Abstract:

【Objective】 The objective of the study is to develop a physiologically based pharmacokinetic model for ciprofloxacin in rats to predict drug concentration changed with time more accurately. 【Method】 Through collecting the physico chemical properties and pharmacokinetic characteristics of ciprofloxacin, and the physiological and physiochemical parameters of rats, a model was hypothesized according to physiology and anatomy and mass-energy conservation laws. 【Result】 Rheogram of physiologically based pharmacokinetic model of ciprofloxacin in rats was designed successfully. 【Conclusion】 The successful design of rheogram has laid a good foundation for establishment of the physiologically based pharmacokinetic model of ciprofloxacin in rats.

Key words: ciprofloxacin, physiologically based pharmacokinetic model, rheogram