0.01) compared to CG. For neonatal lambs, the weights and the DNA content both in the lung (P＜0.05) and spleen (P＜0.01) in RG1 were significantly decreased compared with CG. In RG2, the weights of the lung and spleen were lower (P＜0.01), and the weights of heart, liver, kidney, stomach, small intestine were lower than those in CG (P＜0.05). The DNA content in kidney and heart, the ratio between the DNA content and protein in lung and liver were decreased compared with CG (P＜0.05). At 28 wk of age, the weights of lung and spleen and their DNA contents in RG1 had no significant difference compared with CG (P＞0.05). In RG2, except for heart, there were no significant difference in weights of lung, spleen and liver compared with CG (P＞0.05), and the difference of the DNA content in kidney and spleen, the protein/DNA ratio in liver were not observed (P＞0.05), and the protein/DNA ratio in lung increased compared with CG (P＜0.05). The DNA content in heart and lung, however, was greatly lower (P＜0.05) than those of CG. 【Conclusion】 It was concluded that intrauterine growth restriction during the late pregnancy had an adverse effect on weight and cellularity of postnatal visceral organs, and these perturbations of hyperplasia or hypertrophy in fetal visceral organs development may have a significant potential effect on postnatal growth and adult health.

Key words: late pregnancy, intrauterine growth restriction, postnatal lambs, visceral Organs

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